Oral methotrexate is as effective as intramuscular in maintenance therapy of acute lymphoblastic leukaemia. by Chessells, J, Leiper, A, Tiedemann, K, Hardisty, R, Richards, S

“…One hundred and forty four children with acute lymphoblastic leukaemia not of the T cell type were randomised to receive continuing treatment with daily 6-mercaptopurine, vincristine, and prednisolone six weekly and methotrexate once weekly, either as a single oral dose or an intramuscular injection. …”

Medical Research Council leukaemia trial--UKALL V: an attempt to reduce the immunosuppressive effects of therapy in childhood acute lymphoblastic leukemia. Report to the Council by... by Chessells, J, Durrant, J, Hardy, R, Richards, S

“…All 496 children were randomized to receive chemotherapy for 2 or 3 years with 6-mercaptopurine and methotrexate either as a continuous (group C) or a semicontinuous (group G) regimen or as a five-day pulse every 3 weeks (group I). …”