Study protocol: E-freeze - freezing of embryos in assisted conception: a randomised controlled trial evaluating the clinical and cost effectiveness of a policy of freezing embryos followed by thawed frozen embryo transfer compared with a policy of fresh embryo transfer, in women undergoing in vitro fertilisation by Maheshwari, A, Bhattacharya, S, Bowler, U, Brison, D, Child, T, Cole, C, Coomarasamy, A, Cutting, R, Harbottle, S, Hardy, P, Juszczak, E, Khalaf, Y, Kurinczuk, J, Lavery, S, Lewis-Jones, C, Macklon, N, Raine-Fenning, N, Rajkohwa, M, Scotland, G, Troup, S

“…BACKGROUND:Infertility affects one in seven couples; many of these need in vitro fertilisation (IVF). IVF involves external hormones to stimulate a woman's ovaries to produce eggs which are harvested surgically. …”

Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF: the E-Freeze RCT by Maheshwari, A, Bari, V, Bell, JL, Bhattacharya, S, Bhide, P, Bowler, U, Brison, D, Child, T, Chong, HY, Cheong, Y, Cole, C, Coomarasamy, A, Cutting, R, Goodgame, F, Hardy, P, Hamoda, H, Juszczak, E, Khalaf, Y, King, A, Kurinczuk, JJ, Lavery, S, Lewis-Jones, C, Linsell, L, Macklon, N, Mathur, R, Murray, D, Pundir, J, Raine-Fenning, N, Rajkohwa, M, Robinson, L, Scotland, G, Stanbury, K, Troup, S

“…<br><strong> Setting<br></strong> Eighteen in vitro fertilisation clinics across the UK participated from February 2016 to April 2019. …”

Does advancing male age influence the expression levels and localisation patterns of phospholipase C zeta (PLCζ) in human sperm? by Yeste, M, Jones, C, Amdani, S, Yelumalai, S, Mounce, G, Martins da Silva, S, Child, T, Coward, K

“…One fundamental role of sperm is to activate the oocyte at fertilisation, a process initiated by phospholipase C zeta (PLCζ), a sperm-specific protein. …”

Detection of soluble ST2 in human follicular fluid and luteinized granulosa cells by Southcombe, J, Lédée, N, Perrier D'Hauterive, S, Turner, K, Child, T, Snider, J, Redman, C, Sargent, I, Granne, I

“…FF associated with oocytes which when fertilised develop into good quality embryos have higher sST2 levels than those which are graded average (p&lt;0.01). …”

Human chorionic gonadotrophin priming for fertility treatment with in vitro maturation. by Reavey, J, Vincent, K, Child, T, Granne, I

“… <h4>Background</h4> <p>In vitro maturation (IVM) is a fertility treatment that involves the transvaginal retrieval of immature oocytes, and their subsequent maturation and fertilisation. Although the live birth rate is lower than conventional in vitro fertilisation (IVF) with ovarian stimulation, it is a useful treatment, as it avoids the risk of ovarian hyperstimulation syndrome (OHSS). …”

In vitro decidualisation of human endometrial stromal cells is enhanced by seminal fluid extracellular vesicles by Rodriguez-Caro, H, Dragovic, R, Shen, M, Dombi, E, Mounce, G, Field, K, Meadows, J, Turner, K, Lunn, D, Child, T, Southcombe, J, Granne, I

“…Abbreviations: ECACC: European Collection of Authenticated Cell Cultures; ESCs: endometrial stromal cells; EVs: extracellular vesicles; FCS: foetal calf serum; HRP: horse-radish peroxidase; IFNγ: interferon-gamma; IGF: insulin-like growth factor; IGFBP-1: insulin-like growth factor binding protein 1; IVF: in vitro fertilisation; MVB: multivesicular bodies; NTA: nanoparticle tracking analysis; PRLR−/−: homozygous prolactin receptor knockout; RT: room temperature; SF-EVs: seminal fluid extracellular vesicles; STR: short tandem repeat; TGFβ: transforming growth factor β; uNK: uterine natural killer…”