A functional analysis of mouse models of cardiac disease through metabolic profiling. by Jones, G, Sang, E, Goddard, C, Mortishire-Smith, R, Sweatman, B, Haselden, J, Davies, K, Grace, A, Clarke, K, Griffin, J

“…Metabolic profiling of cardiac tissue through high resolution NMR spectroscopy in conjunction with multivariate statistics has been used to classify mouse models of cardiac disease. The data sets included metabolic profiles from mouse models of Duchenne muscular dystrophy, two models of cardiac arrhythmia, and one of cardiac hypertrophy. …”

Myocardial substrate metabolism in heart disease. by Evans, R, Clarke, K

“…Cardiac disease is commonly associated with changes in energy substrate metabolism. …”

Normal values of regional and global myocardial wall motion in young and elderly individuals using navigator gated tissue phase mapping. by Codreanu, I, Pegg, T, Selvanayagam, J, Robson, M, Rider, O, Dasanu, C, Jung, B, Taggart, D, Golding, S, Clarke, K, Holloway, C

“…These parameters may have a role in the assessment of global LV contractility and help differentiate age-related changes from cardiac disease.…”

Normal values of regional and global myocardial wall motion in young and elderly individuals using navigator gated tissue phase mapping by Codreanu, I, Pegg, T, Selvanayagam, J, Robson, M, Rider, O, Dasanu, C, Jung, B, Taggart, D, Golding, S, Clarke, K, Holloway, C

“…These parameters may have a role in the assessment of global LV contractility and help differentiate age-related changes from cardiac disease. © American Aging Association 2013.…”

First-pass perfusion CMR two days after infarction predicts severity of functional impairment six weeks later in the rat heart. by Stuckey, D, Carr, C, Meader, S, Tyler, D, Cole, M, Clarke, K

“…Despite the clinical importance of this method, it has rarely been applied in small animal models of cardiac disease. In order to identify perfusion delays in the infarcted rat heart, here we present a method in which a T1 weighted MR image has been acquired during each cardiac cycle. …”

Investigating mitochondrial metabolism in contracting HL-1 cardiomyocytes following hypoxia and pharmacological HIF activation identifies HIF-dependent and independent mechanisms o... by Ambrose, L, Abd-Jamil, A, Gomes, R, Carter, E, Carr, C, Clarke, K, Heather, L

“…Hypoxia is a consequence of cardiac disease and downregulates mitochondrial metabolism, yet the molecular mechanisms through which this occurs in the heart are incompletely characterized. …”

Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS. by Atherton, H, Schroeder, M, Dodd, M, Heather, L, Carter, E, Cochlin, L, Nagel, S, Sibson, N, Radda, G, Clarke, K, Tyler, D

“…Consequently, there is much interest in the in vivo evaluation of PDH activity in a range of physiological and pathological states to obtain information on the metabolic mechanisms of cardiac diseases. Hyperpolarised [1-(13)C]pyruvate, detected using MRS, is a novel technique for the noninvasive evaluation of PDH flux. …”