Homocysteine and cardiovascular disease. Overview. by Clarke, R

Vitamin D and Risk of Cardiovascular and Non-Cardiovascular Mortality: A Prospective Cohort Study and Meta-Analysis by Emberson, JR, Tomson, J, Hill, M, Armitage, J, Leon, D, Fletcher, A, Collins, R, Clarke, R

Homocysteine, renal function, and risk of cardiovascular disease. by Clarke, R, Lewington, S, Landray, M

“…RESULTS: Among prospective studies, a 25% lower blood homocysteine level was associated with an 11% lower risk of IHD and about a 20% lower risk of stroke, after adjustment for known cardiovascular risk factors. Individuals who had the TT genotype for MTHFR compared with those with CC had 25% higher homocysteine levels and a 16% higher risk of IHD. …”

Homocysteine, B-vitamins, and the risk of cardiovascular disease. by Clarke, R, Smulders, Y, Fowler, B, Stehouwer, C

Homocysteine and risk of cardiovascular disease and venous thrombosis by Clarke, R, den Heijer, M, Sherliker, P, Lewington, S

Homocysteine, B vitamins, and the risk of cardiovascular disease. by Clarke, R

The burden of hypertension and associated risk for cardiovascular mortality in China. by Lewington, S, Lacey, B, Clarke, R, Guo, Y, Kong, X, Yang, L, Chen, Y, Bian, Z, Chen, J, Meng, J, Xiong, Y, He, T, Pang, Z, Zhang, S, Collins, R, Peto, R, Li, L, Chen, Z

“…Hypertension is a leading cause of premature death in China, but limited evidence is available on the prevalence and management of hypertension and its effect on mortality from cardiovascular disease (CVD).To examine the prevalence, diagnosis, treatment, and control of hypertension and to assess the CVD mortality attributable to hypertension in China.This prospective cohort study (China Kadoorie Biobank Study) recruited 500 223 adults, aged 35 to 74 years, from the general population in China. …”

Risk of frailty and cardiovascular disease in the China Kadoorie Biobank by Kim, D

“…<p><strong>Background:</strong> Frailty and cardiovascular disease (CVD) are an increasing burden in rapidly ageing societies like China. …”

C-reactive protein, fibrinogen, and cardiovascular disease prediction. by Kaptoge, S, Di Angelantonio, E, Pennells, L, Wood, A, White, I, Gao, P, Walker, M, Thompson, A, Sarwar, N, Caslake, M, Butterworth, A, Amouyel, P, Assmann, G, Bakker, S, Barr, E, Barrett-Connor, E, Benjamin, E, Björkelund, C, Brenner, H, Brunner, E, Clarke, R, Cooper, J, Cremer, P, Cushman, M, Dagenais, G

“…BACKGROUND: There is debate about the value of assessing levels of C-reactive protein (CRP) and other biomarkers of inflammation for the prediction of first cardiovascular events. METHODS: We analyzed data from 52 prospective studies that included 246,669 participants without a history of cardiovascular disease to investigate the value of adding CRP or fibrinogen levels to conventional risk factors for the prediction of cardiovascular risk. …”

Long-term weight loss and prevention of cardiovascular disease. by Clarke, R

Homocysteine-lowering And Cardiovascular Disease: Is The Door Closing Now by Clarke, R

Uncontrolled hypertension and risk of cardiovascular mortality in China-reply by Lewington, S, Lacey, B, Clarke, R

Assessment of homocysteine as a cardiovascular risk factor in clinical practice. by Clarke, R, Stansbie, D

“…Elevated plasma total homocysteine concentrations are a marker of vitamin deficiency and a risk factor for cardiovascular disease. It is possible that vitamin supplementation with folic acid and other B vitamins, which lower plasma homocysteine concentrations, may reduce the risk of cardiovascular disease. …”

Commentary: an updated review of the published studies of homocysteine and cardiovascular disease. by Clarke, R

Cardiovascular risk factors and Parkinson’s disease in 500,000 Chinese adults by Clarke, R, Lewington, S, Mappin‐Kasirer, B, Turnbull, I, Guo, Y, Bian, Z, Chen, Y, Yang, L, Chen, Z, Clarke, R, China Kadoorie Biobank

“…Cox proportional hazards models were used to assess associations of history of heart disease or stroke with Parkinson's disease in all participants, and of cardiovascular disease risk factors with Parkinson's disease in a subset without prior cardiovascular disease. …”

Combined effects of systolic blood pressure and total cholesterol on cardiovascular disease risk. by Lewington, S, Clarke, R

WHO cardiovascular disease risk prediction model performance in 10 regions, China by Yang, S, Ding, Y, Yu, C, Guo, Y, Pang, Y, Sun, D, Pei, P, Yang, L, Chen, Y, Du, H, Schmidt, D, Stevens, R, Bennett, D, Clarke, R, Chen, J, Chen, Z, Li, L, Lv, J

“…<p><strong>Objective</strong></p> <p>To validate the World Health Organization (WHO) non-laboratory-based cardiovascular disease risk prediction model in regions of China.…”

Risk prediction for cardiovascular disease using ECG data in the China Kadoorie Biobank by Shen, Y, Yang, Y, Parish, S, Chen, Z, Clarke, R, Clifton, D

“…We set out to use machine learning techniques to analyse ECG data to improve risk evaluation of cardiovascular disease in a very large cohort study of the Chinese population. …”

Antioxidant vitamins and risk of cardiovascular disease. Review of large-scale randomised trials. by Clarke, R, Armitage, J

“…People who consume a diet rich in fruit and vegetables have lower risks of cancer, cardiovascular disease and all-cause mortality. Many prospective cohort studies have reported inverse associations between dietary intake or blood levels of beta-carotene and risks of cancer. …”

Combined effects of systolic blood pressure and total cholesterol on cardiovascular disease risk by Lewington, S, Clarke, R