The Interaction between hERG1 and β1 Integrins Modulates hERG1 Current in Different Pathological Cell Models by Ginevra Chioccioli Altadonna, Alberto Montalbano, Jessica Iorio, Andrea Becchetti, Annarosa Arcangeli, Claudia Duranti

Subjects: “…hERG1…”
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Prognostic role of hERG1 Potassium Channels in Neuroendocrine Tumours of the Ileum and Pancreas by Jessica Iorio, Lorenzo Antonuzzo, Emanuela Scarpi, Massimo D’Amico, Claudia Duranti, Luca Messerini, Clotilde Sparano, Damiano Caputo, Daniele Lavacchi, Domenico Borzomati, Alice Antonelli, Lorenzo Nibid, Giuseppe Perrone, Alessandro Coppola, Roberto Coppola, Francesco di Costanzo, Elena Lastraioli, Annarosa Arcangeli

Subjects: “…hERG1 channel…”
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Combination Therapy with a Bispecific Antibody Targeting the hERG1/β1 Integrin Complex and Gemcitabine in Pancreatic Ductal Adenocarcinoma by Tiziano Lottini, Claudia Duranti, Jessica Iorio, Michele Martinelli, Rossella Colasurdo, Franco Nicolás D’Alessandro, Matteo Buonamici, Stefano Coppola, Valentina Devescovi, Vincenzo La Vaccara, Alessandro Coppola, Roberto Coppola, Elena Lastraioli, Annarosa Arcangeli

“…With the aim of improving the treatment outcome of PDAC, we tested the effect of combining Gemcitabine with a novel single chain bispecific antibody (scDb) targeting the cancer-specific hERG1/β1 integrin complex. First, using the scDb (scDb-hERG1-β1) in immunohistochemistry (IHC), Western blot (WB) analysis and immunofluorescence (IF), we confirmed the presence of the hERG1/β1 integrin complex in primary PDAC samples and PDAC cell lines. …”
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Cardiac safety assessment of a novel recombinant bispecific antibody targeting the ether-à-go-go related gene 1 (hERG1)-β1 integrin macromolecular complex by Lorenzo Santini, Claudia Duranti, Chiara Palandri, Lucrezia Giammarino, Monica Musumeci, Lucia Carlucci, Chiara Capitani, Chiara Capitani, Rossella Colasurdo, Rossella Colasurdo, Fabio Recchia, Elisabetta Cerbai, Raffaele Coppini, Annarosa Arcangeli

“…Cardiac cells were incubated in vitro with i) the scDb-hERG1-β1, ii) the full length anti-hERG1 monoclonal antibody (mAb-hERG1) and iii) its single chain Fragment variable derivative (scFv-hERG1), from which the scDb-hERG1-β1 was assembled. …”
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Ion Channel Targeting with Antibodies and Antibody Fragments for Cancer Diagnosis by Claudia Duranti, Annarosa Arcangeli

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The Activity of Kv 11.1 Potassium Channel Modulates F-Actin Organization During Cell Migration of Pancreatic Ductal Adenocarcinoma Cells by Sagar Manoli, Stefano Coppola, Claudia Duranti, Matteo Lulli, Lara Magni, Nirmala Kuppalu, Nikolaj Nielsen, Thomas Schmidt, Albrecht Schwab, Andrea Becchetti, Annarosa Arcangeli

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