Inflammation marker and risk of pancreatic cancer: a nested case-control study within the EPIC cohort. by Grote, V, Kaaks, R, Nieters, A, Tjønneland, A, Halkjær, J, Overvad, K, Skjelbo Nielsen, MR, Boutron-Ruault, M, Clavel-Chapelon, F, Racine, A, Teucher, B, Becker, S, Pischon, T, Boeing, H, Trichopoulou, A, Cassapa, C, Stratigakou, V, Palli, D, Krogh, V, Tumino, R, Vineis, P, Panico, S, Rodríguez, L, Duell, E, Sánchez, M

“…METHODS: We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, measuring prediagnostic blood levels of C-reactive protein (CRP), interleukin-6 (IL-6), and soluble receptors of tumour necrosis factor-α (sTNF-R1, R2) in 455 pancreatic cancer cases and 455 matched controls. …”

Prediagnostic circulating vitamin D levels and risk of hepatocellular carcinoma in European populations: a nested case-control study. by Fedirko, V, Duarte-Salles, T, Bamia, C, Trichopoulou, A, Aleksandrova, K, Trichopoulos, D, Trepo, E, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, M, Clavel-Chapelon, F, Kvaskoff, M, Kühn, T, Lukanova, A, Boeing, H, Buijsse, B, Klinaki, E, Tsimakidi, C, Naccarati, A, Tagliabue, G, Panico, S, Tumino, R, Palli, D, Bueno-de-Mesquita, H

“…Our objective was to investigate the association between prediagnostic circulating 25-hydroxyvitamin D [25(OH)D] serum levels and the risk of HCC in a prospective, nested case-control study among 520,000 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. …”

Postmenopausal serum sex steroids and risk of hormone receptor-positive and -negative breast cancer: a nested case-control study. by James, R, Lukanova, A, Dossus, L, Becker, S, Rinaldi, S, Tjønneland, A, Olsen, A, Overvad, K, Mesrine, S, Engel, P, Clavel-Chapelon, F, Chang-Claude, J, Vrieling, A, Boeing, H, Schütze, M, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Krogh, V, Panico, S, Tumino, R, Sacerdote, C, Rodríguez, L, Buckland, G

“…In a case-control study nested within the EPIC cohort (European Prospective Investigation into Cancer and Nutrition), estradiol, testosterone, and sex hormone-binding globulin levels were measured in prediagnostic serum samples from postmenopausal women not using hormone replacement therapy at blood donation. …”

Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: A nested case-control study by Kühn, T, Kaaks, R, Becker, S, Eomois, P, Clavel-Chapelon, F, Kvaskoff, M, Dossus, L, Tjønneland, A, Olsen, A, Overvad, K, Chang-Claude, J, Lukanova, A, Buijsse, B, Boeing, H, Trichopoulou, A, Lagiou, P, Bamia, C, Masala, G, Krogh, V, Sacerdote, C, Tumino, R, Mattiello, A, Buckland, G, Sánchez, M, Menéndez, V

Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: a nested case-control study. by Kühn, T, Kaaks, R, Becker, S, Eomois, P, Clavel-Chapelon, F, Kvaskoff, M, Dossus, L, Tjønneland, A, Olsen, A, Overvad, K, Chang-Claude, J, Lukanova, A, Buijsse, B, Boeing, H, Trichopoulou, A, Lagiou, P, Bamia, C, Masala, G, Krogh, V, Sacerdote, C, Tumino, R, Mattiello, A, Buckland, G, Sánchez, M, Menéndez, V

Biomarkers of oxidative stress and risk of developing colorectal cancer: a cohort-nested case-control study in the European Prospective Investigation Into Cancer and Nutrition. by Leufkens, A, van Duijnhoven, F, Woudt, S, Siersema, P, Jenab, M, Jansen, E, Pischon, T, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, M, Clavel-Chapelon, F, Morois, S, Palli, D, Pala, V, Tumino, R, Vineis, P, Panico, S, Kaaks, R, Lukanova, A, Boeing, H, Aleksandrova, K, Trichopoulou, A, Trichopoulos, D, Dilis, V

“…This was examined in a nested case-control study (1,064 CRC cases, 1,064 matched controls) in the European Prospective Investigation Into Cancer and Nutrition cohort (1992-2003). …”

Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. by Aleksandrova, K, Jenab, M, Boeing, H, Jansen, E, Bueno-de-Mesquita, H, Rinaldi, S, Riboli, E, Overvad, K, Dahm, C, Olsen, A, Tjønneland, A, Boutron-Ruault, M, Clavel-Chapelon, F, Morois, S, Palli, D, Krogh, V, Tumino, R, Vineis, P, Panico, S, Kaaks, R, Rohrmann, S, Trichopoulou, A, Lagiou, P, Trichopoulos, D, van Duijnhoven, F

“…The authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using risk-set sampling and matched on study center, age, sex, time of blood collection, fasting status, menopausal status, menstrual cycle phase, and hormone replacement therapy. …”

Haplotype-based analysis of common variation in the acetyl-coA carboxylase alpha gene and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. by Sinilnikova, O, McKay, J, Tavtigian, S, Canzian, F, DeSilva, D, Biessy, C, Monnier, S, Dossus, L, Boillot, C, Gioia, L, Hughes, D, Jensen, M, Overvad, K, Tjonneland, A, Olsen, A, Clavel-Chapelon, F, Chajès, V, Joulin, V, Linseisen, J, Chang-Claude, J, Boeing, H, Dahm, S, Trichopoulou, A, Trichopoulos, D, Koliva, M

“…We used a comprehensive haplotype analysis to examine the contribution of the ACC-alpha common genetic variation (allele frequency >5%) to breast cancer in a case-control study (1,588 cases/2,600 controls) nested within the European Prospective Investigation into Cancer and Nutrition. …”

Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). by Dossus, L, McKay, J, Canzian, F, Wilkening, S, Rinaldi, S, Biessy, C, Olsen, A, Tjønneland, A, Jakobsen, M, Overvad, K, Clavel-Chapelon, F, Boutron-Ruault, M, Fournier, A, Linseisen, J, Lukanova, A, Boeing, H, Fisher, E, Trichopoulou, A, Georgila, C, Trichopoulos, D, Palli, D, Krogh, V, Tumino, R, Vineis, P, Quirós, JR

“…We conducted a case-control study on 1359 breast cancer cases and 2389 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition, to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with anthropometric measures, circulating insulin growth factor I (IGF-I) and insulin-like growth factor-binding protein 3 and breast cancer risk. …”

Smoking as a major risk factor for cervical cancer and pre-cancer: results from the EPIC cohort. by Roura, E, Castellsagué, X, Pawlita, M, Travier, N, Waterboer, T, Margall, N, Bosch, F, de Sanjosé, S, Dillner, J, Gram, I, Tjønneland, A, Munk, C, Pala, V, Palli, D, Khaw, K, Barnabas, R, Overvad, K, Clavel-Chapelon, F, Boutron-Ruault, M, Fagherazzi, G, Kaaks, R, Lukanova, A, Steffen, A, Trichopoulou, A, Trichopoulos, D

“…During a mean follow-up time of 9 years, 261 ICC cases and 804 CIN3/CIS cases were reported. In a nested case-control study, the baseline sera from 609 cases and 1,218 matched controls were tested for L1 antibodies against HPV types 11, 16, 18, 31, 33, 35, 45, 52, 58, and antibodies against Chlamydia trachomatis (CT), and Human Herpes Virus 2 (HHV-2). …”

Smoking as a major risk factor for cervical cancer and pre-cancer: Results from the EPIC cohort by Roura, E, Castellsagué, X, Pawlita, M, Travier, N, Waterboer, T, Margall, N, Bosch, F, De Sanjosé, S, Dillner, J, Gram, I, Tjønneland, A, Munk, C, Pala, V, Palli, D, Khaw, K, Barnabas, R, Overvad, K, Clavel-Chapelon, F, Boutron-Ruault, M, Fagherazzi, G, Kaaks, R, Lukanova, A, Steffen, A, Trichopoulou, A, Trichopoulos, D

“…During a mean follow-up time of 9 years, 261 ICC cases and 804 CIN3/CIS cases were reported. In a nested case-control study, the baseline sera from 609 cases and 1,218 matched controls were tested for L1 antibodies against HPV types 11, 16, 18, 31, 33, 35, 45, 52, 58, and antibodies against Chlamydia trachomatis (CT), and Human Herpes Virus 2 (HHV-2). …”

Prospective seroepidemiologic study on the role of Human Papillomavirus and other infections in cervical carcinogenesis: Evidence from the EPIC cohort by Castellsagué, X, Pawlita, M, Roura, E, Margall, N, Waterboer, T, Bosch, F, De Sanjosé, S, Gonzalez, C, Dillner, J, Gram, I, Tjønneland, A, Munk, C, Pala, V, Palli, D, Khaw, K, Barnabas, R, Overvad, K, Clavel-Chapelon, F, Boutron-Ruault, M, Fagherazzi, G, Kaaks, R, Lukanova, A, Steffen, A, Trichopoulou, A, Trichopoulos, D

“…To evaluate prospectively the association between serological markers of selected infections, including HPV, and risk of developing cervical cancer (CC) and precancer, we performed a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) study that included 184 cases of invasive CC (ICC), 425 cases of cervical intraepithelial neoplasia (CIN) grade 3 or carcinoma in situ (CIS), and 1,218 matched control women. …”

Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC. by Rundle, A, Richie, J, Steindorf, K, Peluso, M, Overvad, K, Raaschou-Nielsen, O, Clavel-Chapelon, F, Linseisen, J, Boeing, H, Trichopoulou, A, Palli, D, Krogh, V, Tumino, R, Panico, S, Bueno-De-Mesquita, H, Peeters, P, Lund, E, Gonzalez, C, Martinez, C, Dorronsoro, M, Barricarte, A, Tormo, M, Quiros, J, Agudo, A, Berglund, G

“…The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. …”

Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) coh... by Duell, E, Travier, N, Lujan-Barroso, L, Dossus, L, Boutron-Ruault, M, Clavel-Chapelon, F, Tumino, R, Masala, G, Krogh, V, Panico, S, Ricceri, F, Redondo, M, Dorronsoro, M, Molina-Montes, E, Huerta, J, Barricarte, A, Khaw, K, Wareham, N, Allen, N, Travis, R, Siersema, P, Peeters, P, Trichopoulou, A, Fragogeorgi, E, Oikonomou, E

“…Then, in a case-control study nested within the EPIC cohort, we examined 12 single nucleotide polymorphisms (SNPs) in CYP17A1 (an essential gene in sex steroid metabolism) for association with pancreatic cancer in women and men (324 cases and 353 controls). …”

The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk by Campa, D, Hüsing, A, McKay, J, Sinilnikova, O, Vogel, U, Tjønneland, A, Overvad, K, Stegger, J, Clavel-Chapelon, F, Chabbert-Buffet, N, Fagherazzi, G, Trichopoulou, A, Zylis, D, Oustoglou, E, Rohrmann, S, Teucher, B, Fisher, E, Boeing, H, Masala, G, Krogh, V, Sacerdote, C, Panico, S, Tumino, R, Onland-Moret, N, Gils, V, Bueno-De-Mesquita, H, Lund, E, Chirlaque, MD, Sala, N, Quirós, JR, Ardanaz, E, Amiano, P, Molina-Montes, E, Hallmans, G, Lenner, P, Travis, R, Key, T, Wareham, N, Khaw, K, Rinaldi, S, Slimani, N, Chajes, V, Siddiq, A, Riboli, E, Kaaks, R, Canzian, F

“…<br/><br/> <b>Methods:</b> we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk.…”

Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers. by Vineis, P, Veglia, F, Garte, S, Malaveille, C, Matullo, G, Dunning, A, Peluso, M, Airoldi, L, Overvad, K, Raaschou-Nielsen, O, Clavel-Chapelon, F, Linseisen, J, Kaaks, R, Boeing, H, Trichopoulou, A, Palli, D, Crosignani, P, Tumino, R, Panico, S, Bueno-De-Mesquita, H, Peeters, P, Lund, E, Gonzalez, C, Martinez, C, Dorronsoro, M

“…PATIENTS AND METHODS: The study has been conducted as a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (409 cancer cases and 757 matched controls). …”

European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection. by Riboli, E, Hunt, K, Slimani, N, Ferrari, P, Norat, T, Fahey, M, Charrondière, U, Hémon, B, Casagrande, C, Vignat, J, Overvad, K, Tjønneland, A, Clavel-Chapelon, F, Thiébaut, A, Wahrendorf, J, Boeing, H, Trichopoulos, D, Trichopoulou, A, Vineis, P, Palli, D, Bueno-De-Mesquita, H, Peeters, P, Lund, E, Engeset, D, González, C

“…First results of case-control studies nested within the cohort are expected early in 2003. …”

Plasma cotinine levels and pancreatic cancer in the EPIC cohort study. by Leenders, M, Chuang, S, Dahm, C, Overvad, K, Ueland, P, Midttun, O, Vollset, SE, Tjønneland, A, Halkjaer, J, Jenab, M, Clavel-Chapelon, F, Boutron-Ruault, M, Kaaks, R, Canzian, F, Boeing, H, Weikert, C, Trichopoulou, A, Bamia, C, Naska, A, Palli, D, Pala, V, Mattiello, A, Tumino, R, Sacerdote, C, van Duijnhoven, F

“…This study on pancreatic cancer, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC cohort), included 146 cases and 146 matched controls. …”

Air pollution and risk of lung cancer in a prospective study in Europe. by Vineis, P, Hoek, G, Krzyzanowski, M, Vigna-Taglianti, F, Veglia, F, Airoldi, L, Autrup, H, Dunning, A, Garte, S, Hainaut, P, Malaveille, C, Matullo, G, Overvad, K, Raaschou-Nielsen, O, Clavel-Chapelon, F, Linseisen, J, Boeing, H, Trichopoulou, A, Palli, D, Peluso, M, Krogh, V, Tumino, R, Panico, S, Bueno-De-Mesquita, H, Peeters, P

“…To estimate the relationship between air pollution and lung cancer, a nested case-control study was set up within EPIC (European Prospective Investigation on Cancer and Nutrition). …”

Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study by Michaud, D, Izard, J, Wilhelm-Benartzi, C, You, D, Grote, V, Tjønneland, A, Dahm, C, Overvad, K, Jenab, M, Fedirko, V, Boutron-Ruault, M, Clavel-Chapelon, F, Racine, A, Kaaks, R, Boeing, H, Foerster, J, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Sacerdote, C, Sieri, S, Palli, D, Tumino, R, Panico, S, Siersema, P

“…Design We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study. …”