Non-deletion haemoglobin H disease in Papua New Guinea. by Hill, A, Thein, S, Mavo, B, Weatherall, D, Clegg, J

“…Analysis of DNA from members of a Melanesian family from Papua New Guinea with haemoglobin (Hb) H disease revealed that all four alpha globin genes are intact in affected subjects. …”

Prevention of cerebral malaria in children in Papua New Guinea by southeast Asian ovalocytosis band 3. by Allen, S, O'Donnell, A, Alexander, N, Mgone, C, Peto, T, Clegg, J, Alpers, M, Weatherall, D

“…We undertook a case-control study of children admitted to hospital in a malarious region of Papua New Guinea. The SAO band 3, detected by the polymerase chain reaction, was present in 0 of 68 children with cerebral malaria compared with six (8.8%) of 68 matched community controls (odds ratio = 0, 95% confidence interval = 0-0.85). …”

Beta thalassemia in Melanesia: association with malaria and characterization of a common variant (IVS-1 nt 5 G----C). by Hill, A, Bowden, D, O'Shaughnessy, D, Weatherall, D, Clegg, J

“…Data on the distribution of beta thalassemia among over 6,000 Melanesians reveals a major difference in the carrier rates between populations in the malarious coastal regions of New Guinea and those living in the historically malaria-free Highlands. …”

A population genetic survey of the haptoglobin polymorphism in Melanesians by DNA analysis. by Hill, A, Bowden, D, Flint, J, Whitehouse, D, Hopkinson, D, Oppenheimer, S, Serjeantson, S, Clegg, J

“…We have determined the haptoglobin (Hp) genotypes of 831 Melanesians from Vanuatu, Papua New Guinea, and New Caledonia by Southern blot analysis of DNA extracted from umbilical cord and peripheral blood samples. …”

α+-Thalassemia protects children against disease caused by other infections as well as malaria by Allen, S, O'Donnell, A, Alexander, N, Alpers, M, Peto, T, Clegg, J, Weatherall, D

“…Therefore, we undertook a prospective case-control study of children with severe malaria on the north coast of Papua New Guinea, where malaria transmission is intense and α+ - thalassemia affects more than 90% of the population. …”

alpha+-Thalassemia protects children against disease caused by other infections as well as malaria. by Allen, S, O'Donnell, A, Alexander, N, Alpers, M, Peto, T, Clegg, J, Weatherall, D

“…Therefore, we undertook a prospective case-control study of children with severe malaria on the north coast of Papua New Guinea, where malaria transmission is intense and alpha+-thalassemia affects more than 90% of the population. …”