The Cardiac Electrophysiology Web Lab by Cooper, J, Scharm, M, Mirams, G

numerical guide to the solution of the bidomain equations of cardiac electrophysiology by Pathmanathan, P, Bernabeu, M, Bordas, R, Cooper, J, Garny, A, Pitt−Francis, J, Whiteley, J, Gavaghan, D

On the application of partial evaluation to the optimisation of cardiac electrophysiological simulations by Cooper, J, McKeever, S, Garny, A

Cellular cardiac electrophysiology modeling with Chaste and CellML by Cooper, J, Spiteri, R, Mirams, G

“…Chaste is an open-source C++ library for computational biology that has well-developed cardiac electrophysiology tissue simulation support. In this paper, we introduce the features available for performing cardiac electrophysiology action potential simulations using a wide range of models from the Physiome repository. …”

Reproducible model development in the cardiac electrophysiology Web Lab by Daly, A, Clerx, M, Beattie, K, Cooper, J, Gavaghan, D, Mirams, G

“…We developed a fully-open online repository (which we termed the Cardiac Electrophysiology Web Lab) which allows users to store and compare the results of applying the same experimental protocol to competing models. …”

Cellular cardiac electrophysiology modelling with Chaste and CellML by Cooper, J, Spiteri, R, Mirams, G

“…Chaste is an open-source C++ library for computational biology that has well-developed cardiac electrophysiology tissue simulation support. In this paper, we introduce the features available for performing cardiac electrophysiology action potential simulations using a wide range of models from the Physiome repository. …”

A numerical guide to the solution of the bidomain equations of cardiac electrophysiology by Pathmanathan, P, Bernabeu, M, Bordas, R, Cooper, J, Garny, A, Pitt-Francis, J, Whiteley, J, Gavaghan, D

A numerical guide to the solution of the bidomain equations of cardiac electrophysiology by Pathmanathan, P, Bernabeu, M, Bordas, R, Cooper, J, Garny, A, Pitt−Francis, J, Whiteley, J, Gavaghan, D

POSTERIORI ERROR ANALYSIS FOR THE USE OF LOOKUP TABLES IN CARDIAC ELECTROPHYSIOLOGY SIMULATIONS by Cooper, J, Whiteley, J, Gavaghan, D

“…A common example is the use of lookup tables to approximate computationally intensive expressions in cardiac electrophysiology cell models, which are given mathematically as systems of ordinary differential equations. …”

A numerical guide to the solution of the bi-domain equations of cardiac electrophysiology. by Pathmanathan, P, Bernabeu, M, Bordas, R, Cooper, J, Garny, A, Pitt-Francis, J, Whiteley, J, Gavaghan, D

A posteriori error analysis for the use of lookup tables in cardiac electrophysiology simulations by Cooper, J, Whiteley, J, Gavaghan, D

A POSTERIORI ERROR ANALYSIS FOR THE USE OF LOOKUP TABLES IN CARDIAC ELECTROPHYSIOLOGY SIMULATIONS by Cooper, J, Whiteley, J, Gavaghan, D

“…A common example is the use of lookup tables to approximate computationally intensive expressions in cardiac electrophysiology cell models, which are given mathematically as systems of ordinary differential equations. …”

Chaste: a case study of parallelisation of an open source finite−element solver with applications to computational cardiac electrophysiology simulation by Bernabeu, M, Southern, J, Wilson, N, Strazdins, P, Cooper, J, Pitt−Francis, J

Chaste: A case study of parallelisation of an open source finite-element solver with applications to computational cardiac electrophysiology simulation by Bernabeu, M, Southern, J, Wilson, N, Strazdins, P, Cooper, J, Pitt-Francis, J

Considerations for the use of cellular electrophysiology models within cardiac tissue simulations. by Cooper, J, Corrias, A, Gavaghan, D, Noble, D

“…The use of mathematical models to study cardiac electrophysiology has a long history, and numerous cellular scale models are now available, covering a range of species and cell types. …”

Chaste: an open source C++ library for computational physiology and biology by Mirams, G, Arthurs, C, Bernabeu, M, Bordas, R, Cooper, J, Corrias, A, Davit, Y, Dunn, S, Fletcher, A, Harvey, D, Marsh, M, Osborne, J, Pathmanathan, P, Pitt−Francis, J, Southern, J, Zemzemi, N, Gavaghan, D

“…Code development has been driven by two initial applications: cardiac electrophysiology and cancer development. A large number of cardiac electrophysiology studies have been enabled and performed, including high-performance computational investigations of defibrillation on realistic human cardiac geometries. …”

Chaste: an open source C++ library for computational physiology and biology by Mirams, G, Arthurs, C, Bernabeu, M, Bordas, R, Cooper, J, Corrias, A, Davit, Y, Dunn, S, Fletcher, A, Harvey, D, Marsh, M, Osborne, J, Pathmanathan, P, Pitt-Francis, J, Southern, J, Zemzem, N, Gavaghan, D

“…Code development has been driven by two initial applications: cardiac electrophysiology and cancer development. A large number of cardiac electrophysiology studies have been enabled and performed, including high-performance computational investigations of defibrillation on realistic human cardiac geometries. …”

Chaste: an open source C++ library for computational physiology and biology by Mirams, G, Arthurs, C, Bernabeu, M, Bordas, R, Cooper, J, Corrias, A, Davit, Y, Dunn, S, Fletcher, A, Harvey, D, Marsh, M, Osborne, J, Pathmanathan, P, Pitt-Francis, J, Southern, J, Zemzemi, N, Gavaghan, D

“…Code development has been driven by two initial applications: cardiac electrophysiology and cancer development. A large number of cardiac electrophysiology studies have been enabled and performed, including high-performance computational investigations of defibrillation on realistic human cardiac geometries. …”

Models of the cardiac L-type calcium current: a quantitative review by Agrawal, A, Wang, K, Polonchuk, L, Cooper, J, Hendrix, M, Gavaghan, DJ, Mirams, GR, Clerx, M

“…The L-type calcium current ( ICaL$$ {I}_{\mathrm{CaL}} $$ ) plays a critical role in cardiac electrophysiology, and models of ICaL$$ {I}_{\mathrm{CaL}} $$ are vital tools to predict arrhythmogenicity of drugs and mutations. …”

Connecting models to data in multiscale multicellular tissue simulations by Cooper, J, Osborne, J

“…In this paper we describe how work we have done to address these issues in the domain of cardiac electrophysiology can be applied in a completely different field: multicellular models of intestinal crypts, with cells treated as discrete entities, and the sub-cellular, cellular, and tissue scales interacting. …”