Oocyte activation and fertilisation: crucial contributors from the sperm and oocyte by Yeste, M, Jones, C, Amdani, S, Coward, K

New insights into the mechanism of egg activation in fish by Coward, K, Parrington, J

“…The commercial culture of several important species of fish has long been associated with productivity problems generally attributable to fertilisation rates, hatching rates, and embryonic development. …”

Potential effects of assisted reproductive technology upon the abundance and localisation of two vital sperm proteins by Yelumalai, S, Dr Suseela Yelumalai

“…<p>Assisted reproductive technology (ART) uses advanced techniques such as in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI) to combat human infertility. …”

Artificial oocyte activation (AOA) and phospholipase C zeta (PLCζ) in assisted reproductive technology (ART) by Meng, X

“…<p>Oocyte activation deficiency (OAD) is the main cause of total fertilisation failure/low fertilisation rate in assisted reproductive technology (ART). …”

Does advancing male age influence the expression levels and localisation patterns of phospholipase C zeta (PLCζ) in human sperm? by Yeste, M, Jones, C, Amdani, S, Yelumalai, S, Mounce, G, Martins da Silva, S, Child, T, Coward, K

“…One fundamental role of sperm is to activate the oocyte at fertilisation, a process initiated by phospholipase C zeta (PLCζ), a sperm-specific protein. …”

Phospholipase C zeta and male infertility: clinical update and topical developments by Coward, K, Amdani, S, Yeste, M, Jones, C

“…Oocyte activation deficiency (OAD) and total fertilisation failure (TFF) are known causes of infertility and have both been linked to abnormalities in the structure, expression, and localisation pattern of PLCζ in human sperm. …”

The oocyte-activation factor, phospholipase C zeta (PLCζ): clinical prognosis, diagnosis, and treatment of oocyte activation deficiency by Amdani, S

“…<p>Oocyte activation deficiency (OAD) is an infertile condition observed in patients who have experienced recurrent total fertilisation failure (TFF) following intracytoplasmic sperm injection treatment. …”

In vivo gene transfer into the testis by electroporation and viral infection--a novel way to study testis and sperm function. by Parrington, J, Coward, K, Hibbitt, O, Kubota, H, Young, C, McIlhinney, J, Jones, O

“…The study of gene function in testis and sperm has been greatly assisted by creation of transgenic mice by injection of a transgene into the fertilised egg. However this approach is costly and laborious and is not applicable to other species of importance for the study of sperm function, such as the hamster. …”