Studies on the mechanisms by which clenbuterol, a beta-adrenoceptor agonist, enhances 5-HT-mediated behaviour and increases metabolism of 5-HT in the brain of the rat. by Nimgaonkar, V, Green, A, Cowen, P, Heal, D, Grahame-Smith, D, Deakin, J

“…The head twitch response in mice produced by injection of 5-hydroxytryptophan (100 mg/kg i.p.) and carbidopa (25 mg/kg i.p.) was enhanced by administration of clenbuterol (0.5 mg/kg i.p.), a beta-adrenoceptor agonist. …”

β-Adrenoceptor agonists enhance 5-hydroxytryptamine-mediated behavioural responses by Cowen, P, Grahame-Smith, D, Green, A, Heal, D

“…The β-adrenoceptor agonists, salbutamol, terbutaline and clenbuterol, were investigated for their effect on 5-hydroxytryptamine-mediated (5-HT) hyperactivity. …”

beta-Adrenoceptor agonists enhance 5-hydroxytryptamine-mediated behavioural responses. by Cowen, P, Grahame-Smith, D, Green, A, Heal, D

“…The beta-adrenoceptor agonists, salbutamol, terbutaline and clenbuterol, were investigated for their effect on 5-hydroxytryptamine-mediated (5-HT) hyperactivity. 2 The lipophilic beta-adrenoceptor agonist, clenbuterol (5 mg/kg) enhanced the behaviours induced by quipazine (25 mg/kg), including headweaving, forepaw treading and hind-limb abduction and thus increased automated activity recording. …”

The effect of chronic antidepressant administration on beta-adrenoceptor function of the rat pineal. by Cowen, P, Fraser, S, Grahame-Smith, D, Green, A, Stanford, C

“…The beta-adrenoceptor agonist, clenbuterol (5 mg kg(-1) for 14 days), also attenuated the increase in pineal melatonin produced by isoprenaline.3 In contrast, chronic administration of the selective 5-HT uptake inhibitor, fluoxetine (10 mg kg(-1) for 10 days), or the antidepressants, iprindole and mianserin (both 20 mg kg(-1) for 14 days), which do not inhibit monoamine uptake, failed to reduce the increase in pineal melatonin following isoprenaline. …”