Short-term antidepressant treatment and facial processing. Functional magnetic resonance imaging study. by Norbury, R, Mackay, C, Cowen, P, Goodwin, G, Harmer, C

“…We used functional magnetic resonance imaging to investigate the effects of short-term treatment with reboxetine, a selective noradrenaline reuptake inhibitor, on emotional facial processing in healthy volunteers. …”

Cerebellar responses during anticipation of noxious stimuli in subjects recovered from depression. Functional magnetic resonance imaging study. by Smith, K, Ploghaus, A, Cowen, P, McCleery, J, Goodwin, G, Smith, S, Tracey, I, Matthews, P

“…AIMS: To test whether women recovered from depression show abnormal brain activity in functional magnetic resonance imaging (fMRI) during a conditioning paradigm with a noxious pain stimulus. …”

A functional magnetic resonance imaging study of verbal working memory in young people at increased familial risk of depression by Mannie, Z, Harmer, C, Cowen, P, Norbury, R

“…Participants performed a verbal working memory task of varying cognitive load (n-back) while undergoing functional magnetic resonance imaging scanning. We used multiple regression analyses to assess overall capacity (1-, 2-, 3-back vs. 0-back) as well as linear and quadratic modulation of cognitive demand. …”

When less is more: a functional magnetic resonance imaging study of verbal working memory in remitted depressed patients. by Norbury, R, Godlewska, B, Cowen, P

“…To address this question, the current study employed functional magnetic resonance imaging (fMRI), in combination with a simple verbal n-back task, in a cohort of unmedicated remitted depressed patients. …”

A functional magnetic resonance imaging study of verbal working memory in young people at increased familial risk of depression. by Mannie, Z, Harmer, C, Cowen, P, Norbury, R

“…Participants performed a verbal working memory task of varying cognitive load (n-back) while undergoing functional magnetic resonance imaging scanning. We used multiple regression analyses to assess overall capacity (1-, 2-, 3-back vs. 0-back) as well as linear and quadratic modulation of cognitive demand. …”

Increased neural response to fear in patients recovered from depression: a 3T functional magnetic resonance imaging study. by Norbury, R, Selvaraj, S, Taylor, M, Harmer, C, Cowen, P

“…METHOD: We used functional magnetic resonance imaging to examine neural responses to emotional faces in a facial expression-matching task in 16 unmedicated recovered depressed patients and 21 healthy controls. …”

Decreased neural response to fear after a short-term SSRI treatment: a 3T functional magnetic resonance imaging study by Godlewska, B, Norbury, R, Selveraj, S, Cowen, P

Pramipexole enhances reward learning by preserving value estimates by Halahakoon, DC, Kaltenboeck, A, Martens, M, Geddes, JG, Harmer, CJ, Cowen, P, Browning, M

“…Participants completed a probabilistic instrumental learning task before and after the pharmacological intervention, with functional magnetic resonance imaging data collected at the second visit. …”

Acute angiotensin II receptor blockade facilitates parahippocampal processing during memory encoding in high-trait-anxious individuals by Shkreli, L, Thoroddsen, T, Kobelt, M, Martens, MAG, Browning, M, Harmer, CJ, Cowen, P, Reinecke, A

“…At drug peak level, participants encoded images of animals and landscapes before undergoing functional magnetic resonance imaging, where they viewed the encoded familiar images and unseen novel images to be memorized and classified as animals/landscapes. …”

A cognitive neuropsychological model of antidepressant drug action. by Pringle, A, Browning, M, Cowen, P, Harmer, C

“…Evidence from behavioural and functional magnetic resonance imaging studies supports this hypothesis. …”

A cognitive neuropsychological model of antidepressant drug action. by Pringle, A, Browning, M, Cowen, P, Harmer, C

“…Evidence from behavioural and functional magnetic resonance imaging studies supports this hypothesis. …”

Short-term antidepressant treatment modulates amygdala response to happy faces. by Norbury, R, Taylor, M, Selvaraj, S, Murphy, SE, Harmer, C, Cowen, P

“…OBJECTIVES: Here we used functional magnetic resonance imaging in a double-blind, randomised, placebo-controlled between-groups design to investigate the effects of short-term (7-10 days) treatment with the selective serotonin reuptake inhibitor, citalopram, on the amygdala response to positive and negative facial expressions in healthy volunteers. …”

Effect of a single dose of citalopram on amygdala response to emotional faces. by Murphy, SE, Norbury, R, O'Sullivan, U, Cowen, P, Harmer, C

“…Effects on the processing of facial expressions were assessed 3 h later using functional magnetic resonance imaging. RESULTS: Volunteers treated with citalopram displayed a significantly reduced amygdala response to fearful facial expressions compared with placebo. …”

Affective modulation of anterior cingulate cortex in young people at increased familial risk of depression. by Mannie, Z, Norbury, R, Murphy, SE, Inkster, B, Harmer, C, Cowen, P

“…METHOD: Eighteen young people (mean age 19.8 years) with no personal history of depression but with a biological parent with a history of major depression (FH+ participants) and 16 controls (mean age 19.9 years) underwent functional magnetic resonance imaging while completing an emotional counting Stroop task. …”

β-Adrenoceptor blockade modulates fusiform gyrus activity to black versus white faces by Terbeck, S, Kahane, G, Mctavish, S, McCutcheon, R, Hewstone, M, Savulescu, J, Chesterman, L, Cowen, P, Norbury, R

“…Materials and method The current study used functional magnetic resonance imaging (fMRI) in order to determine the neural correlates of this effect. …”

Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action. by Harmer, C, Goodwin, G, Cowen, P

“…METHOD: We examined key published findings that explored the effects of antidepressants on behavioural and functional magnetic resonance imaging (fMRI) measures of emotional processing. …”

Frontolimbic responses to emotional faces in young people at familial risk of depression. by Mannie, Z, Taylor, M, Harmer, C, Cowen, P, Norbury, R

“…METHODS: We used a block designed functional magnetic resonance imaging to measure the neural responses to a task involving the matching of emotional facial expressions in 29 young people (age 16-21 years) who had a biological parent with a history of major depression, and 30 age- and gender-matched controls. …”

Neural response to angry and disgusted facial expressions in bulimia nervosa. by Ashworth, F, Pringle, A, Norbury, R, Harmer, C, Cowen, P, Cooper, M

“…METHOD: Participants were 12 medication-free women with BN in an acute episode (mean age 24 years), and 16 age-, gender- and IQ-matched healthy volunteers (HVs). Functional magnetic resonance imaging (fMRI) was used to examine neural responses to angry and disgusted facial expressions. …”

Neural processing of reward and punishment in young people at increased familial risk of depression. by Mccabe, C, Woffindale, C, Harmer, C, Cowen, P

“…METHODS: We therefore used functional magnetic resonance imaging to examine the neural responses to pleasant and aversive sights and tastes in 25 young people (16-21 years of age) with a biological parent with depression and 25 age- and gender-matched control subjects. …”

The effects of reboxetine on emotional processing in healthy volunteers: an fMRI study. by Norbury, R, Mackay, C, Cowen, P, Goodwin, G, Harmer, C

“…The current study, therefore, used functional magnetic resonance imaging (fMRI) to map brain systems activated during successful categorization and subsequent recognition of self-referent positive and negative personality characteristics in healthy volunteers following short-term (7 days) repeated administration of the selective noradrenergic reuptake inhibitor reboxetine. …”