Efficacy of HDAC Inhibitors Belinostat and Panobinostat against Cisplatin-Sensitive and Cisplatin-Resistant Testicular Germ Cell Tumors by João Lobo, Catarina Guimarães-Teixeira, Daniela Barros-Silva, Vera Miranda-Gonçalves, Vânia Camilo, Rita Guimarães, Mariana Cantante, Isaac Braga, Joaquina Maurício, Christoph Oing, Friedemann Honecker, Daniel Nettersheim, Leendert H. J. Looijenga, Rui Henrique, Carmen Jerónimo

Subjects: “…testicular germ cell tumors…”
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Molecular characterization of the CXCR4 / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates by Gamal A. Wakileh, Philipp Bierholz, Mara Kotthoff, Margaretha A. Skowron, Felix Bremmer, Alexa Stephan, Stephanie M. Anbuhl, Raimond Heukers, Martine J. Smit, Philipp Ströbel, Daniel Nettersheim

Subjects: “…Germ cell tumors…”
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Targeting EpCAM by a Bispecific Trifunctional Antibody Exerts Profound Cytotoxic Efficacy in Germ Cell Tumor Cell Lines by Stefan Schönberger, Daniela Kraft, Daniel Nettersheim, Hubert Schorle, Anna Casati, Rogerio B. Craveiro, Mahsa Mir Mohseni, Gabriele Calaminus, Dagmar Dilloo

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Targeting CLDN6 in germ cell tumors by an antibody-drug-conjugate and studying therapy resistance of yolk-sac tumors to identify and screen specific therapeutic options by Margaretha A. Skowron, Mara Kotthoff, Felix Bremmer, Katja Ruhnke, Fatma Parmaksiz, Annika Richter, Stefan Küffer, Kirsten Reuter-Jessen, Stella Pauls, Anja Stefanski, Philipp Ströbel, Kai Stühler, Daniel Nettersheim

Subjects: “…Germ cell tumors…”
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TCam-2 Cells Deficient for SOX2 and FOXA2 Are Blocked in Differentiation and Maintain a Seminoma-Like Cell Fate In Vivo by Daniel Nettersheim, Saskia Vadder, Sina Jostes, Alena Heimsoeth, Hubert Schorle

Subjects: “…germ cell tumors…”
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<i>ARID1A</i> Regulates Transcription and the Epigenetic Landscape via POLE and DMAP1 While <i>ARID1A</i> Deficiency or Pharmacological Inhibition Sensitizes Germ Cell Tumor Cells to ATR Inhibition by Lukas Kurz, Alissa Miklyaeva, Margaretha A. Skowron, Nina Overbeck, Gereon Poschmann, Teresa Becker, Katharina Eul, Thomas Kurz, Stefan Schönberger, Gabriele Calaminus, Kai Stühler, Emily Dykhuizen, Peter Albers, Daniel Nettersheim

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BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma. by Daniel Nettersheim, Sina Jostes, Rakesh Sharma, Simon Schneider, Andrea Hofmann, Humberto J Ferreira, Per Hoffmann, Glen Kristiansen, Manel B Esteller, Hubert Schorle

“…Type II germ cell cancers (GCC) can be subdivided into seminomas and non-seminomas. …”
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Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2 by Laura Schmitt, Ilka Lechtenberg, Daniel Drießen, Hector Flores-Romero, Margaretha A. Skowron, Marlena Sekeres, Julia Hoppe, Karina S. Krings, Tanya R. Llewellyn, Christoph Peter, Björn Stork, Nan Qin, Sanil Bhatia, Daniel Nettersheim, Gerhard Fritz, Ana J. García-Sáez, Thomas J. J. Müller, Sebastian Wesselborg

“…In addition, meriolins were capable of inducing cell death in imatinib-resistant K562 and KCL22 chronic myeloid leukemia cells as well as in cisplatin-resistant J82 urothelial carcinoma and 2102EP germ cell tumor cells. Given the frequent inactivation of the mitochondrial apoptosis pathway by tumor cells, such as through overexpression of antiapoptotic Bcl-2, meriolin derivatives emerge as promising therapeutic agents for overcoming treatment resistance.…”
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Filamin A Orchestrates Cytoskeletal Structure, Cell Migration and Stem Cell Characteristics in Human Seminoma TCam-2 Cells by Harald Welter, Carola Herrmann, Thomas Fröhlich, Florian Flenkenthaler, Katja Eubler, Hubert Schorle, Daniel Nettersheim, Artur Mayerhofer, Annette Müller-Taubenberger

“…In summary, our data suggest that FLNA is crucially involved in balancing stem cell characteristics and invasive properties in human seminoma cells and possibly human testicular germ cells.…”
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