Screening, characterisation and prevention of Hepatitis B virus (HBV) co-infection in HIV-positive children in South Africa by Jooste, P, van Zyl, A, Adland, E, Daniels, S, Hattingh, L, Brits, A, Wareing, S, Goedhals, D, Jeffery, K, Andersson, M, Goulder, P, Matthews, P

“…<br/><br/> Objectives <br/> We set out to implement a screening program for HBV among HIV-infected children and adolescents in Kimberley, South Africa. Our aims were to demonstrate that screening is feasible and sustainable, to establish the prevalence of HBV, to characterise the HBV cases we identified, and to inform discussion about the infant vaccination schedule. …”

PARV4 prevalence, phylogeny, immunology and coinfection with HIV, HBV and HCV in a multicentre African cohort. by Sharp, C, Gregory, W, Hattingh, L, Malik, A, Adland, E, Daniels, S, van Zyl, A, Carlson, J, Wareing, S, Ogwu, A, Shapiro, R, Riddell, L, Chen, F, Ndung'u, T, Goulder, P, Klenerman, P, Simmonds, P, Jooste, P, Matthews, P

“…</p> <h4>Methods</h4> <p>To further explore the characteristics of PARV4 in this setting, with a particular focus on the prevalence and significance of coinfection, we screened a cohort of 695 individuals recruited from Durban and Kimberley (South Africa) and Gaborone (Botswana) for PARV4 IgG and DNA, as well as documenting HIV, HBV and HCV status.…”

HBV vaccination and PMTCT as elimination tools in the presence of HIV: insights from a clinical cohort and dynamic model by McNaughton, A, Lourenco, J, Hattingh, L, Adland, E, Daniels, S, Van Zyl, A, Akiror, C, Wareing, S, Jeffery, K, Ansari, M, Klenerman, P, Goulder, P, Gupta, S, Jooste, P, Matthews, P

“…We first investigated the current impact of paediatric vaccination in a cohort of children with and without HIV infection in Kimberley, South Africa. Second, we used these data to inform a new parsimonious model to simulate the ongoing impact of preventive interventions. …”