Correlates of Person-Specific Rates of Change in Sensor-Derived Physical Activity Metrics of Daily Living in the Rush Memory and Aging Project by Aron S. Buchman, Tianhao Wang, Shahram Oveisgharan, Andrea R. Zammit, Lei Yu, Peng Li, Kun Hu, Jeffrey M. Hausdorff, Andrew S. P. Lim, David A. Bennett

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Multimodal lifestyle engagement patterns support cognitive stability beyond neuropathological burden by Emily W. Paolillo, Rowan Saloner, Anna VandeBunte, Shannon Lee, David A. Bennett, Kaitlin B. Casaletto

“…Methods Participants included 2059 older adults enrolled in the longitudinal Memory and Aging Project (MAP) at the Rush Alzheimer’s Disease Center; none of whom had dementia at baseline (73% no cognitive impairment (NCI), 27% mild cognitive impairment [MCI]). …”
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Relationship between objectively measured physical activity on neuropathology and cognitive outcomes in older adults: Resistance versus resilience? by Molly Memel, Aron S. Buchman, David A. Bennett, Kaitlin Casaletto

“…Methods Five hundred thirteen Rush Memory and Aging Project (MAP) decedents completed longitudinal actigraphy monitoring, cognitive testing, and neuropathological examination. …”
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How Does Psychosocial Behavior Contribute to Cognitive Health in Old Age? by Robert S. Wilson, David A. Bennett

“…We then examine an ongoing study that includes several of the key design elements, the Rush Memory and Aging Project. In this longitudinal clinical-pathological cohort study, indicators of personality, social connectedness, and psychological well-being were shown to predict late-life cognitive outcomes. …”
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Digital quantification of the MMSE interlocking pentagon areas: a three-stage algorithm by Namhee Kim, Timothy Truty, S. Duke Han, Moonseong Heo, Aron S. Buchman, David A. Bennett, Shinya Tasaki

“…A set of 497 PCTs from 84 participants including their baseline and follow-up PCTs from the Rush Memory and Aging Project was selected blinded about their cognitive and clinical status. …”
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Adherence to MIND Diet, Genetic Susceptibility, and Incident Dementia in Three US Cohorts by Thanh Huyen T. Vu, Todd Beck, David A. Bennett, Julie A. Schneider, Kathleen M. Hayden, Aladdin H. Shadyab, Kumar B. Rajan, Martha Clare Morris, Marilyn C. Cornelis

“…We used three ongoing US cohorts: Chicago Health and Aging Project (CHAP, <i>n</i> = 2449), Rush Memory and Aging Project (MAP, <i>n</i> = 725), and Women’s Health Initiative Memory Study (WHIMS, <i>n</i> = 5308). …”
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Association of Cardiovascular Risk Burden With Risk and Progression of Disability: Mediating Role of Cardiovascular Disease and Cognitive Decline by Kaiwang Cui, Ruixue Song, Hui Xu, Ying Shang, Xiuying Qi, Aron S. Buchman, David A. Bennett, Weili Xu

“…Methods and Results A total of 1480 older adults with no disabilities (mean age=79.32±7.38 years) from the Rush Memory and Aging Project were followed for up to 21 years. …”
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Evaluating genomic signatures of aging in brain tissue as it relates to Alzheimer’s disease by Megan T. Lynch, Margaret A. Taub, Jose M. Farfel, Jingyun Yang, Peter Abadir, Philip L. De Jager, Francine Grodstein, David A. Bennett, Rasika A. Mathias

“…We examined dorsolateral prefrontal cortex (DLPFC) tissue from N = 367 participants of the Religious Orders Study (ROS) or the Rush Memory and Aging Project (MAP). TL and mtDNAcn were estimated from whole genome sequencing (WGS) data and cortical clock age was computed on 347 CpG sites. …”
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CHRNA5 links chandelier cells to severity of amyloid pathology in aging and Alzheimer’s disease by Jonas Rybnicek, Yuxiao Chen, Milos Milic, Earvin S. Tio, JoAnne McLaurin, Timothy J. Hohman, Philip L. De Jager, Julie A. Schneider, Yanling Wang, David A. Bennett, Shreejoy Tripathy, Daniel Felsky, Evelyn K. Lambe

“…Therefore, we investigate the nicotinic α5 gene CHRNA5 and the impact of relevant single nucleotide polymorphisms (SNPs) in prefrontal cortex from 922 individuals with matched genotypic and post-mortem RNA sequencing in the Religious Orders Study and Memory and Aging Project (ROS/MAP). We find that a genotype robustly linked to increased expression of CHRNA5 (rs1979905A2) predicts significantly reduced cortical β-amyloid load. …”
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A Genetic Study of Cerebral Atherosclerosis Reveals Novel Associations with <i>NTNG1</i> and CNOT3 by Selina M. Vattathil, Yue Liu, Nadia V. Harerimana, Adriana Lori, Ekaterina S. Gerasimov, Thomas G. Beach, Eric M. Reiman, Philip L. De Jager, Julie A. Schneider, David A. Bennett, Nicholas T. Seyfried, Allan I. Levey, Aliza P. Wingo, Thomas S. Wingo

“…To examine the association of common single nucleotide polymorphisms with cerebral atherosclerosis severity, we conducted a genomewide association study (GWAS) using data collected as part of two community-based cohort studies in the United States, the Religious Orders Study (ROS) and Rush Memory and Aging Project (MAP). Both studies enroll older individuals and exclude participants with signs of dementia at baseline. …”
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Trajectories of olfactory identification preceding incident mild cognitive impairment and dementia: a longitudinal studyResearch in context by Jie Guo, Abigail Dove, Jiao Wang, Erika J. Laukka, Ingrid Ekström, Michelle M. Dunk, David A. Bennett, Weili Xu

“…Methods: Within the Rush Memory and Aging Project, 1318 dementia-free older adults were followed annually for up to 11 years. …”
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Volumetric brain correlates of gait associated with cognitive decline in community-dwelling older adults by Victoria N. Poole, Victoria N. Poole, Shahram Oveisgharan, Shahram Oveisgharan, Lei Yu, Lei Yu, Robert J. Dawe, Robert J. Dawe, Sue E. Leurgans, Sue E. Leurgans, Sue E. Leurgans, Shengwei Zhang, Konstantinos Arfanakis, Konstantinos Arfanakis, Aron S. Buchman, Aron S. Buchman, David A. Bennett, David A. Bennett

“…ObjectiveTo determine the extent to which the regional brain volumes associated with slow gait speed can inform subsequent cognitive decline in older adults from the Rush Memory and Aging Project.ApproachWe utilized deformation-based morphometry (DBM) in a whole-brain exploratory approach to identify the regional brain volumes associated with gait speed assessed over a short distance during an in-home assessment. …”
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Subjective socioeconomic status is associated with risk aversion in a community-based cohort of older adults without dementia by Gali H. Weissberger, S. Duke Han, S. Duke Han, S. Duke Han, S. Duke Han, Lei Yu, Lei Yu, Lisa L. Barnes, Lisa L. Barnes, Lisa L. Barnes, Melissa Lamar, Melissa Lamar, David A. Bennett, David A. Bennett, Patricia A. Boyle, Patricia A. Boyle

“…Participants were 933 older adults without dementia from the Rush Memory and Aging Project (MAP) or Minority Aging Research Study (MARS), two longitudinal epidemiologic studies of aging. …”
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miR-129-5p as a biomarker for pathology and cognitive decline in Alzheimer’s disease by Sang-Won Han, Jung-Min Pyun, Paula J. Bice, David A. Bennett, Andrew J. Saykin, Sang Yun Kim, Young Ho Park, Kwangsik Nho

“…Methods We performed co-expression network analysis to identify network modules associated with AD, its neuropathology markers, and cognition using brain tissue miRNA profiles from the Religious Orders Study and Rush Memory and Aging Project (ROS/MAP) (N = 702) as a discovery dataset. …”
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Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities by Yuriko Katsumata, Lincoln M. Shade, Timothy J. Hohman, Julie A. Schneider, David A. Bennett, Jose M. Farfel, Walter A. Kukull, David W. Fardo, Peter T. Nelson

“…Separate data were obtained from the harmonized Religious Orders Study and the Rush Memory and Aging Project (ROSMAP). A total of 4811 European participants had at least ADNC neuropathology data and also genotype data available; data were meta-analyzed across cohorts. …”
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Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer’s disease at CPT1A locus by Chloé Sarnowski, Tianxiao Huan, Yiyi Ma, Roby Joehanes, Alexa Beiser, Charles S. DeCarli, Nancy L. Heard-Costa, Daniel Levy, Honghuang Lin, Ching-Ti Liu, Chunyu Liu, James B. Meigs, Claudia L. Satizabal, Jose C. Florez, Marie-France Hivert, Josée Dupuis, Philip L. De Jager, David A. Bennett, Sudha Seshadri, Alanna C. Morrison

“…We identified DNA methylation markers associated with IR at the genome-wide level accounting for multiple testing (P < 1.1 × 10−7) and evaluated their association with neurological traits in participants from the FHS (N = 3040) and the Religious Orders Study/Memory and Aging Project (ROSMAP, N = 707). DNA methylation profiles were measured in blood (FHS) or dorsolateral prefrontal cortex (ROSMAP) using the Illumina HumanMethylation450 BeadChip. …”
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