Comparative Analysis, Structural Insights, and Substrate/Drug Interaction of CYP128A1 in <i>Mycobacterium tuberculosis</i> by Nokwanda Samantha Ngcobo, Zinhle Edith Chiliza, Wanping Chen, Jae-Hyuk Yu, David R. Nelson, Jack A. Tuszynski, Jordane Preto, Khajamohiddin Syed

“…In all MTBC species (except one) CYP128 P450s belong to subfamily A, whereas subfamily B is predominant in another four mycobacterial category species. …”
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A cytochrome P450 insecticide detoxification mechanism is not conserved across the Megachilidae family of bees by Angela Hayward, Benjamin J. Hunt, Julian Haas, Ellie Bushnell‐Crowther, Bartlomiej J. Troczka, Adam Pym, Katherine Beadle, Jeremy Field, David R. Nelson, Ralf Nauen, Chris Bass

“…The presence of these P450s, belonging or closely related to the CYP9Q subfamily (CYP9Q‐related), is generally well conserved across the diversity of bees. …”
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Saprophytic to Pathogenic Mycobacteria: Loss of Cytochrome P450s Vis a Vis Their Prominent Involvement in Natural Metabolite Biosynthesis by Ntokozo Minenhle Zondo, Tiara Padayachee, David R. Nelson, Khajamohiddin Syed

“…The study revealed the presence of 62,815 P450s that can be grouped into 182 P450 families and 345 subfamilies. Blooming (the presence of more than one copy of the same gene) and expansion (presence of the same gene in many species) were observed at the family and subfamily levels. …”
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Comparative Analyses of Cytochrome P450s and Those Associated with Secondary Metabolism in <i>Bacillus</i> Species by Bongumusa Comfort Mthethwa, Wanping Chen, Mathula Lancelot Ngwenya, Abidemi Paul Kappo, Puleng Rosinah Syed, Rajshekhar Karpoormath, Jae-Hyuk Yu, David R. Nelson, Khajamohiddin Syed

“…<i>Bacillus</i> species were found to have lower numbers of P450s, P450 families and subfamilies, and a lower P450 diversity percentage compared to mycobacterial species. …”
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Evolution of Cytochrome P450 Enzymes and Their Redox Partners in Archaea by Phelelani Erick Ngcobo, Bridget Valeria Zinhle Nkosi, Wanping Chen, David R. Nelson, Khajamohiddin Syed

“…Genome-wide analysis revealed 1204 P450s belonging to 34 P450 families and 112 P450 subfamilies, where some families and subfamilies are expanded in archaea. …”
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Pezizomycetes Genomes Reveal Diverse P450 Complements Characteristic of Saprotrophic and Ectomycorrhizal Lifestyles by Nomfundo Ntombizinhle Nsele, Tiara Padayachee, David R. Nelson, Khajamohiddin Syed

“…Genome-wide data mining, annotation, and phylogenetic analysis of P450s in 19 Pezizomycetes revealed 668 P450s that can be grouped into 153 P450 families and 245 P450 subfamilies. Only four P450 families, namely, CYP51, CYP61, CYP5093, and CYP6001, are conserved across 19 Pezizomycetes, indicating their important role in these species. …”
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Evolution of five environmentally responsive gene families in a pine‐feeding sawfly, Neodiprion lecontei (Hymenoptera: Diprionidae) by Kim L. Vertacnik, Danielle K. Herrig, R. Keating Godfrey, Tom Hill, Scott M. Geib, Robert L. Unckless, David R. Nelson, Catherine R. Linnen

“…We find evidence of recent expansions of bitter gustatory receptor, clan 3 cytochrome P450, olfactory receptor, and antimicrobial peptide subfamilies, with strong evidence of positive selection among paralogs in a clade of gustatory receptors possibly involved in the detection of bitter compounds. …”
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In Silico Analysis of P450s and Their Role in Secondary Metabolism in the Bacterial Class <i>Gammaproteobacteria</i> by Ntombizethu Nokuphiwa Msomi, Tiara Padayachee, Nomfundo Nzuza, Puleng Rosinah Syed, Justyna Dorota Kryś, Wanping Chen, Dominik Gront, David R. Nelson, Khajamohiddin Syed

“…A total of 277 P450s found in 169 species grouped into 84 P450 families and 105 P450 subfamilies, where 38 new P450 families were found. …”
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Ancient Bacterial Class <i>Alphaproteobacteria</i> Cytochrome P450 Monooxygenases Can Be Found in Other Bacterial Species by Nomfundo Nzuza, Tiara Padayachee, Puleng Rosinah Syed, Justyna Dorota Kryś, Wanping Chen, Dominik Gront, David R. Nelson, Khajamohiddin Syed

“…Genome data mining and annotation of P450s in 599 alphaproteobacterial species belonging to 164 genera revealed the presence of P450s in only 241 species belonging to 82 genera that are grouped into 143 P450 families and 214 P450 subfamilies, including 77 new P450 families. Alphaproteobacterial species have the highest average number of P450s compared to <i>Firmicutes</i> species and cyanobacterial species. …”
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Genome-Wide Analysis of the Cytochrome P450 Monooxygenases in the Lichenized Fungi of the Class <i>Lecanoromycetes</i> by Gugulethu Mlambo, Tiara Padayachee, David R. Nelson, Khajamohiddin Syed

“…A genome-wide analysis of P450s in five lichens from the fungal class <i>Lecanoromycetes</i> revealed the presence of 434 P450s that are grouped into 178 P450 families and 345 P450 subfamilies. The study indicated that none of the P450 families bloomed, and 15 P450 families were conserved in all five <i>Lecanoromycetes</i>. …”
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More P450s Are Involved in Secondary Metabolite Biosynthesis in <i>Streptomyces</i> Compared to <i>Bacillus</i>, <i>Cyanobacteria</i>, and <i>Mycobacterium</i> by Fanele Cabangile Mnguni, Tiara Padayachee, Wanping Chen, Dominik Gront, Jae-Hyuk Yu, David R. Nelson, Khajamohiddin Syed

“…Our analyses revealed the presence of 5460 P450s, grouped into 253 families and 698 subfamilies. The CYP107 family was found to be conserved and highly populated in <i>Streptomyces</i> and <i>Bacillus</i> species, indicating its key role in the synthesis of secondary metabolites. …”
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An Unprecedented Number of Cytochrome P450s Are Involved in Secondary Metabolism in <i>Salinispora</i> Species by Nsikelelo Allison Malinga, Nomfundo Nzuza, Tiara Padayachee, Puleng Rosinah Syed, Rajshekhar Karpoormath, Dominik Gront, David R. Nelson, Khajamohiddin Syed

“…The study revealed the presence of 2643 P450s that can be grouped into 45 families and 103 subfamilies. CYP107 and CYP125 families are conserved, and CYP105 and CYP107 families are bloomed (a P450 family with many members) across <i>Salinispora</i> species. …”
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