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Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis
Published 2018“…Here we show that unprecedented direct access to different, homogeneously glucosylated states of GYG can be accomplished through a palladium-mediated enzyme activation ‘shunt’ process using on-protein C–C bond formation. …”
Journal article -
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Palladium-mediated site-selective Suzuki-Miyaura protein modification at genetically encoded aryl halides.
Published 2011“…Site-specific genetic incorporation of unnatural p-halophenylalanine amino acid residues as 'tags' coupled with Pd(0)-mediated Suzuki-Miyuara 'modification' has been enabled by discovery of an effective small molecule palladium scavenger.…”
Journal article -
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Suzuki-Miyaura cross-coupling on protein substrates using a novel palladium-pyrimidine catalyst
Published 2011Conference item -
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Selective metal-site-guided arylation of proteins
Published 2016“…We describe a palladium-mediated S-arylation method that exploits natural metal-binding motifs to ensure high site-selectivity for a proximal reactive residue. …”
Journal article -
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A convenient catalyst for aqueous and protein Suzuki-Miyaura cross-coupling.
Published 2009“…A phosphine-free palladium catalyst for aqueous Suzuki-Miyaura cross-coupling is presented. …”
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Design of artificial metalloenzymes for C-C cross-coupling reactions
Published 2014“…A catalytically potent metal catalyst (palladium) was appropriately positioned to carry out oxidative Heck reaction between an alkene and arylboronic acid substrates in the active site of SBL. …”
Thesis -
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Chemical probing of glycogenesis
Published 2018“…This leads to the application of this reaction as part of a novel palladium-mediated enzyme activation process for Glycogenin, allowing unprecedented access to different, homogeneously glucosylated enzyme states. …”
Thesis -
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Novel halogenation and pallado-biology strategies for biological probes
Published 2016“…We subsequently demonstrated novel and efficient palladium-catalysed cross-couplings of the resultant iodinated tyrosine/histidine moieties, leading to the creation of new C-C bonds. …”
Thesis