Epidemiology and burden of multidrug-resistant bacterial infection in a developing country. by Lim, C, Takahashi, E, Hongsuwan, M, Wuthiekanun, V, Thamlikitkul, V, Hinjoy, S, Day, N, Peacock, S, Limmathurotsakul, D

Transmission dynamics and control of multidrug-resistant Klebsiella pneumoniae in neonates in a developing country by Crellen, T, Turner, P, Pol, S, Baker, S, Nguyen Thi Nguyen, T, Stoesser, N, Day, N, Turner, C, Cooper, B

“…Multidrug-resistant Klebsiella pneumoniae is an increasing cause of infant mortality in developing countries. We aimed to develop a quantitative understanding of the drivers of this epidemic by estimating the effects of antibiotics on nosocomial transmission risk, comparing competing hypotheses about mechanisms of spread, and quantifying the impact of potential interventions. …”

Factors predicting and reducing mortality in patients with invasive Staphylococcus aureus disease in a developing country. by Nickerson, E, Wuthiekanun, V, Wongsuvan, G, Limmathurosakul, D, Srisamang, P, Mahavanakul, W, Thaipadungpanit, J, Shah, K, Arayawichanont, A, Amornchai, P, Thanwisai, A, Day, N, Peacock, S

“…The range of clinical manifestations was broad and comparable to that described in developed countries. All-cause and S. aureus-attributable mortality rates were 26% and 20%, respectively. …”

Clinical Epidemiology of 7,126 Melioidosis Patients in Thailand and the Implications for a National Notifiable Diseases Surveillance System by Hantrakun, V, Kongyu, S, Klaytong, P, Rongsumlee, S, Day, N, Peacock, S, Hinjoy, S, Limmathurotsakul, D

“…<p><strong>Background</strong> National notifiable diseases surveillance system (NNDSS) data in developing countries are usually incomplete, yet the total number of fatal cases reported is commonly used in national priority-setting. …”

MBL genotype and risk of invasive pneumococcal disease: a case-control study. by Roy, S, Knox, K, Segal, S, Griffiths, D, Moore, C, Welsh, K, Smarason, A, Day, N, McPheat, W, Crook, D, Hill, A

“… BACKGROUND: Streptococcus pneumoniae is a major cause of morbidity and mortality in developed and developing countries. No common genetic determinants of susceptibility have been defined. …”

The treatment of severe malaria. by Dondorp, A, Day, N

“…The increasing availability of basic intensive care facilities in developing countries also has the potential to further reduce mortality.…”

Community engagement on the Thai-Burmese border: rationale, experience and lessons learnt. by Cheah, P, Lwin, K, Phaiphun, L, Maelankiri, L, Parker, M, Day, N, White, N, Nosten, F

“…Community engagement is increasingly promoted in developing countries, especially in international health research, but there is little published experience. …”

Staphylococcus aureus disease and drug resistance in resource-limited countries in south and east Asia. by Nickerson, E, West, T, Day, N, Peacock, S

“…An initiative is needed to raise the profile of S aureus disease in developing countries, and to define a programme of research to find practical solutions to the health-care challenges posed by this important global pathogen.…”

Mortality attributable to seasonal influenza A and B infections in Thailand, 2005-2009 : a longitudinal study by Cooper, B, Kotirum, S, Kulpeng, W, Praditsitthikorn, N, Chittaganpitch, M, Limmathurotsakul, D, Day, N, Coker, R, Teerawattananon, Y, Meeyai, A

“…Influenza epidemiology differs substantially in tropical and temperate zones, but estimates of seasonal influenza mortality in developing countries in the tropics are lacking. We aimed to quantify mortality due to seasonal influenza in Thailand, a tropical middle-income country. …”

Systematic review and consensus guidelines for environmental sampling of Burkholderia pseudomallei. by Limmathurotsakul, D, Dance, D, Wuthiekanun, V, Kaestli, M, Mayo, M, Warner, J, Wagner, D, Tuanyok, A, Wertheim, H, Yoke Cheng, T, Mukhopadhyay, C, Puthucheary, S, Day, N, Steinmetz, I, Currie, B, Peacock, S

“…We developed consensus guidelines with the goals of reducing the probability of false-negative results, and the provision of affordable and 'low-tech' methodology that is applicable in both developed and developing countries. CONCLUSIONS/SIGNIFICANCE: The proposed consensus guidelines provide the basis for the development of an accurate and comprehensive global map of environmental B. pseudomallei.…”

Increasing incidence of hospital-acquired and healthcare-associated bacteremia in northeast Thailand: a multicenter surveillance study by Hongsuwan, M, Srisamang, P, Kanoksil, M, Luangasanatip, N, Jatapai, A, Day, N, Peacock, S, Cooper, B, Limmathurotsakul, D

“…Background Little is known about the epidemiology of nosocomial bloodstream infections in public hospitals in developing countries. We evaluated trends in incidence of hospital-acquired bacteremia (HAB) and healthcare-associated bacteremia (HCAB) and associated mortality in a developing country using routinely available databases. …”

Emergence of community-associated methicillin-resistant Staphylococcus aureus associated with pediatric infection in Cambodia. by Chheng, K, Tarquinio, S, Wuthiekanun, V, Sin, L, Thaipadungpanit, J, Amornchai, P, Chanpheaktra, N, Tumapa, S, Putchhat, H, Day, N, Peacock, S

“… BACKGROUND: The incidence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection is rising in the developed world but appears to be rare in developing countries. One explanation for this difference is that resource poor countries lack the diagnostic microbiology facilities necessary to detect the presence of CA-MRSA carriage and infection. …”

Long-term survival after intensive care unit discharge in Thailand: a retrospective study. by Luangasanatip, N, Hongsuwan, M, Lubell, Y, Limmathurotsakul, D, Teparrukkul, P, Chaowarat, S, Day, N, Graves, N, Cooper, B

“…Further work assessing Health Related Quality of Life (HRQOL) in both post-ICU patients and in the general population in developing countries is needed.…”

Feasibility of modified surviving sepsis campaign guidelines in a resource-restricted setting based on a cohort study of severe S. aureus sepsis [corrected]. by Mahavanakul, W, Nickerson, E, Srisomang, P, Teparrukkul, P, Lorvinitnun, P, Wongyingsinn, M, Chierakul, W, Hongsuwan, M, West, T, Day, N, Limmathurotsakul, D, Peacock, S

“…BACKGROUND: The Surviving Sepsis Campaign (SSC) guidelines describe best practice for the management of severe sepsis and septic shock in developed countries, but most deaths from sepsis occur where healthcare is not sufficiently resourced to implement them. …”

Molecular pathological investigation of the pathophysiology of fatal malaria by Prapansilp, P

“…<p>Malaria remains one of the world's major health problems, especially in developing countries. A better understanding of the pathology and pathophysiology of severe malaria is key to develop new treatments. …”

Evaluation of the phenotypic test and genetic analysis in the detection of glucose-6-phosphate dehydrogenase deficiency. by Nantakomol, D, Paul, R, Palasuwan, A, Day, N, White, N, Imwong, M

“…CONCLUSION: The cytochemical method is a significant predictor of this disease, while FS and MR test are recommended for the detection of severe G6PD deficiency in developing countries.…”

Diagnostic and treatment difficulties of pyelonephritis in pregnancy in resource-limited settings. by Mcgready, R, Wuthiekanun, V, Ashley, E, Tan, S, Pimanpanarak, M, Viladpai-Nguen, S, Jesadapanpong, W, Blacksell, S, Proux, S, Day, N, Singhasivanon, P, White, N, Nosten, F, Peacock, S

“…The rate and causes of pyelonephritis in pregnant refugee and migrant women were comparable with those described in developed countries. Diagnostic innovation in microbiology that permits affordable access is a high priority for resource-poor settings.…”

Oral versus intravenous flucytosine in patients with human immunodeficiency virus-associated cryptococcal meningitis. by Brouwer, A, van Kan, H, Johnson, E, Rajanuwong, A, Teparrukkul, P, Wuthiekanun, V, Chierakul, W, Day, N, Harrison, T

“…The results suggest that either formulation can be used safely at this dosage in a developing country setting, without drug concentration monitoring. …”