Single dose oral ibuprofen for acute postoperative pain in adults. by Derry, C, Derry, S, Moore, R, McQuay, H

“…DATA COLLECTION AND ANALYSIS: Two review authors independently assessed trial quality and extracted data. Pain relief or pain intensity data were extracted and converted into the dichotomous outcome of number of participants with at least 50% pain relief over 4 to 6 hours, from which relative risk and number-needed-to-treat-to-benefit (NNT) were calculated. …”

Sumatriptan (rectal route of administration) for acute migraine attacks in adults. by Derry, C, Derry, S, Moore, R

“…The NNTs for sumatriptan 25 mg versus placebo were 4.2, 3.2, and 2.4 for pain-free at two hours, headache relief at one hour, and headache relief at two hours, respectively.Relief of functional disability was greater with sumatriptan than with placebo, with NNTs of 8.0 and 4.0 for the 12.5 mg and 25 mg doses, respectively. …”

Caffeine as an analgesic adjuvant for acute pain in adults. by Derry, C, Derry, S, Moore, R

“…We sought any validated measure of analgesic efficacy, but particularly the number of participants experiencing at least 50% of the maximum possible pain relief over four to six hours, participants reporting a global evaluation of treatment of very good or excellent, or headache relief after two hours. …”

Single dose oral naproxen and naproxen sodium for acute postoperative pain in adults. by Derry, C, Derry, S, Moore, R, McQuay, H

“…DATA COLLECTION AND ANALYSIS: Two review authors independently assessed trial quality and extracted data. Pain relief or pain intensity data were extracted and converted into the dichotomous outcome of number of participants with at least 50% pain relief over four to six hours, from which relative risk and number-needed-to-treat-to-benefit (NNT) were calculated. …”

Single dose oral naproxen and naproxen sodium for acute postoperative pain in adults by Derry, C, Derry, S, Moore, R, McQuay, H

“…Data collection and analysis: Two review authors independently assessed trial quality and extracted data. Pain relief or pain intensity data were extracted and converted into the dichotomous outcome of number of participants with at least 50% pain relief over four to six hours, from which relative risk and number-needed-to-treat-to-benefit (NNT) were calculated. …”

Single dose oral ibuprofen for acute postoperative pain in adults by Derry, C, Derry, S, Moore, R, McQuay, H, Moore, M

“…Data collection and analysis: Two review authors independently assessed trial quality and extracted data. Pain relief or pain intensity data were extracted and converted into the dichotomous outcome of number of participants with at least 50% pain relief over 4 to 6 hours, from which relative risk and number-needed-to-treat-to-benefit (NNT) were calculated. …”

Sumatriptan (subcutaneous route of administration) for acute migraine attacks in adults. by Derry, C, Derry, S, Moore, R

“…Results for the 4 mg and 8 mg doses were similar to the 6 mg dose, with 6 mg significantly better than 4 mg only for pain-free at one hour, and 8 mg significantly better than 6 mg only for headache relief at one hour. There was no evidence of increased migraine relief if a second dose of sumatriptan 6 mg was given after an inadequate response to the first.Relief of headache-associated symptoms, including nausea, photophobia, and phonophobia, was greater with sumatriptan than with placebo, and use of rescue medication was lower with sumatriptan than placebo. …”

Sumatriptan (oral route of administration) for acute migraine attacks in adults. by Derry, C, Derry, S, Moore, R

“…For sumatriptan 50 mg versus placebo the NNTs were 6.1, 7.5, and 4.0 for pain-free at two hours and headache relief at one and two hours, respectively. NNTs for sustained pain-free and sustained headache relief during the 24 hours postdose were 9.5 and 6.0, respectively. …”

Single dose oral ibuprofen plus oxycodone for acute postoperative pain in adults. by Derry, S, Derry, C, Moore, R

“…We used the area under the pain relief versus time curve to derive the proportion of participants prescribed ibuprofen plus oxycodone, ibuprofen alone, oxycodone alone, or placebo with at least 50% pain relief over six hours, using validated equations. …”

Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain. by Derry, C, Derry, S, Moore, R

“…We used validated equations to calculate the area under the pain relief versus time curve and derive the proportion of participants with at least 50% of maximum pain relief over six hours. …”

Sumatriptan (intranasal route of administration) for acute migraine attacks in adults. by Derry, C, Derry, S, Moore, R

“…For sumatriptan 10 mg versus placebo the NNTs were 7.3, 7.4, and 5.5 for pain-free at two hours, and headache relief at one and two hours, respectively. For sumatriptan 20 mg versus placebo the NNTs were 4.7, 4.9, and 3.5, respectively, for the same outcomes. …”