Responder analysis for pain relief and numbers needed to treat in a meta-analysis of etoricoxib osteoarthritis trials: bridging a gap between clinical trials and clinical practice by Moore, R, Moore, O, Derry, S, Peloso, P, Gammaitoni, A, Wang, H

“…Response rates fell with increasing pain relief: 60-80% experienced minimally important pain relief (≥15%), 50-60% moderate pain relief (≥30%), 40-50% substantial pain relief (≥50%) and 20-30% extensive pain relief (≥70%). …”

Responder analysis for pain relief and numbers needed to treat in a meta-analysis of etoricoxib osteoarthritis trials: bridging a gap between clinical trials and clinical practice. by Moore, R, Moore, O, Derry, S, Peloso, P, Gammaitoni, A, Wang, H

“…Response rates fell with increasing pain relief: 60-80% experienced minimally important pain relief (> or =15%), 50-60% moderate pain relief (> or =30%), 40-50% substantial pain relief (> or =50%) and 20-30% extensive pain relief (> or =70%). …”

Ibuprofen with or without an antiemetic for acute migraine headaches in adults by Rabbie, R, Derry, S, Moore, R

“…We searched Cochrane CENTRAL, MEDLINE, EMBASE and the Oxford Pain Relief Database for studies through 22 April 2010. …”

Ibuprofen with or without an antiemetic for acute migraine headaches in adults. by Rabbie, R, Derry, S, Moore, R, McQuay, H

“…For ibuprofen 400 mg versus placebo, NNTs for 2-hour pain-free (26% versus 12% with placebo), 2-hour headache relief (57% versus 25%) and 24-hour sustained headache relief (45% versus 19%) were 7.2, 3.2 and 4.0, respectively. …”

Single dose dipyrone for acute postoperative pain. by Edwards, J, Meseguer, F, Faura, C, Moore, R, McQuay, H, Derry, S

“…DATA COLLECTION AND ANALYSIS: Studies were assessed for methodological quality and data extracted by two review authors independently. Summed total pain relief over six hours (TOTPAR) was used to calculate the number of participants achieving at least 50% pain relief. …”

Single dose dipyrone for acute postoperative pain. by Edwards, J, Meseguer, F, Faura, C, Moore, R, McQuay, H, Derry, S

“…DATA COLLECTION AND ANALYSIS: Studies were assessed for methodological quality and data extracted by two review authors independently. Summed total pain relief over six hours (TOTPAR) was used to calculate the number of participants achieving at least 50% pain relief. …”

Numbers needed to treat calculated from responder rates give a better indication of efficacy in osteoarthritis trials than mean pain scores. by Moore, R, Moore, O, Derry, S, McQuay, H

“…These different levels of pain relief were used to distinguish different definitions of responders, for example at least 50% pain relief from baseline. …”

Single dose oral paracetamol (acetaminophen) with codeine for postoperative pain in adults. by Toms, L, Derry, S, Moore, R, McQuay, H

“…Combining drugs from different classes with different modes of action may offer opportunity to optimise efficacy and tolerability, using lower doses of each drug to achieve the same degree of pain relief. Previously we concluded that addition of codeine to paracetamol provided additional pain relief, but at expense of additional adverse events. …”

Single dose oral paracetamol (acetaminophen) with codeine for postoperative pain in adults. by Toms, L, Derry, S, Moore, R, McQuay, H

“…Combining drugs from different classes with different modes of action may offer opportunity to optimise efficacy and tolerability, using lower doses of each drug to achieve the same degree of pain relief. Previously we concluded that addition of codeine to paracetamol provided additional pain relief, but at expense of additional adverse events. …”

Numbers needed to treat calculated from responder rates give a better indication of efficacy in osteoarthritis trials than mean pain scores by Moore, R, Moore, O, Derry, S, McQuay, H

“…These different levels of pain relief were used to distinguish different definitions of responders, for example at least 50% pain relief from baseline. …”

Minimum efficacy criteria for comparisons between treatments using individual patient meta-analysis of acute pain trials: examples of etoricoxib, paracetamol, ibuprofen/paracetamol... by Moore, R, Straube, S, Paine, J, Derry, S, McQuay, H

“…Minimum efficacy criteria (MEC) of 0%, or at least 15%, 30%, 50%, and 70% pain relief were used to examine stability over time using total pain relief and summed pain intensity difference (SPID), sex differences, and sensitivity. …”

Single dose oral fenoprofen for acute postoperative pain in adults. by Traa, M, Derry, S, Moore, R

“…We searched Cochrane CENTRAL, MEDLINE, EMBASE and the Oxford Pain Relief Database for studies to December 2010. Single oral dose, randomised, double-blind, placebo-controlled trials of fenoprofen for relief of established moderate to severe postoperative pain in adults. …”

Single dose oral fenoprofen for acute postoperative pain in adults. by Traa, M, Derry, S, Moore, R

“…SEARCH STRATEGY: We searched Cochrane CENTRAL, MEDLINE, EMBASE and the Oxford Pain Relief Database for studies to December 2010. SELECTION CRITERIA: Single oral dose, randomised, double-blind, placebo-controlled trials of fenoprofen for relief of established moderate to severe postoperative pain in adults. …”

Aspirin with or without an antiemetic for acute migraine headaches in adults. by Kirthi, V, Derry, S, Moore, R, McQuay, H

“…SEARCH STRATEGY: We searched Cochrane CENTRAL, MEDLINE, EMBASE and the Oxford Pain Relief Database for studies through 10 March 2010. …”

Intracutaneous or subcutaneous sterile water injection compared with blinded controls for pain management in labour. by Derry, S, Straube, S, Moore, R, Hancock, H, Collins, S

“…BACKGROUND: Intracutaneous or subcutaneous injection of sterile water is rapidly gaining popularity as a method of pain relief in labour and it is therefore essential that it is properly evaluated. …”

Minimum efficacy criteria for comparisons between treatments using individual patient meta-analysis of acute pain trials: examples of etoricoxib, paracetamol, ibuprofen, and ibupro... by Moore, R, Straube, S, Paine, J, Derry, S, McQuay, H

“…Minimum efficacy criteria (MEC) of 0%, or at least 15%, 30%, 50%, and 70% pain relief were used to examine stability over time using total pain relief and summed pain intensity difference (SPID), sex differences, and sensitivity. …”

Nonsteroidal anti-inflammatory drugs, gastroprotection, and benefit-risk. by Moore, R, Derry, S, Simon, L, Emery, P

“…Meta-analyses of NSAID trials in musculoskeletal conditions had bimodal responses with good pain relief or little. Number needed to treat (NNTs) for good pain relief were 3 to 9. …”

Aspirin with or without an antiemetic for acute migraine headaches in adults. by Kirthi, V, Derry, S, Moore, R

“…For all efficacy outcomes, all active treatments were superior to placebo, with NNTs of 8.1, 4.9 and 6.6 for 2-hour pain-free, 2-hour headache relief, and 24-hour headache relief with aspirin alone versus placebo, and 8.8, 3.3 and 6.2 with aspirin plus metoclopramide versus placebo. …”

Aspirin with or without an antiemetic for acute migraine headaches in adults. by Kirthi, V, Derry, S, Moore, R

“…For all efficacy outcomes, all active treatments were superior to placebo, with NNTs of 8.1, 4.9 and 6.6 for 2-hour pain-free, 2-hour headache relief, and 24-hour headache relief with aspirin alone versus placebo, and 8.8, 3.3 and 6.2 with aspirin plus metoclopramide versus placebo. …”

Topical capsaicin for chronic neuropathic pain in adults. by Derry, S, Lloyd, R, Moore, R, McQuay, H

“…Details of definition of pain relief and specific adverse events were sought. MAIN RESULTS: Six studies (389 participants in total) compared regular application of low dose (0.075%) capsaicin cream with placebo cream; the NNT for any pain relief over six to eight weeks was 6.6 (4.1 to 17). …”