Specimens and culture media for the laboratory diagnosis of typhoid fever. by Wain, J, Diep, T, Bay, P, Walsh, A, Vinh, H, Duong, N, Ho, V, Hien, T, Farrar, J, White, N, Parry, C, Day, N

“…Typhi is necessary for the definitive diagnosis of typhoid fever and provides isolates for antibiotic susceptibility testing and epidemiological studies. …”

Use of paired serum samples for serodiagnosis of typhoid fever. by House, D, Chinh, N, Diep, T, Parry, C, Wain, J, Dougan, G, White, N, Hien, T, Farrar, J

“…Using an enzyme-linked immunosorbent assay we demonstrate that, in adult patients with typhoid fever, the sensitivity of a serological test based on the detection of anti-lipopolysaccharide immunoglobulin G is increased when used with paired serum samples taken 1 week apart.…”

Serology of typhoid fever in an area of endemicity and its relevance to diagnosis. by House, D, Wain, J, Ho, V, Diep, T, Chinh, N, Bay, P, Vinh, H, Duc, M, Parry, C, Dougan, G, White, N, Hien, T, Farrar, J

“…These tests could be of use for the diagnosis of typhoid fever in patients who have clinical typhoid fever but are culture negative or in regions where bacterial culturing facilities are not available.…”

Comparative trial of short-course ofloxacin for uncomplicated typhoid fever in Vietnamese children. by Vinh, H, Duong, N, Phuong, LT, Truong, N, Bay, P, Wain, J, Diep, T, Ho, V, White, N, Day, N, Parry, C

“…An open, randomised comparison of 2 or 3 days of oral ofloxacin (10 mg/kg/day) for uncomplicated typhoid fever was conducted in 235 Vietnamese children. …”

Double blind comparison of ibuprofen and paracetamol for adjunctive treatment of uncomplicated typhoid fever. by Vinh, H, Parry, C, Hanh, V, Chinh, M, House, D, Tham, C, Thao, N, Diep, T, Wain, J, Day, N, White, N, Farrar, J

“… BACKGROUND: Antipyretics reduce the prolonged, high fever characteristic of typhoid fever. The benefits of nonsteroidal drugs in this role have not been quantified. …”

Cytokine release by lipopolysaccharide-stimulated whole blood from patients with typhoid fever. by House, D, Chinh, N, Hien, T, Parry, C, Ly, N, Diep, T, Wain, J, Dunstan, S, White, N, Dougan, G, Farrar, J

“…The ex vivo cytokine response to lipopolysaccharide (LPS) of whole blood from patients with typhoid fever was investigated. Tumor necrosis factor (TNF)-alpha release by LPS-stimulated blood was found to be lower during acute typhoid fever than after a course of antimicrobial therapy (P…”

Value of a single-tube widal test in diagnosis of typhoid fever in Vietnam. by Parry, C, Hoa, N, Diep, T, Wain, J, Chinh, N, Vinh, H, Hien, T, White, N, Farrar, J

“…The diagnostic value of an acute-phase single-tube Widal test for suspected typhoid fever was evaluated with 2,000 Vietnamese patients admitted to an infectious disease referral hospital between 1993 and 1998. …”

Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam. by Dunstan, S, Hawn, T, Hue, N, Parry, C, Ho, V, Vinh, H, Diep, T, House, D, Wain, J, Aderem, A, Hien, T, Farrar, J

“…Here we investigated whether TLR5(392STOP) was associated with typhoid fever. The frequency of TLR5(392STOP) was not significantly different in 565 patients with typhoid fever and 281 ethnically matched control subjects. …”

Quantitation of bacteria in blood of typhoid fever patients and relationship between counts and clinical features, transmissibility, and antibiotic resistance. by Wain, J, Diep, T, Ho, V, Walsh, A, Nguyen, T, Parry, C, White, N

Molecular typing of multiple-antibiotic-resistant Salmonella enterica serovar Typhi from Vietnam: application to acute and relapse cases of typhoid fever. by Wain, J, Hien, T, Connerton, P, Ali, T, Parry, C, Chinh, N, Vinh, H, Phuong, C, Ho, V, Diep, T, Farrar, J, White, N, Dougan, G

“…Pulsed-field gel electrophoresis (PFGE) and other typing methods were used to analyze drug-resistant and -susceptible organisms isolated from patients with typhoid fever in several districts in southern Vietnam. …”

Epidemic typhoid in vietnam: molecular typing of multiple-antibiotic-resistant Salmonella enterica serotype typhi from four outbreaks. by Connerton, P, Wain, J, Hien, T, Ali, T, Parry, C, Chinh, N, Vinh, H, Ho, V, Diep, T, Day, N, White, N, Dougan, G, Farrar, J

“…Multidrug-resistant Salmonella enterica serotype Typhi isolates from four outbreaks of typhoid fever in southern Vietnam between 1993 and 1997 were compared. …”

Antibodies to the Vi capsule of Salmonella Typhi in the serum of typhoid patients and healthy control subjects from a typhoid endemic region. by House, D, Ho, V, Diep, T, Chinh, N, Bay, P, Vinh, H, Duc, M, Parry, C, Dougan, G, White, N, Farrar, J, Hien, T, Wain, J

“…Typhi during naturally acquired typhoid fever in an endemic area. METHODOLOGY: An indirect ELISA, using tyraminated, purified Vi-CPS, was used to assay anti-Vi-CPS antibodies from typhoid fever cases and controls living in the Ho Chi Minh City and Mekong Delta region of Viet Nam. …”

Antimicrobial drug resistance of Salmonella enterica serovar typhi in asia and molecular mechanism of reduced susceptibility to the fluoroquinolones. by Chau, T, Campbell, J, Galindo, C, Van Minh Hoang, N, Diep, T, Nga, T, Van Vinh Chau, N, Tuan, P, Page, A, Ochiai, R, Schultsz, C, Wain, J, Bhutta, Z, Parry, C, Bhattacharya, S, Dutta, S, Agtini, M, Dong, B, Honghui, Y, Anh, D, Canh, D, Naheed, A, Albert, M, Phetsouvanh, R, Newton, P

“…The eight Asian countries involved in this study are home to approximately 80% of the world's typhoid fever cases. These results document the scale of drug resistance across Asia. …”