Palladium catalysed allene carbocyclisation by Li, M

“…The method is mild, efficient and broad in scope.</p> <p>A palladium catalysed diastereoselective allene carbocyclisation reaction was developed via enamine catalysis and palladium catalysis, which allows for the efficient carbocyclisation of formyl or ketone allenes. …”

Enantio- and diastereoselective palladium catalysed arylative and vinylative allene carbocyclisation cascades. by Li, M, Hawkins, A, Barber, D, Bultinck, P, Herrebout, W, Dixon, D

Dual amine and palladium catalysis in diastereo- and enantioselective allene carbocyclization reactions. by Li, M, Datta, S, Barber, D, Dixon, D

Stereoselective spirolactam synthesis via palladium catalyzed arylative allene carbocyclization cascades. by Li, M, Dixon, D

An expedient stereoselective route to the ACE tricyclic core of manzamine A via a palladium-catalysed arylative allene spirocyclisation cascade by Hawkins, A, Jakubec, P, Ironmonger, A, Dixon, D

Studies towards the total synthesis of manzamine A by Hawkins, A

“…</p> <p>The first route applied a novel palladium-catalysed arylative allene spirocyclisation cascade to the synthesis of manzamine A (9). …”

Total synthesis of the polyenoyltetramic acid mycotoxin erythroskyrine by Dixon, D, Ley, S, Gracza, T, Szolcsanyi, P

“…The first total synthesis of erythroskyrine, a polyenoyltetramic acid mycotoxin and principal pigment of Pénicillium Islandicum Sopp., is described using a palladium(n) catalysed oxycarbonylation to create the furan-derived bicyclic portion 3 and the phosphonate ester 5 to furnish both the polyenoyl chain and the N-methyl (S)valine derived tetramic acid terminus.…”

The synthesis of mono- and bicyclic ethers via acid catalysed ring-opening cyclisation of tetrahydropyranyl ether derivatives by Dixon, D, Ley, S, Tate, E

“…A range of monocyclic and bicyclic alkenols were synthesised via acid catalysed ring-opening cyclisation of homballylic tetrahydropyranyl ether derivatives in excellent yield. Upon palladium catalysed hydrogenation these products were reduced with excellent diastereoselectivity to the corresponding saturated cyclic alcohols in essentially quantitative yield. © The Royal Society of Chemistry 2000.…”

Enantioselective construction of the ABCDE pentacyclic core of the Strychnos alkaloids by Gammack Yamagata, A, Dixon, D

“…A key feature of this approach is an organocatalyzed enantioselective desymmetrization to generate the morphan core in high ee and dr. After palladium-catalyzed installation of the indole moiety, a subsequent 5-exo-trig dearomatizing atom transfer radical cyclization was developed to construct the C-ring. …”

Total synthesis of manzamine A and related alkaloids. by Jakubec, P, Hawkins, A, Felzmann, W, Dixon, D

“…The route pivoted on the construction of a late-stage protecting-group-free pentacyclic enol triflate coupling partner, from which all three family members were accessed divergently via palladium-catalyzed reactions. The rapid synthesis of this key pentacyclic enol triflate was achieved by a highly convergent union of five fragments through a stereoselective Michael addition, a three-component nitro-Mannich lactamization cascade, an unprecedented and highly stereoselective reductive nitro-Mannich cyclization cascade, a stereoselective organometallic addition, and a Z-selective alkene ring-closing metathesis. …”

Total synthesis of complex natural products by Kučera, R

“…</p> <p><strong>Chapter 2</strong> details the development of the enantioselective synthesis of <em>Daphniphyllum</em> alkaloids based on the previous accomplishments of our research group. The combination of palladium/enamine cocatalysed enantioselective synthesis of the morphan core and Michael addition – ketone allylation – ringclosing metathesis sequence enabled a highly convergent total synthesis of Himalensine A. …”