An evaluation of a rapid serodiagnostic test for typhoid fever - An giang, Vietnam 2005-2006 by Jain, S, Lan, N, Tai, D, Rang, N, La, T, Bird, M, Dolecek, C, Van Sach, N, Bang, B, Mintz, E, Cam, P, Ram, P

Combined high-resolution genotyping and geospatial analysis reveals modes of endemic urban typhoid fever transmission by Baker, S, Holt, K, Clements, A, Karkey, A, Arjyal, A, Boni, M, Dongol, S, Hammond, N, Koirala, S, Duy, P, Nga, T, Campbell, J, Dolecek, C, Basnyat, B, Dougan, G, Farrar, J

Combined high-resolution genotyping and geospatial analysis reveals modes of endemic urban typhoid fever transmission. by Baker, S, Holt, K, Clements, A, Karkey, A, Arjyal, A, Boni, M, Dongol, S, Hammond, N, Koirala, S, Duy, P, Nga, T, Campbell, J, Dolecek, C, Basnyat, B, Dougan, G, Farrar, J

Estimating the effect of vaccination on antimicrobial-resistant typhoid fever in 73 countries supported by Gavi: a mathematical modelling study by Birger, R, Antillón, M, Bilcke, J, Dolecek, C, Dougan, G, Pollard, AJ, Neuzil, KM, Frost, I, Laxminarayan, R, Pitzer, VE

“…<strong>Background<br></strong> Multidrug resistance and fluoroquinolone non-susceptibility (FQNS) are major concerns for the epidemiology and treatment of typhoid fever. The 2018 prequalification of the first typhoid conjugate vaccine (TCV) by WHO provides an opportunity to limit the transmission and burden of antimicrobial-resistant typhoid fever. …”

A Bayesian approach for estimating typhoid fever incidence from large-scale facility-based passive surveillance data by Phillips, MT, Meiring, JE, Voysey, M, Warren, JL, Baker, S, Basnyat, B, Clemens, JD, Dolecek, C, Dunstan, SJ, Dougan, G, Gordon, MA, Thindwa, D, Heyderman, RS, Holt, KE, Qadri, F, Pollard, AJ, Pitzer, VE

“…Decisions about typhoid fever prevention and control are based on estimates of typhoid incidence and their uncertainty. …”

A multi-center randomised controlled trial of gatifloxacin versus azithromycin for the treatment of uncomplicated typhoid fever in children and adults in Vietnam. by Dolecek, C, Tran, T, Nguyen, N, Le, T, Ha, V, Phung, Q, Doan, C, Nguyen, T, Duong, T, Luong, B, Nguyen, T, Nguyen, T, Pham, N, Mai, N, Phan, V, Vo, A, Nguyen, V, Tran, T, Tran, T, Schultsz, C, Dunstan, S, Stepniewska, K, Campbell, J, To, S, Basnyat, B, Nguyen, V, Nguyen, V, Nguyen, T, Tran, T, Farrar, J

“… BACKGROUND: Drug resistant typhoid fever is a major clinical problem globally. Many of the first line antibiotics, including the older generation fluoroquinolones, ciprofloxacin and ofloxacin, are failing. …”

Global diversity and antimicrobial resistance of typhoid fever pathogens: insights from a meta-analysis of 13,000 Salmonella Typhi genomes by Carey, ME, Dyson, ZA, Ingle, DJ, Amir, A, Aworh, MK, Chattaway, MA, Chew, KL, Crump, JA, Feasey, NA, Howden, BP, Keddy, KH, Maes, M, Parry, CM, Van Puyvelde, S, Webb, HE, Afolayan, AO, Alexander, AP, Anandan, S, Andrews, JR, Ashton, PM, Basnyat, B, Bavdekar, A, Bogoch, II, Clemens, JD, da Silva, KE, De, A, de Ligt, J, Diaz Guevara, PL, Dolecek, C, Dutta, S, Ehlers, MM, Francois Watkins, L, Garrett, DO, Godbole, G, Gordon, MA, Greenhill, AR, Griffin, C, Gupta, M, Hendriksen, RS, Heyderman, RS, Hooda, Y, Hormazabal, JC, Ikhimiukor, OO, Iqbal, J, Jacob, JJ, Jenkins, C, Jinka, DR, John, J, Kang, G, Kanteh, A, Pollard, AJ, Argimón, S, Aanensen, DM

Azithromycin and cefixime combination versus azithromycin alone for the out-patient treatment of clinically suspected or confirmed uncomplicated typhoid fever in South Asia: a randomised controlled trial protocol by Giri, A, Karkey, A, Dongol, S, Arjyal, A, Maharjan, A, Veeraraghavan, B, Paudyal, B, Dolecek, C, Gajurel, D, Phuong, DNT, Thanh, DP, Qamar, F, Kang, G, Hien, HV, John, J, Lawson, K, Wolbers, M, Hossain, MS, Sharifuzzaman, M, Luangasanatip, N, Maharjan, N, Olliaro, P, Rupali, P, Shakya, R, Shakoor, S, Rijal, S, Qureshi, S, Baker, S, Joshi, S, Ahmed, T, Darton, T, Bao, TN, Lubell, Y, Kestelyn, E, Thwaites, G, Parry, C, Basnyat, B

“…Patients with suspected uncomplicated typhoid fever will be randomized to one of the two interventions: Arm A: azithromycin 20mg/kg/day oral dose once daily (maximum 1gm/day) and cefixime 20mg/kg/day oral dose in two divided doses (maximum 400mg bd) for 7 days, Arm B: azithromycin 20mg/kg/day oral dose once daily (max 1gm/day) for 7 days AND cefixime-matched placebo for 7 days. …”

The Surveillance for Enteric Fever in Asia Project (SEAP), Severe Typhoid Fever Surveillance in Africa (SETA), Surveillance of Enteric Fever in India (SEFI), and Strategic Typhoid Alliance Across Africa and Asia (STRATAA) Population-based Enteric Fever Studies: a review of methodological similarities and differences by Carey, ME, MacWright, WR, Im, J, Meiring, JE, Gibani, MM, Park, SE, Longley, A, Jeon, HJ, Hemlock, C, Yu, AT, Soura, A, Aiemjoy, K, Owusu-Dabo, E, Terferi, M, Islam, S, Lunguya, O, Jacobs, J, Gordon, M, Dolecek, C, Baker, S, Pitzer, VE, Yousafzai, MT, Tonks, S, Clemens, JD, Date, K, Qadri, F, Heyderman, RS, Saha, SK, Basnyat, B, Okeke, IN, Qamar, FN, Voysey, M, Luby, S, Kang, G, Andrews, J, Pollard, AJ, John, J, Garrett, D, Marks, F

Temporal fluctuation of multidrug resistant salmonella typhi haplotypes in the mekong river delta region of Vietnam. by Holt, K, Dolecek, C, Chau, T, Duy, P, La, T, Hoang, N, Nga, T, Campbell, J, Manh, B, Vinh Chau, N, Hien, T, Farrar, J, Dougan, G, Baker, S

“… BACKGROUND: typhoid fever remains a public health problem in Vietnam, with a significant burden in the Mekong River delta region. …”

Temporal fluctuation of multidrug resistant Salmonella Typhi haplotypes in the Mekong River delta region of Vietnam by Holt, K, Dolecek, C, Chau, T, Duy, P, La, T, Hoang, N, Nga, T, Campbell, J, Manh, B, Chau, N, Hien, T, Farrar, J, Dougan, G, Baker, S

“…<p>Background: Typhoid fever remains a public health problem in Vietnam, with a significant burden in the Mekong River delta region. …”

Transcriptional response in the peripheral blood of patients infected with Salmonella enterica serovar Typhi. by Thompson, L, Dunstan, S, Dolecek, C, Perkins, T, House, D, Dougan, G, Nguyen, T, Tran, T, Doan, C, Le, T, Nguyen, T, Tran, T, Farrar, J, Monack, D, Lynn, D, Popper, S, Falkow, S

“…We used microarrays and transcriptional profiling of peripheral blood to investigate the host response of 29 individuals who contracted typhoid fever in the Mekong Delta region of Vietnam. …”

The microbiological and clinical characteristics of invasive salmonella in gallbladders from cholecystectomy patients in kathmandu, Nepal by Dongol, S, Thompson, C, Clare, S, Nga, T, Duy, P, Karkey, A, Arjyal, A, Koirala, S, Khatri, N, Maskey, P, Poudel, S, Jaiswal, V, Vaidya, S, Dougan, G, Farrar, J, Dolecek, C, Basnyat, B, Baker, S

“…Gallbladder carriage of invasive Salmonella is considered fundamental in sustaining typhoid fever transmission. Bile and tissue was obtained from 1,377 individuals undergoing cholecystectomy in Kathmandu to investigate the prevalence, characteristics and relevance of invasive Salmonella in the gallbladder in an endemic area. …”

A randomised trial evaluating the safety and immunogenicity of the novel single oral dose typhoid vaccine M01ZH09 in healthy Vietnamese children. by Tran, T, Nguyen, T, Nguyen, T, Ninh, T, Tran, N, Nguyen, V, Tran, T, Cao, T, Pham, V, Nguyen, T, Tran, T, Pham, V, To, S, Campbell, J, Stockwell, E, Schultsz, C, Simmons, C, Glover, C, Lam, W, Marques, F, May, J, Upton, A, Budhram, R, Dougan, G, Farrar, J, Nguyen, V, Dolecek, C

“… BACKGROUND: The emergence of drug resistant typhoid fever is a major public health problem, especially in Asia. …”

Estimating the subnational prevalence of antimicrobial resistant Salmonella enterica serovars Typhi and Paratyphi A infections in 75 endemic countries, 1990–2019: a modelling study... by Browne, AJ, Chipeta, MG, Fell, FJ, Haines-Woodhouse, G, Kashef Hamadani, BH, Kumaran, EAP, Robles Aguilar, G, McManigal, B, Ashley, EA, Basnyat, B, Chansamouth, V, Dunachie, SJ, Henry, NJ, Karkey, A, Mayxay, M, Newton, PN, Phommasone, K, Pokharel, S, Pollard, AJ, Roberts, T, Shakya, M, Turner, C, Day, NPJ, Sartorius, B, Dolecek, C

“…Our analysis highlights the increasing levels of AMR in this preventable infection and serves as a resource to guide urgently needed public health interventions, such as improvements in water, sanitation, and hygiene and typhoid fever vaccination campaigns.</p> <p><strong>Funding</strong> Fleming Fund, UK Department of Health and Social Care; Wellcome Trust; and Bill and Melinda Gates Foundation.…”