Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort by Fortner, RT, Sarink, D, Schock, H, Johnson, T, Tjønneland, A, Olsen, A, Overvad, K, Affret, A, His, M, Boutron-Ruault, MC, Boeing, H, Trichopoulou, A, Naska, A, Orfanos, P, Palli, D, Sieri, S, Mattiello, A, Tumino, R, Ricceri, F, Bueno-de-Mesquita, HB, Peeters, PH, Van Gils, CH, Weiderpass, E, Lund, E, Quirós, JR, Agudo, A, Sánchez, MJ, Chirlaque, MD, Ardanaz, E, Dorronsoro, M, Key, T, Khaw, KT, Rinaldi, S, Dossus, L, Gunter, M, Merritt, MA, Riboli, E, Kaaks, R

“…Circulating OPG and breast cancer risk has been examined in only one prior study.A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. …”

Postmenopausal serum sex steroids and risk of hormone receptor-positive and -negative breast cancer: a nested case-control study. by James, R, Lukanova, A, Dossus, L, Becker, S, Rinaldi, S, Tjønneland, A, Olsen, A, Overvad, K, Mesrine, S, Engel, P, Clavel-Chapelon, F, Chang-Claude, J, Vrieling, A, Boeing, H, Schütze, M, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Krogh, V, Panico, S, Tumino, R, Sacerdote, C, Rodríguez, L, Buckland, G

“…In a case-control study nested within the EPIC cohort (European Prospective Investigation into Cancer and Nutrition), estradiol, testosterone, and sex hormone-binding globulin levels were measured in prediagnostic serum samples from postmenopausal women not using hormone replacement therapy at blood donation. …”

Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: A nested case-control study by Kühn, T, Kaaks, R, Becker, S, Eomois, P, Clavel-Chapelon, F, Kvaskoff, M, Dossus, L, Tjønneland, A, Olsen, A, Overvad, K, Chang-Claude, J, Lukanova, A, Buijsse, B, Boeing, H, Trichopoulou, A, Lagiou, P, Bamia, C, Masala, G, Krogh, V, Sacerdote, C, Tumino, R, Mattiello, A, Buckland, G, Sánchez, M, Menéndez, V

Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: a nested case-control study. by Kühn, T, Kaaks, R, Becker, S, Eomois, P, Clavel-Chapelon, F, Kvaskoff, M, Dossus, L, Tjønneland, A, Olsen, A, Overvad, K, Chang-Claude, J, Lukanova, A, Buijsse, B, Boeing, H, Trichopoulou, A, Lagiou, P, Bamia, C, Masala, G, Krogh, V, Sacerdote, C, Tumino, R, Mattiello, A, Buckland, G, Sánchez, M, Menéndez, V

A nested case-control study of metabolically defined body size phenotypes and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) by Murphy, N, Cross, A, Abubakar, M, Jenab, M, Aleksandrova, K, Boutron-Ruault, M, Dossus, L, Racine, A, Kühn, T, Katzke, V, Tjønneland, A, Petersen, K, Overvad, K, Quirós, JR, Jakszyn, P, Molina-Montes, E, Dorronsoro, M, Huerta, J, Barricarte, A, Khaw, K, Wareham, N, Travis, R, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Masala, G, Krogh, V, Tumino, R, Vineis, P, Panico, S, Bueno-de-Mesquita, H, Siersema, P, Peeters, P, Ohlsson, B, Ericson, U, Palmqvist, R, Nyström, H, Weiderpass, E, Skeie, G, Freisling, H, Kong, S, Tsilidis, K, Muller, D, Riboli, E, Gunter, M

“…Whether similarly variable relationships exist for metabolically defined body size phenotypes and colorectal cancer risk is unknown.The association of metabolically defined body size phenotypes with colorectal cancer was investigated in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. …”

Haplotype-based analysis of common variation in the acetyl-coA carboxylase alpha gene and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. by Sinilnikova, O, McKay, J, Tavtigian, S, Canzian, F, DeSilva, D, Biessy, C, Monnier, S, Dossus, L, Boillot, C, Gioia, L, Hughes, D, Jensen, M, Overvad, K, Tjonneland, A, Olsen, A, Clavel-Chapelon, F, Chajès, V, Joulin, V, Linseisen, J, Chang-Claude, J, Boeing, H, Dahm, S, Trichopoulou, A, Trichopoulos, D, Koliva, M

“…We used a comprehensive haplotype analysis to examine the contribution of the ACC-alpha common genetic variation (allele frequency >5%) to breast cancer in a case-control study (1,588 cases/2,600 controls) nested within the European Prospective Investigation into Cancer and Nutrition. …”

Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). by Dossus, L, McKay, J, Canzian, F, Wilkening, S, Rinaldi, S, Biessy, C, Olsen, A, Tjønneland, A, Jakobsen, M, Overvad, K, Clavel-Chapelon, F, Boutron-Ruault, M, Fournier, A, Linseisen, J, Lukanova, A, Boeing, H, Fisher, E, Trichopoulou, A, Georgila, C, Trichopoulos, D, Palli, D, Krogh, V, Tumino, R, Vineis, P, Quirós, JR

“…We conducted a case-control study on 1359 breast cancer cases and 2389 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition, to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with anthropometric measures, circulating insulin growth factor I (IGF-I) and insulin-like growth factor-binding protein 3 and breast cancer risk. …”

Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort by Fortner, RT, Vitonis, AF, Schock, H, Hüsing, A, Johnson, T, Fichorova, RN, Fashemi, T, Yamamoto, HS, Tjønneland, A, Hansen, L, Overvad, K, Boutron-Ruault, M-C, Kvaskoff, M, Severi, G, Boeing, H, Trichopoulou, A, Benetou, V, La Vecchia, C, Palli, D, Sieri, S, Tumino, R, Matullo, G, Mattiello, A, Onland-Moret, NC, Peeters, PH, Weiderpass, E, Gram, IT, Jareid, M, Quirós, JR, Duell, EJ, Sánchez, M-J, Chirlaque, MD, Ardanaz, E, Larrañaga, N, Nodin, B, Brändstedt, J, Idahl, A, Khaw, K-T, Allen, N, Gunter, M, Johansson, M, Dossus, L, Merritt, MA, Riboli, E, Cramer, DW, Kaaks, R, Terry, KL

“…<br/><strong>Methods: </strong>We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). …”

Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort. by Ose, J, Fortner, RT, Schock, H, Peeters, P, Onland-Moret, N, Bueno-de-Mesquita, H, Weiderpass, E, Gram, I, Overvad, K, Tjonneland, A, Dossus, L, Fournier, A, Baglietto, L, Trichopoulou, A, Benetou, V, Trichopoulos, D, Boeing, H, Masala, G, Krogh, V, Matiello, A, Tumino, R, Popovic, M, Obón-Santacana, M, Larrañaga, N, Ardanaz, E

“…METHODS: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). …”

Investigating sources of variability in metabolomic data in the EPIC study: the Principal Component Partial R-square (PC-PR2) method by Fages, A, Ferrari, P, Monni, S, Dossus, L, Floegel, A, Mode, N, Johansson, M, Travis, R, Bamia, C, Sanchez-Perez, M, Chiodini, P, Boshuizen, H, Chadeau-Hyam, M, Riboli, E, Jenab, M, Elena-Herrmann, B

“…Within the European Prospective Investigation into Cancer and nutrition (EPIC), metabolic profiles were determined by 1H NMR analysis on 807 serum samples originating from a nested liver cancer case-control study. PC-PR2 was used to quantify the variability of metabolomic profiles in terms of study subjects age, sex, body mass index, country of origin, smoking status, diabetes and fasting status, as well as factors related to sample processing. …”

Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) coh... by Duell, E, Travier, N, Lujan-Barroso, L, Dossus, L, Boutron-Ruault, M, Clavel-Chapelon, F, Tumino, R, Masala, G, Krogh, V, Panico, S, Ricceri, F, Redondo, M, Dorronsoro, M, Molina-Montes, E, Huerta, J, Barricarte, A, Khaw, K, Wareham, N, Allen, N, Travis, R, Siersema, P, Peeters, P, Trichopoulou, A, Fragogeorgi, E, Oikonomou, E

“…Then, in a case-control study nested within the EPIC cohort, we examined 12 single nucleotide polymorphisms (SNPs) in CYP17A1 (an essential gene in sex steroid metabolism) for association with pancreatic cancer in women and men (324 cases and 353 controls). …”

Physical activity, sex steroid, and growth factor concentrations in pre- and post-menopausal women: A cross-sectional study within the EPIC cohort by Rinaldi, S, Kaaks, R, Friedenreich, C, Key, T, Travis, R, Biessy, C, Slimani, N, Overvad, K, Østergaard, J, Tjønneland, A, Olsen, A, Mesrine, S, Fournier, A, Dossus, L, Lukanova, A, Johnson, T, Boeing, H, Vigl, M, Trichopoulou, A, Benetou, V, Trichopoulos, D, Masala, G, Krogh, V, Tumino, R, Ricceri, F

“…Methods: A cross-sectional analysis of 798 pre- and 1,360 post-menopausal women included as controls in case-control studies on endogenous hormones (steroids, progesterone, sex-hormone-binding globulin (SHBG), and growth factors) levels, and cancer risk nested within European Prospective Investigation into Cancer and Nutrition cohort was performed. …”

Androgens are differentially associated with ovarian cancer subtypes in the Ovarian Cancer Cohort Consortium by Ose, J, Poole, E, Schock, H, Lehtinen, M, Arslan, A, Zeleniuch-Jacquotte, A, Visvanathan, K, Helzlsouer, K, Buring, J, Lee, I, Tjønneland, A, Dossus, L, Trichopoulou, A, Masala, G, Onland-Moret, N, Weiderpass, E, Duell, E, Idahl, A, Travis, R, Rinaldi, S, Merritt, M, Trabert, B, Wentzensen, N, Tworoger, S, Kaaks, R, Fortner, R

“…We conducted a pooled analysis of 7 nested case-control studies in the Ovarian Cancer Cohort Consortium to investigate the association between pre-diagnosis circulating androgens (testosterone, free testosterone, androstenedione, dehydroepiandrosterone sulfate (DHEAS)), sex hormone binding globulin (SHBG), and EOC risk by tumor characteristics (i.e. histology, grade, and stage). …”

Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC... by Canzian, F, McKay, J, Cleveland, R, Dossus, L, Biessy, C, Rinaldi, S, Landi, S, Boillot, C, Monnier, S, Chajès, V, Clavel-Chapelon, F, Téhard, B, Chang-Claude, J, Linseisen, J, Lahmann, P, Pischon, T, Trichopoulos, D, Trichopoulou, A, Zilis, D, Palli, D, Tumino, R, Vineis, P, Berrino, F, Bueno-de-Mesquita, H, Gils, v

“…We tested this hypothesis with a case-control study of 807 breast cancer patients and 1588 matched control subjects, nested within the European Prospective Investigation into Cancer and Nutrition. …”

Insulin-like growth factor-i and risk of differentiated thyroid carcinoma in the European prospective investigation into cancer and nutrition. by Schmidt, J, Allen, N, Almquist, M, Franceschi, S, Rinaldi, S, Tipper, S, Tsilidis, K, Weiderpass, E, Overvad, K, Tjønneland, A, Boutron-Ruault, M, Dossus, L, Mesrine, S, Kaaks, R, Lukanova, A, Boeing, H, Lagiou, P, Trichopoulos, D, Trichopoulou, A, Palli, D, Krogh, V, Panico, S, Tumino, R, Zanetti, R, Bueno-de-Mesquita, H

“…METHODS: This study prospectively investigated the association between serum IGF-I concentrations and risk of differentiated thyroid carcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. …”

Endometrial cancer risk prediction including serum-based biomarkers: Results from the EPIC cohort by Fortner, R, Hüsing, A, Kühn, T, Konar, M, Overvad, K, Tjønneland, A, Hansen, L, Boutron-Ruault, M, Severi, G, Fournier, A, Boeing, H, Trichopoulou, A, Benetou, V, Orfanos, P, Masala, G, Agnoli, C, Mattiello, A, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, H, Peeters, P, Weiderpass, E, Gram, I, Gavrilyuk, O, Quirós, J, Huerta, J, Ardanaz, E, Larrañaga, N, Lujan-Barroso, L, Sánchez-Cantalejo, E, Butt, S, Borgquist, S, Idahl, A, Lundin, E, Khaw, K, Allen, N, Rinaldi, S, Dossus, L, Gunter, M, Merritt, M, Tzoulaki, I, Riboli, E, Kaaks, R

“…Adding biomarker data to these models may improve predictive capacity; to our knowledge, this has not been investigated for endometrial cancer. Using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we investigated the improvement in discrimination gained by adding serum biomarker concentrations to risk estimates derived from an existing risk prediction model based on epidemiologic factors. …”

Concentrations of IGF-I and IGFBP-3 and brain tumor risk in the European Prospective Investigation into Cancer and Nutrition. by Rohrmann, S, Linseisen, J, Becker, S, Allen, N, Schlehofer, B, Overvad, K, Olsen, A, Tjønneland, A, Melin, B, Lund, E, Vineis, P, Grioni, S, Tumino, R, Palli, D, Mattiello, A, Bonet, C, Chirlaque, MD, Sánchez, M, Rodríguez, L, Dorronsoro, M, Ardanaz, E, Lagiou, P, Trichopoulou, A, Trichopoulos, D, Dossus, L

“…METHODS: We examined the association between circulating concentrations of IGF-I and IGFBP-3 in relation to risk of gliomas (74 low-grade, 206 high-grade gliomas), meningiomas (n = 174) and acoustic neuromas (n = 49) by using a case-control design nested in the European Prospective Investigation into Cancer and Nutrition. …”

Endogenous androgens and risk of epithelial invasive ovarian cancer by tumor characteristics in the European Prospective Investigation into Cancer and Nutrition. by Ose, J, Fortner, RT, Rinaldi, S, Schock, H, Overvad, K, Tjonneland, A, Hansen, L, Dossus, L, Fournier, A, Baglietto, L, Romieu, I, Kuhn, E, Boeing, H, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Masala, G, Sieri, S, Tumino, R, Sacerdote, C, Mattiello, A, Ramon Quiros, J, Obón-Santacana, M, Larrañaga, N

“…Epithelial invasive ovarian cancer (EOC) is a heterogeneous disease and there are no prospective data on endogenous androgens and EOC risk by tumor characteristics (histology, grade, stage) or the dualistic model of ovarian carcinogenesis (i.e. type I vs. type II, leading to less or more aggressive tumors). We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort evaluating androgens and SHBG and invasive EOC risk by tumor characteristics. …”

Physical activity, sex steroid, and growth factor concentrations in pre- and post-menopausal women: a cross-sectional study within the EPIC cohort. by Rinaldi, S, Kaaks, R, Friedenreich, C, Key, T, Travis, R, Biessy, C, Slimani, N, Overvad, K, Østergaard, J, Tjønneland, A, Olsen, A, Mesrine, S, Fournier, A, Dossus, L, Lukanova, A, Johnson, T, Boeing, H, Vigl, M, Trichopoulou, A, Benetou, V, Trichopoulos, D, Masala, G, Krogh, V, Tumino, R, Ricceri, F

“…METHODS: A cross-sectional analysis of 798 pre- and 1,360 post-menopausal women included as controls in case-control studies on endogenous hormones (steroids, progesterone, sex-hormone-binding globulin (SHBG), and growth factors) levels, and cancer risk nested within European Prospective Investigation into Cancer and Nutrition cohort was performed. …”

The association of circulating adiponectin levels with pancreatic cancer risk: a study within the prospective EPIC cohort. by Grote, V, Rohrmann, S, Dossus, L, Nieters, A, Halkjaer, J, Tjønneland, A, Overvad, K, Stegger, J, Chabbert-Buffet, N, Boutron-Ruault, M, Clavel-Chapelon, F, Teucher, B, Becker, S, Montonen, J, Boeing, H, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Sieri, S, Tumino, R, Vineis, P, Mattiello, A, Argüelles, M, Duell, E

“…We conducted a case-control study nested within European Prospective Investigation into Cancer and Nutrition. …”