Toll-like receptor 4 (TLR4) and typhoid fever in Vietnam. by Nguyen, T, Mai, N, Le, T, Ha, V, Nguyen, T, Tran, T, Nguyen, T, Farrar, J, Dunstan, S

“…Understanding the host genetic susceptibility to typhoid fever may provide a better understanding of pathogenesis and help in the development of new therapeutics and vaccines. …”

Toll-like receptor 4 (TLR4) and typhoid fever in Vietnam by Nguyen, T, Mai, N, Le, T, Ha, V, Nguyen, T, Tran, T, Nguyen, T, Farrar, J, Dunstan, S

“…Understanding the host genetic susceptibility to typhoid fever may provide a better understanding of pathogenesis and help in the development of new therapeutics and vaccines. …”

Toll-like receptor 4 (TLR4) and typhoid fever in Vietnam by Hue, N, Lanh, M, Phuong, L, Vinh, H, Chinh, N, Hien, T, Hieu, N, Farrar, J, Dunstan, S

“…Understanding the host genetic susceptibility to typhoid fever may provide a better understanding of pathogenesis and help in the development of new therapeutics and vaccines. …”

Cytokine release by lipopolysaccharide-stimulated whole blood from patients with typhoid fever. by House, D, Chinh, N, Hien, T, Parry, C, Ly, N, Diep, T, Wain, J, Dunstan, S, White, N, Dougan, G, Farrar, J

“…The ex vivo cytokine response to lipopolysaccharide (LPS) of whole blood from patients with typhoid fever was investigated. Tumor necrosis factor (TNF)-alpha release by LPS-stimulated blood was found to be lower during acute typhoid fever than after a course of antimicrobial therapy (P…”

Typhoid fever and genetic polymorphisms at the natural resistance-associated macrophage protein 1. by Dunstan, S, Ho, V, Duc, C, Lanh, M, Phuong, C, Luxemburger, C, Wain, J, Dudbridge, F, Peacock, C, House, D, Parry, C, Hien, T, Dougan, G, Farrar, J, Blackwell, J

“…Control of Salmonella enterica serovar Typhimurium (S. typhimurium) infection in the mouse model of typhoid fever is critically dependent on the natural resistance-associated macrophage protein 1 (Nramp1). …”

A TNF region haplotype offers protection from typhoid fever in Vietnamese patients. by Dunstan, S, Nguyen, T, Rockett, K, Forton, J, Morris, A, Diakite, M, Mai, N, Le, T, House, D, Parry, C, Ha, V, Nguyen, T, Dougan, G, Tran, T, Kwiatowski, D, Farrar, J

“…The genomic region surrounding the TNF locus on human chromosome 6 has previously been associated with typhoid fever in Vietnam (Dunstan et al. in J Infect Dis 183:261-268, 2001). …”

Genes of the class II and class III major histocompatibility complex are associated with typhoid fever in Vietnam. by Dunstan, S, Stephens, H, Blackwell, J, Duc, C, Lanh, M, Dudbridge, F, Phuong, C, Luxemburger, C, Wain, J, Ho, V, Hien, T, Farrar, J, Dougan, G

“…The influence of genes of the major histocompatibility complex (MHC) class II and class III loci on typhoid fever susceptibility was investigated. Individuals with blood culture-confirmed typhoid fever and control subjects from 2 distinct geographic locations in southern Vietnam were genotyped for HLA-DRB1 and HLA-DQB1 alleles, the gene that encodes tumor necrosis factor (TNF)-alpha (TNFA [-238] and TNFA [-308]), the gene that encodes lymphotoxin-alpha, and alleles of the TNF-alpha microsatellite. …”

Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam. by Dunstan, S, Hawn, T, Hue, N, Parry, C, Ho, V, Vinh, H, Diep, T, House, D, Wain, J, Aderem, A, Hien, T, Farrar, J

“…Here we investigated whether TLR5(392STOP) was associated with typhoid fever. The frequency of TLR5(392STOP) was not significantly different in 565 patients with typhoid fever and 281 ethnically matched control subjects. …”

Human Chromosome 17q11.2-q22 Contains Typhoid Fever Susceptibility Genes by Nguyen, H, Jamieson, SE, Lanh, M, Phuong, LT, Chinh, N, Hien, T, Blackwell, J, Farrar, J, Dunstan, S

A multi-center randomised controlled trial of gatifloxacin versus azithromycin for the treatment of uncomplicated typhoid fever in children and adults in Vietnam. by Dolecek, C, Tran, T, Nguyen, N, Le, T, Ha, V, Phung, Q, Doan, C, Nguyen, T, Duong, T, Luong, B, Nguyen, T, Nguyen, T, Pham, N, Mai, N, Phan, V, Vo, A, Nguyen, V, Tran, T, Tran, T, Schultsz, C, Dunstan, S, Stepniewska, K, Campbell, J, To, S, Basnyat, B, Nguyen, V, Nguyen, V, Nguyen, T, Tran, T, Farrar, J

“… BACKGROUND: Drug resistant typhoid fever is a major clinical problem globally. Many of the first line antibiotics, including the older generation fluoroquinolones, ciprofloxacin and ofloxacin, are failing. …”

Transcriptional response in the peripheral blood of patients infected with Salmonella enterica serovar Typhi. by Thompson, L, Dunstan, S, Dolecek, C, Perkins, T, House, D, Dougan, G, Nguyen, T, Tran, T, Doan, C, Le, T, Nguyen, T, Tran, T, Farrar, J, Monack, D, Lynn, D, Popper, S, Falkow, S

“…We used microarrays and transcriptional profiling of peripheral blood to investigate the host response of 29 individuals who contracted typhoid fever in the Mekong Delta region of Vietnam. …”

Immune profiling with a Salmonella Typhi antigen microarray identifies new diagnostic biomarkers of human typhoid by Liang, L, Juarez, S, Nga, T, Dunstan, S, Nakajima-Sasaki, R, Davies, D, McSorley, S, Baker, S, Felgner, P

“…Current serological diagnostic assays for typhoid fever are based on detecting antibodies against Salmonella LPS or flagellum, resulting in a high false-positive rate. …”