Thalamic neurodegeneration in multiple sclerosis. by Cifelli, A, Arridge, M, Jezzard, P, Esiri, M, Palace, J, Matthews, P

Neurodegeneration in a marmoset model of multiple sclerosis by Pomeroy, I, Jordan, E, Frank, J, Matthews, P, Esiri, M

The interplay between inflammation and neurodegeneration in CNS disease. by Esiri, M

“…This review considers the manner in which inflammation in the CNS contributes to, and protects against, neurodegeneration. A series of questions are posed, first about primarily inflammatory diseases and the causes of neurodegeneration that occurs in them, and then about neurodegenerative diseases and stroke and the role that inflammation plays there. …”

Fibrin(ogen) and neurodegeneration in the progressive multiple sclerosis cortex by Yates, R, Esiri, M, Palace, J, Jacobs, B, Perera, R, De Luca, G

“…The aim of this study was to investigate the extent and distribution of fibrin(ogen) in progressive MS cortex and elucidate its relationship with neurodegeneration. METHODS: A post-mortem cohort of pathologically confirmed MS (n=47) and control (n=10) cases was used. …”

Concurrent multiple sclerosis and amyotrophic lateral sclerosis: where inflammation and neurodegeneration meet? by Li, G, Esiri, M, Ansorge, O, DeLuca, G

“…The intricate relationship between neuroinflammation and neurodegeneration in these diseases is discussed.…”

Age-related small vessel disease: A potential contributor to neurodegeneration in multiple sclerosis by Geraldes, R, Esiri, M, DeLuca, G, Palace, J

“…Several lines of evidence suggest that an interaction between MS and SVD may influence MS-related neurodegeneration. SVD may contribute to hypoperfusion, reduced vascular reactivity and tissue hypoxia, features seen in MS. …”

A combined post-mortem magnetic resonance imaging and quantitative histological study of multiple sclerosis pathology. by Kolasinski, J, Stagg, C, Chance, SA, Deluca, G, Esiri, M, Chang, E, Palace, J, McNab, J, Jenkinson, M, Miller, K, Johansen-Berg, H

“…One hypothesis is that anatomical connectivity influences the spread of neurodegeneration. This predicts that measures of neurodegeneration will correlate most strongly between interconnected structures. …”

A combined post-mortem magnetic resonance imaging and quantitative histological study of multiple sclerosis pathology by Kolasinski, J, Stagg, C, Chance, S, DeLuca, G, Esiri, M, Chang, E, Palace, J, McNab, J, Jenkinson, M, Miller, K, Johansen-Berg, H

“…One hypothesis is that anatomical connectivity influences the spread of neurodegeneration. This predicts that measures of neurodegeneration will correlate most strongly between interconnected structures. …”

Focal and diffuse cortical degenerative changes in a marmoset model of multiple sclerosis. by Pomeroy, I, Jordan, E, Frank, J, Matthews, P, Esiri, M

“…BACKGROUND: Degenerative features, such as neuronal, glial, synaptic and axonal loss, have been identified in neocortical and other grey matter structures in patients with multiple sclerosis, but mechanisms for neurodegeneration are unclear. Cortical demyelinating lesions are a potential cause of this degeneration, but the pathological and clinical significance of these lesions is uncertain as they remain difficult to identify and study in vivo. …”

Haplotype-specific expression of exon 10 at the human MAPT locus by Caffrey, T, Joachim, C, Paracchini, S, Esiri, M, Wade-Martins, R

“…These data may explain the increased susceptibility of H1 carriers to neurodegeneration and suggest a potential mechanism between MAPT genetic variability and the pathogenesis of neurodegenerative disease.…”

Haplotype-specific expression of exon 10 at the human MAPT locus. by Caffrey, T, Joachim, C, Paracchini, S, Esiri, M, Wade-Martins, R

“…These data may explain the increased susceptibility of H1 carriers to neurodegeneration and suggest a potential mechanism between MAPT genetic variability and the pathogenesis of neurodegenerative disease.…”

The pathology of multiple sclerosis and related disorders by Moore, G, Esiri, M

“…The current concept that MS is an autoimmune disease of myelin has been challenged by recent studies, and it is becoming increasingly clear that neurodegeneration is a significant component of the disease and may largely account for its progressive disability. …”

The effects of two polymorphisms on p21cip1 function and their association with Alzheimer's disease in a population of European descent by Yates, S, Zafar, A, Rabai, E, Foxall, J, Nagy, S, Morrison, K, Clarke, C, Esiri, M, Christie, S, Smith, A, Nagy, Z

“…The results suggest that the cancer-associated variant of p21cip1 may contribute to the loss of cell cycle control in neurons that may lead to Alzheimer-type neurodegeneration.…”

Neuropathology of the hippocampus in FTLD-Tau with Pick bodies: a study of the BrainNet Europe Consortium. by Kovacs, G, Rozemuller, A, van Swieten, J, Gelpi, E, Majtenyi, K, Al-Sarraj, S, Troakes, C, Bódi, I, King, A, Hortobágyi, T, Esiri, M, Ansorge, O, Giaccone, G, Ferrer, I, Arzberger, T, Bogdanovic, N, Nilsson, T, Leisser, I, Alafuzoff, I, Ironside, J, Kretzschmar, H, Budka, H

“…In view of confusion about the molecular pathology of Pick's disease, we aimed to evaluate the spectrum of tau pathology and concomitant neurodegeneration-associated protein depositions in the characteristically affected hippocampus. …”