Downregulation of IFNG in CD4(+) T cells in lung cancer through hypermethylation: a possible mechanism of tumor-induced immunosuppression. by Fang Wang, Jian Xu, Quan Zhu, Xuejun Qin, Yan Cao, Jiangfang Lou, Yuqiao Xu, Xing Ke, Qing Li, Erfu Xie, Lixia Zhang, Ruihong Sun, Liang Chen, Bingliang Fang, Shiyang Pan

“…Our study suggests that interaction between lung cancer cells and CD4(+) T cells induces DNMT expression and IFNG promoter hypermethylation in CD4(+) T cell, which may serve as an important mechanism of tumor-induced immunosuppression.…”
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Distribution and functions of γδ T cells infiltrated in the ovarian cancer microenvironment by Xian Chen, Wenwen Shang, Rui Xu, Ming Wu, Xiaojie Zhang, Peijun Huang, Fang Wang, Shiyang Pan

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New findings on CD16brightCD62Ldim neutrophil subtypes in sepsis-associated ARDS: an observational clinical study by Jing Zhang, Jing Zhang, Chencheng Gao, Zhenxing Zhu, Danyang Li, Lai Qu, Qiuli Xue, Guoqiang Wang, Tong Ji, Fang Wang

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Metabonomics reveals that entomopathogenic nematodes mediate tryptophan metabolites that kill host insects by Yuan Zhang, Fang Wang, Zihua Zhao

“…EPN infection 9 h later led to immunosuppression by activating insect esterase activity, but eventually, the host insect darkened and died. …”
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Clustering and machine learning-based integration identify cancer associated fibroblasts genes’ signature in head and neck squamous cell carcinoma by Qiwei Wang, Yinan Zhao, Fang Wang, Guolin Tan

“…Compared to the low CafS group, the high CafS group was associated with significant immunosuppression, poor prognosis, and increased prospect of HPV negative. …”
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Glucose metabolism and function of CD4+ Tregs are regulated by the TLR8/mTOR signal in an environment of SKOV3 cell growth by Ming Wu, Xin Fu, Rui Xu, Shuna Liu, Rong Li, Juan Xu, Wenwen Shang, Xian Chen, Ting Wang, Fang Wang

“…Simultaneous inhibition of the mTOR signal while activation of the TLR8 signal had a coordinated inhibitory effect on glucose metabolism and the immunosuppressive function of CD4+ Tregs. Furthermore, the mTOR signal played an essential role in TLR8‐mediated reversal of immunosuppressive function in CD4+ Tregs. …”
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Circulating CD4⁺ Treg, CD8⁺ Treg, and CD3⁺ γδ T Cell Subpopulations in Ovarian Cancer by Rong Li, Juan Xu, Ming Wu, Shuna Liu, Xin Fu, Wenwen Shang, Ting Wang, Xuemei Jia, Fang Wang

“…<i>Background and Objectives</i>: Regulatory T cells (Tregs) are usually enriched in ovarian cancer (OC), and their immunosuppressive function plays a key role in tumorigenesis and progression. …”
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CD4+CCR8+ Tregs in ovarian cancer: a potential effector Tregs for immune regulation by Shuna Liu, Ziqi Tao, Jianfang Lou, Rong Li, Xin Fu, Juan Xu, Ting Wang, Lei Zhang, Wenwen Shang, Yepeng Mao, Fang Wang

“…Abstract Background Tregs are key drivers of immunosuppression in solid tumors. As an important chemokine receptor on Tregs, the regulatory effect of CCR8 on tumor immunity has received more and more attention. …”
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Integrated analysis of genome-wide DNA methylation and cancer-associated fibroblasts identified prognostic biomarkers and immune checkpoint blockade in lower grade gliomas by Jiawei Dong, Jiawei Dong, Fang Wang, Fang Wang, Xin Gao, Hongtao Zhao, Hongtao Zhao, Jiheng Zhang, Jiheng Zhang, Nan Wang, Nan Wang, Zhihui Liu, Zhihui Liu, Xiuwei Yan, Xiuwei Yan, Jiaqi Jin, Jiaqi Jin, Yixu Ba, Yixu Ba, Shuai Ma, Shuai Ma, Jianyang Du, Hang Ji, Hang Ji, Shaoshan Hu, Shaoshan Hu

“…BackgroundCancer-associated fibroblasts (CAFs) are vital components of prominent cellular components in lower-grade gliomas (LGGs) that contribute to LGGs’ progression, treatment resistance, and immunosuppression. Epigenetic modification and immunity have significant implications for tumorigenesis and development.MethodsWe combined aberrant methylation and CAFs abundances to build a prognostic model and the impact on the biological properties of LGGs. …”
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Immune modulatory roles of radioimmunotherapy: biological principles and clinical prospects by Xuefeng Wang, Yu Wang, Yonggang Zhang, Hongyun Shi, Kuan Liu, Fang Wang, Yue Wang, Huijing Chen, Yan Shi, Ruiyao Wang

“…On the other hand, RT stimulates tumor cells to express immunosuppressive cytokines, upregulates the function of inhibitory immune cells, leads to lymphocytopenia and depletion of immune effector cells, and thus negatively suppresses immune responses. …”
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Dissecting Heterogeneity Reveals a Unique BAMBIhighMFGE8high Subpopulation of Human UC‐MSCs by Hongwei Chen, Xin Wen, Shanshan Liu, Tian Sun, Hua Song, Fang Wang, Jiayue Xu, Yueyang Zhang, Yuanjin Zhao, Jia Yu, Lingyun Sun

“…Surprisingly, further experimental assays reveal that the BAMBIhighMFGE8high C1 subgroup has a unique phenotype, distinct transcriptomic profile, and limited adipogenic differentiation potential but compromised immunosuppressive activity in vitro and in vivo in lupus mice. …”
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Successful treatment of a refractory intestinal Behcet’s disease with an oncology history by Vedolizumab: a case report and literature review by Ruixia Li, Xiaofei Li, He Zhou, Yanting Shi, Fang Wang, Tong Wu, Jie Liang

“…When accompanied by intestinal symptoms, the prognosis is usually poor. 5-Aminosalicylic acid (5-ASA), corticosteroids, immunosuppressive drugs, and anti-tumor necrosis factor-α (anti-TNF-α) biologics are standard therapies to induce or maintain remission for intestinal BD. …”
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Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis by Chuan Yang, Xueping Wang, Kenneth K. W. To, Caimei Cui, Min Luo, Shaocong Wu, Lamei Huang, Kai Fu, Can Pan, Zeyu Liu, Teng Fan, Caibo Yang, Fang Wang, Liwu Fu

“…Moreover, CD45+ tumor cells orchestrated an immunosuppressive milieu and CD45+ CTCs exhibited remarkably stronger metastatic potential than CD45− CTCs in vivo. …”
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Altered Expression of Signaling Genes in Jurkat Cells upon FTY720 Induced Apoptosis by Shaoheng He, Xiaomin Zhu, Keqing Qian, Dunming Guo, Wenfeng Tan, Fang Wang

“…FTY720, a novel immunosuppressant, has a marked activity in decreasing peripheral blood T lymphocytes upon oral administration. …”
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Activated B cells suppress T-cell function through metabolic competition by Li Li, Michael Green, Fang Wang, Ye Li, Jennifer Wargo, Marina Konopleva, Elizabeth J Shpall, Rafet Basar, May Daher, Ana Karen Nunez Cortes, Hila Shaim, Natalia Baran, Ken Chen, Luis Muniz-Feliciano, Nobuhiko Imahashi, Yuefan Huang, Pinaki Prosad Banerjee, Junjun Lu, Nadima Uprety, Emily Ensley, Tamara J Laskowski, Judy S Moyes, Mayela Mendt, Lucila N Kerbauy, Mayra Shanley, Francesca Lorraine Wei Inng Lim, Katayoun Rezvani

“…The induction of B cell-mediated immunosuppressive function requires B cell activating signals. …”
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Sema4D silencing increases the sensitivity of nivolumab to B16-F10 resistant melanoma via inhibiting the PI3K/AKT signaling pathway by Zhuo Zhang, Duoli Zhang, Fang Wang, Jiao Liu, Yuhong Sun, Songyot Anuchapreeda, Singkome Tima, Zhangang Xiao, Suwit Duangmano

“…Melanoma is a common skin tumor that causes a high rate of mortality, especially in Europe, North America and Oceania. Immunosuppressants such as anti-PD-1 have been used in the treatment of malignant melanoma, however, nearly 60% of patients do not respond to these treatments. …”
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The role of thymus- and extrathymus-derived regulatory T cells in maternal-fetal tolerance by Zhengjuan Li, Xinyuan Liang, Xiaowen Chen, Yuying Chen, Fang Wang, Shuoshi Wang, Yihong Liao, Liping Li

“…In conclusion, increased blood and decidua Treg cells in pregnancy and increased ERRs in DT-treated Foxp3DTR mice suggest an important immunosuppressive role of Treg cells in pregnancy. Elevated decidua Treg cells in pregnancy could be derived from the recruitment of tTreg cells to the decidua, or from the transformation of naïve T cells in the decidua to pTreg cells. …”
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Glycolysis in Innate Immune Cells Contributes to Autoimmunity by Yue Xu, Yongkang Chen, Xuan Zhang, Jie Ma, Yudong Liu, Liyan Cui, Fang Wang

“…Most of the current treatments for AIDs use non-selective immunosuppressive agents. Although these therapies successfully control the disease process, patients experience significant side effects, particularly an increased risk of infection. …”
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A Model of Basement Membrane-Associated Gene Signature Predicts Liver Hepatocellular Carcinoma Response to Immune Checkpoint Inhibitors by Jiajia Shen, Zhihong Wei, Lizhi Lv, Jingxiong He, Suming Du, Fang Wang, Ye Wang, Lin Ni, Xiaojin Zhang, Fan Pan

“…In addition, we analyzed the correlation between the risk score and the tumor immune microenvironment (TIM), and the results showed that the high-risk scoring group tended to be in an immunosuppressed status. Finally, we investigated the relationship between the risk score and LIHC immune function. …”
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Machine learning-based screening of an epithelial-mesenchymal transition-related long non-coding RNA signature reveals lower-grade glioma prognosis and the tumor microenvironment a... by Nan Wang, Nan Wang, Xin Gao, Hang Ji, Shuai Ma, Jiasheng Wu, Jiawei Dong, Fang Wang, Hongtao Zhao, Zhihui Liu, Xiuwei Yan, Bo Li, Jianyang Du, Jiheng Zhang, Jiheng Zhang, Shaoshan Hu, Shaoshan Hu

“…Meanwhile, the relatively high expression of immune checkpoints explained the immunosuppressive state of patients with high EMTrLS scores. …”
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