Hemagglutination inhibiting antibodies and protection against seasonal and pandemic influenza infection. by Fox, A, Mai, L, Thanh, LT, Wolbers, M, Le Khanh Hang, N, Thai, P, Thi Thu Yen, N, Minh Hoa, L, Bryant, J, Duong, T, Thoang, D, Barr, I, Wertheim, H, Farrar, J, Hien, N, Horby, P

“…METHODS: 940 people from 270 unvaccinated households participated in active ILI surveillance spanning 3 influenza seasons. At least 494 provided paired blood samples spanning each season. …”

Nonannual seasonality of influenza-like illness in a tropical urban setting by Lam, H, Wesolowski, A, Hung, N, Nguyen, T, Nhat, N, Todd, S, Vinh, D, Vy, N, Thao, T, Thanh, N, Tin, P, Minh, N, Bryant, J, Buckee, C, Ngoc, T, Chau, N, Thwaites, G, Farrar, J, Tam, D, Vinh, H, Boni, M

“… <h4>Background</h4> <p>In temperate and subtropical climates, respiratory diseases exhibit seasonal peaks in winter. In the tropics, with no winter, peak timings are irregular.…”

Epidemiology, seasonality, and predictors of outcome of AIDS-associated Penicillium marneffei infection in Ho Chi Minh City, Viet Nam. by Le, T, Wolbers, M, Chi, N, Quang, V, Chinh, N, Lan, N, Lam, P, Kozal, M, Shikuma, C, Day, J, Farrar, J

“…METHODS: We performed a retrospective study of culture-confirmed incident penicilliosis admissions during 1996-2009 at the Hospital for Tropical Diseases in Ho Chi Minh City, Viet Nam. Seasonality of penicilliosis was assessed using cosinor models. …”

Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals by Lee, L, Ha, D, Simmons, C, Jong, D, Chau, N, Schumacher, R, Peng, Y, McMichael, A, Farrar, J, Smith, G, Townsend, A, Askonas, B, Rowland-Jones, S, Dong, T

“…An alternative approach is to stimulate pre-existing memory T cells established by seasonal human influenza A infection that could cross-react with H5N1 by targeting highly conserved internal proteins. …”

Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals. by Lee, L, Ha, D, Simmons, C, Jong, d, Chau, N, Schumacher, R, Peng, Y, Mcmichael, A, Farrar, J, Smith, G, Townsend, A, Askonas, B, Rowland-Jones, S, Dong, T

“…An alternative approach is to stimulate pre-existing memory T cells established by seasonal human influenza A infection that could cross-react with H5N1 by targeting highly conserved internal proteins. …”

Influenza A viral loads in respiratory samples collected from patients infected with pandemic H1N1, seasonal H1N1 and H3N2 viruses. by Ngaosuwankul, N, Noisumdaeng, P, Komolsiri, P, Pooruk, P, Chokephaibulkit, K, Chotpitayasunondh, T, Sangsajja, C, Chuchottaworn, C, Farrar, J, Puthavathana, P

“…Among a total of 29 patients with severe influenza enrolled in this study (12 cases of the 2009 pandemic influenza, 5 cases of seasonal H1N1 and 12 cases of seasonal H3N2 virus), NPA was found to contain significantly highest amount of viral loads and followed in order by NS and TS specimen. …”

Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals (Journal of Clinical Investigation (2008) 118, 10, (3478-3490) doi:10.1172/JCI32460) by Lee, L, Ha, D, Simmons, C, Jong, D, Van Chau, N, Schumacher, R, Peng, Y, McMichael, A, Farrar, J, Smith, G, Townsend, A, Askonas, B, Rowland-Jones, S, Dong, T

The epidemiology of interpandemic and pandemic influenza in Vietnam, 2007-2010: the Ha Nam household cohort study I. by Horby, P, Mai, L, Fox, A, Thai, P, Thi Thu Yen, N, Thanh, LT, Le Khanh Hang, N, Duong, T, Thoang, D, Farrar, J, Wolbers, M, Hien, N

“…The authors conducted prospective influenza surveillance and intermittent seroprevalence surveys in a household-based cohort in Vietnam between December 2007 and April 2010, resulting in 1,793 person-seasons of influenza surveillance. Age- and sex-standardized estimates of the risk of acquiring any influenza infection per season in persons 5 years of age or older were 21.1% (95% confidence interval: 17.4, 24.7) in season 1, 26.4% (95% confidence interval: 22.6, 30.2) in season 2, and 17.0% (95% confidence interval: 13.6, 20.4) in season 3. …”

The epidemiology of interpandemic and pandemic influenza in Vietnam, 2007-2010 by Horby, P, Mai, L, Fox, A, Thai, P, Thi Thu Yen, N, Thanh, LT, Le Khanh Hang, N, Duong, T, Thoang, D, Farrar, J, Wolbers, M, Hien, N

“…The authors conducted prospective influenza surveillance and intermittent seroprevalence surveys in a household-based cohort in Vietnam between December 2007 and April 2010, resulting in 1,793 person-seasons of influenza surveillance. Age-and sex-standardized estimates of the risk of acquiring any influenza infection per season in persons 5 years of age or older were 21.1% (95% confidence interval: 17.4, 24.7) in season 1, 26.4% (95% confidence interval: 22.6, 30.2) in season 2, and 17.0% (95% confidence interval: 13.6, 20.4) in season 3. …”

Genetic diversity and lineage dynamic of dengue virus serotype 1 (DENV-1) in Cambodia by Duong, V, Simmons, C, Gavotte, L, Viari, A, Ong, S, Chantha, N, Lennon, N, Birren, B, Vong, S, Farrar, J, Henn, M, Deubel, V, Frutos, R, Buchy, P

“… <p style="text-align:justify;"> In Cambodia, dengue virus (DENV) was first isolated in 1963 and has become endemic with peak epidemic during raining season. Since 2000, the Dengue National Control Program has reported from 10,000 to 40,000 cases per year with fatality rates ranging from 0.7 to 1.7. …”

Genetic diversity and lineage dynamic of dengue virus serotype 1 (DENV-1) in Cambodia by Duong, V, Simmons, C, Gavotte, L, Viari, A, Ong, S, Chantha, N, Lennon, N, Birren, B, Vong, S, Farrar, J, Henn, MR, Deubel, V, Frutos, R, Buchy, P

“…In Cambodia, dengue virus (DENV) was first isolated in 1963 and has become endemic with peak epidemic during raining season. Since 2000, the Dengue National Control Program has reported from 10,000 to 40,000 cases per year with fatality rates ranging from 0.7 to 1.7. …”

Genetic diversity and lineage dynamic of dengue virus serotype 1 (DENV-1) in Cambodia. by Duong, V, Simmons, C, Gavotte, L, Viari, A, Ong, S, Chantha, N, Lennon, N, Birren, B, Vong, S, Farrar, J, Henn, MR, Deubel, V, Frutos, R, Buchy, P

“…In Cambodia, dengue virus (DENV) was first isolated in 1963 and has become endemic with peak epidemic during raining season. Since 2000, the Dengue National Control Program has reported from 10,000 to 40,000 cases per year with fatality rates ranging from 0.7 to 1.7. …”

Phylogeography of recently emerged DENV-2 in southern Viet Nam by Rabaa, M, Ty Hang, V, Wills, B, Farrar, J, Simmons, C, Holmes, E

“…However, these data also indicate that more rural areas are also capable of maintaining virus populations and hence fueling DENV evolution over multiple seasons.…”

Dengue dynamics in Binh Thuan province, southern Vietnam: periodicity, synchronicity and climate variability by Thai, K, Cazelles, B, Nguyen, N, Vo, LT, Boni, M, Farrar, J, Simmons, C, Van Doorn, H, De Vries, P

“…The epidemiology is complex with long inter-epidemic intervals and endemic with seasonal fluctuations. This study was initiated to investigate dengue transmission dynamics in Binh Thuan province, southern Vietnam. …”

Respiratory Syncytial Virus and Other Viral Infections among Children under Two Years Old in Southern Vietnam 2009-2010: Clinical Characteristics and Disease Severity by Do, L, Bryant, J, Tran, A, Nguyen, B, Tran, T, Tran, Q, Vo, Q, Tran Dac, N, Trinh, H, Nguyen, T, Binh, L, Le, K, Nguyen, M, Thai, Q, Vo, T, Ngo, N, Dang, T, Cao, N, Tran, T, Ho, L, Farrar, J, de Jong, M, van Doorn, H

“…A shift in RSV subgroup predominance was observed during two consecutive rainy seasons but was not associated with severity.We report etiologies, the epidemiological and clinical characteristics of LRTI among hospitalized children under two years of age and risk factors of RSV and LRTI severity.…”

Global epidemiology of avian influenza A H5N1 virus infection in humans, 1997–2015: a systematic review of individual case data by Lai, S, Qin, Y, Cowling, B, Ren, X, Wardrop, N, Gilbert, M, Tsang, T, Wu, P, Feng, L, Jiang, H, Peng, Z, Zheng, J, Liao, Q, Li, S, Horby, P, Farrar, J, Gao, G, Tatem, A, Yu, H

“…<strong>Methods</strong> We describe the epidemiology of global human H5N1 cases spanning 18 years between 1 May 1997 and 30 April 2015, focusing on the characteristics of cases, seasonality, geographical distribution, and outcome. …”

Modelling the progression of pandemic influenza A (H1N1) in Vietnam and the opportunities for reassortment with other influenza viruses. by Boni, M, Manh, B, Thai, P, Farrar, J, Hien, T, Hien, N, Van Kinh, N, Horby, P

“…This is of greater concern in parts of Southeast Asia, where the population density is high, influenza is less seasonal, human-animal contact is common and avian influenza is still endemic. …”

The Southeast Asian Influenza Clinical Research Network: development and challenges for a new multilateral research endeavor. by Higgs, E, Hayden, F, Chotpitayasunondh, T, Whitworth, J, Farrar, J

“…The scope of research includes diagnosis, pathogenesis, treatment and prevention of human influenza due to seasonal or novel viruses. The Network has overcome numerous logistical and scientific challenges but has now successfully initiated several clinical trials. …”

A real-time RT-PCR for detection of clade 1 and 2 H5N1 influenza A virus using locked nucleic acid (LNA) TaqMan probes. by Thanh, T, Pawestri, H, Ngoc, N, Hien, V, Syahrial, H, Trung, N, van Doorn, R, Wertheim, H, Chau, N, Ha, Q, Farrar, J, Hien, T, Sedyaningsih, E, Jong, d

“…A total of 106 clinical samples (58 from patients infected with clade 1, 2.1 or 2.3 H5N1 viruses and 48 from uninfected or seasonal influenza A virus-infected individuals) were tested by the assay. …”

A real-time RT-PCR for detection of clade 1 and 2 H5N1 influenza A virus using locked nucleic acid (LNA) TaqMan probes by Thanh, T, Pawestri, H, Ngoc, N, Hien, V, Syahrial, H, Trung, N, Wertheim, H, Chau, N, Ha, D, Van Doorn, H, Farrar, J, Hien, T, Sedyaninsih, E, de Jong, M

“…A total of 106 clinical samples (58 from patients infected with clade 1, 2.1 or 2.3 H5N1 viruses and 48 from uninfected or seasonal influenza A virus-infected individuals) were tested by the assay. …”