CORPUS CALLOSUM DIFFUSION TENSOR IMAGING AS A BIOMARKER FOR MOTOR NEURONE DISEASE by Filippini, N, Douaud, G, Mackay, C, Knight, S, Talbot, K, Turner, MR

A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease. by Sexton, C, Kalu, U, Filippini, N, Mackay, C, Ebmeier, K

“…Forty-one diffusion tensor imaging studies contained data that were suitable for inclusion. …”

A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease by Sexton, C, Kalu, U, Filippini, N, Mackay, C, Ebmeier, K

“…Forty-one diffusion tensor imaging studies contained data that were suitable for inclusion. …”

Differences in integrity of white matter and changes with training in spelling impaired children: a diffusion tensor imaging study. by Gebauer, D, Fink, A, Filippini, N, Johansen-Berg, H, Reishofer, G, Koschutnig, K, Kargl, R, Purgstaller, C, Fazekas, F, Enzinger, C

“…While the functional correlates of spelling impairment have been rarely investigated, to our knowledge no study exists regarding the structural characteristics of spelling impairment and potential changes with interventions. Using diffusion tensor imaging at 3.0 T, we here therefore sought to investigate (a) differences between children with poor spelling abilities (training group and waiting group) and controls, and (b) the effects of a morpheme-based spelling intervention in children with poor spelling abilities on DTI parameters. …”

Diagnostic accuracy of diffusion tensor imaging in amyotrophic lateral sclerosis: a systematic review and individual patient data meta-analysis. by Foerster, B, Dwamena, B, Petrou, M, Carlos, R, Callaghan, B, Churchill, C, Mohamed, M, Bartels, C, Benatar, M, Bonzano, L, Ciccarelli, O, Cosottini, M, Ellis, C, Ehrenreich, H, Filippini, N, Ito, M, Kalra, S, Melhem, E, Pyra, T, Roccatagliata, L, Senda, J, Sobue, G, Turner, M, Feldman, E, Pomper, MG

“…RATIONALE AND OBJECTIVES: There have been a large number of case-control studies using diffusion tensor imaging (DTI) in amyotrophic lateral sclerosis (ALS). …”

Fractional anisotropy in the posterior limb of the internal capsule and prognosis in amyotrophic lateral sclerosis by Menke, R, Abraham, I, Thiel, C, Filippini, N, Knight, S, Talbot, K, Turner, MR

“…Design: Baseline clinical assessment and 3-T diffusion tensor imaging, repeated after approximately 6 months. …”

Fractional anisotropy in the posterior limb of the internal capsule and prognosis in amyotrophic lateral sclerosis. by Menke, R, Abraham, I, Thiel, C, Filippini, N, Knight, S, Talbot, K, Turner, M

“…OBJECTIVE: To explore the value of diffusion tensor imaging applied to those specific cerebral white matter tracts consistently involved pathologically in amyotrophic lateral sclerosis as a source of prognostic biomarkers. …”

Associations between self-reported sleep quality and white matter in community-dwelling older adults: A prospective cohort study by Sexton, C, Zsoldos, E, Filippini, N, Griffanti, L, Winkler, A, Mahmood, A, Allan, C, Topiwala, A, Kyle, S, Spiegelhalder, K, Singh-Manoux, A, Kivimaki, M, Mackay, C, Johansen-Berg, H, Ebmeier, K

“…Poor sleep quality at the time of the diffusion tensor imaging scan was associated with reduced global fractional anisotropy and increased global axial diffusivity and radial diffusivity values, with small effect sizes. …”

The APOE 4 allele modulates brain white matter integrity in healthy adults by Heise, V, Filippini, N, Ebmeier, K, MacKay, C

“…Because APOE is implicated in brain mechanisms associated with white matter (WM) development and repair, we investigated the potential role played by the APOE polymorphism on WM structure in healthy younger (aged 20-35 years) and older (aged 50-78 years) adults using diffusion tensor imaging. General reduction of fractional anisotropy and increase in mean diffusivity values was found in carriers of the APOE 4 allele relative to non-carriers. …”

The APOE ɛ4 allele modulates brain white matter integrity in healthy adults. by Heise, V, Filippini, N, Ebmeier, K, Mackay, C

“…Because APOE is implicated in brain mechanisms associated with white matter (WM) development and repair, we investigated the potential role played by the APOE polymorphism on WM structure in healthy younger (aged 20-35 years) and older (aged 50-78 years) adults using diffusion tensor imaging. General reduction of fractional anisotropy and increase in mean diffusivity values was found in carriers of the APOE ɛ4 allele relative to non-carriers. …”

Other magnetic resonance imaging techniques. by Ebmeier, K, Filippini, N, Heise, V, Sexton, C

“…Relatively new developments in MRI, such as functional MRI (fMRI), magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) are rapidly developing into imaging modalities that will become clinically available in the near future. …”

Apolipoprotein E genotype, gender and age modulate connectivity of the hippocampus in healthy adults. by Heise, V, Filippini, N, Trachtenberg, A, Suri, S, Ebmeier, K, Mackay, C

“…Resting-state functional magnetic resonance imaging and diffusion tensor imaging data from 86 cognitively healthy subjects aged 30 to 78years were analysed. …”

Brain structural and functional connectivity and the progression of neuropathology in Alzheimer's disease by Matthews, P, Filippini, N, Douaud, G

“…Structural connectivity measures derived from diffusion tensor MRI (DTI) methods offer additional markers of neuropathology arising from the secondary changes in axonal caliber and myelination that accompany decreased neuronal activity and neurodegeneration. …”

Brain structural and functional connectivity and the progression of neuropathology in Alzheimer's disease. by Matthews, P, Filippini, N, Douaud, G

“…Structural connectivity measures derived from diffusion tensor MRI (DTI) methods offer additional markers of neuropathology arising from the secondary changes in axonal caliber and myelination that accompany decreased neuronal activity and neurodegeneration. …”

Brain structural and functional connectivity and the progression of neuropathology in Alzheimer's disease by Matthews, P, Filippini, N, Douaud, G

“…Structural connectivity measures derived from diffusion tensor MRI (DTI) methods offer additional markers of neuropathology arising from the secondary changes in axonal caliber and myelination that accompany decreased neuronal activity and neurodegeneration. …”

Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis. by Filippini, N, Douaud, G, Mackay, C, Knight, S, Talbot, K, Turner, M

“…METHODS: In this observational study, diffusion tensor imaging was applied in a whole-brain analysis of 24 heterogeneous patients with ALS and well-matched healthy controls. …”

Integration of structural and functional magnetic resonance imaging in amyotrophic lateral sclerosis. by Douaud, G, Filippini, N, Knight, S, Talbot, K, Turner, M

“…The functional correlates of the structural changes detected using advanced magnetic resonance imaging techniques such as diffusion tensor imaging and voxel-based morphometry have not been extensively studied. …”

Integration of structural and functional magnetic resonance imaging in amyotrophic lateral sclerosis by Douaud, G, Filippini, N, Knight, S, Talbot, K, Turner, MR

“…The functional correlates of the structural changes detected using advanced magnetic resonance imaging techniques such as diffusion tensor imaging and voxel-based morphometry have not been extensively studied. …”

Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis. by Menke, R, Körner, S, Filippini, N, Douaud, G, Knight, S, Talbot, K, Turner, M

“…White matter pathology was assessed using tract-based spatial statistics analysis of indices derived from diffusion tensor imaging. Cross-sectional analyses included group comparison with a group of healthy controls (n = 36) and correlations with clinical features, including regional disability, clinical upper motor neuron signs and cognitive impairment. …”