A population-based study of personality in 34,000 sib-pairs. by Martin, N, Goodwin, G, Fairburn, C, Wilson, R, Allison, D, Cardon, L, Flint, J

“…As the first step in developing a large randomly-ascertained family cohort in southwest England, a sample of 88,000 individuals, including more than 34,000 sibling pairs in 20,000 sibships, was administered the Eysenck Personality Questionnaire (EPQ) by commercial mailing. …”

A whole genome association study of neuroticism using DNA pooling. by Shifman, S, Bhomra, A, Smiley, S, Wray, N, James, MR, Martin, N, Hettema, J, An, S, Neale, M, van den Oord, E, Kendler, K, Chen, X, Boomsma, D, Middeldorp, C, Hottenga, J, Slagboom, P, Flint, J

“…Whole genome association with 452 574 SNPs was performed on DNA pools from approximately 2000 individuals selected on extremes of neuroticism scores from a cohort of 88 142 people from southwest England. The most significant SNPs were then genotyped on independent samples to replicate findings. …”

Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus. by Fullerton, J, Willis-Owen, SA, Yalcin, B, Shifman, S, Copley, R, Miller, SR, Bhomra, A, Davidson, S, Oliver, P, Mott, R, Flint, J

“…Genetic association with neuroticism was tested in 1869 high and 2032 low unrelated individuals scored for neuroticism, selected from the extremes of 88,141 people from southwest England. RESULTS: Fifteen sequence variants contributed to variation in the expression of rgs18, the gene lying at the edge of the quantitative trait loci (QTL) interval. …”