The CRTC1-SIK1 pathway regulates entrainment of the circadian clock. by Jagannath, A, Butler, R, Godinho, S, Couch, Y, Brown, L, Vasudevan, SR, Flanagan, K, Anthony, D, Churchill, G, Wood, M, Steiner, G, Ebeling, M, Hossbach, M, Wettstein, J, Duffield, G, Gatti, S, Hankins, M, Foster, R, Peirson, S

“…Our detailed understanding of this pathway is poor, and it remains unclear why entrainment to a new time zone takes several days. By analyzing the light-regulated transcriptome of the SCN, we have identified a key role for salt inducible kinase 1 (SIK1) and CREB-regulated transcription coactivator 1 (CRTC1) in clock re-setting. …”

The rhythms of life: what your body clock means to you! by Foster, R, Kreitzman, L

“…Until we turned our nights into days and began to travel in aircraft across multiple time zones, we were largely unaware that we possess a 'day within' driven by an internal body clock. …”