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Helminth co-infection in Helicobacter pylori infected INS-GAS mice attenuates gastric premalignant lesions of epithelial dysplasia and glandular atrophy and preserves colonization resistance of the stomach to lower bowel microbiota
Published 2015“…Identifying how helminths reduce gastric premalignant lesions and impact bacterial colonization of the H. pylori infected stomach could lead to new treatment strategies to inhibit progression from chronic gastritis to cancer in humans.…”
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IL-11 is a parietal cell cytokine that induces atrophic gastritis
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Denervation suppresses gastric tumorigenesis
Published 2015“…In three separate mouse models of gastric cancer, surgical or pharmacological denervation of the stomach (bilateral or unilateral truncal vagotomy, or local injection of botulinum toxin type A) markedly reduced tumor incidence and progression, but only in the denervated portion of the stomach. …”
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Obesity accelerates Helicobacter felis-induced gastric carcinogenesis by enhancing immature myeloid cell trafficking and TH17 response
Published 2014“…Study animals were analysed for gastric and adipose pathology, inflammatory markers in serum, stomach and adipose tissue, and immune responses in blood, spleen, stomach and adipose tissue. …”
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Helicobacter pylori Infection Promotes Methylation and Silencing of Trefoil Factor 2, Leading to Gastric Tumor Development in Mice and Humans
Published 2015“…Background & Aims Trefoil factors (TFFs) regulate mucosal repair and suppress tumor formation in the stomach. Tff1 deficiency results in gastric cancer, whereas Tff2 deficiency increases gastric inflammation. …”
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Long-term proton pump inhibitor administration, H pylori and gastric cancer: lessons from the gerbil
Published 2011“…The association between chronic active gastritis and pre-neoplastic conditions as well as invasive cancer of the stomach was established several decades ago. The risk of progression depended on the severity and distribution of gastritis, with cancer, in particular, occurring in subjects with pan-gastritis. …”
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Differentiation of Gastric Helicobacter Species Using MALDI-TOF Mass Spectrometry
Published 2021“…</i>) <i>pylori</i> and non-<i>H. pylori Helicobacter</i> species (NHPHs)) colonize the stomach of humans and/or animals. <i>Helicobacter</i> species identification is essential since many of them are recognized as human and/or animal pathogens. …”
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Helicobacter Species Identified in Captive Sooty Mangabeys (Cercocebus atys) with Metastatic Gastric Adenocarcinoma
Published 2020“…Materials and Methods: In this study, using archived formalin-fixed, paraffin-embedded stomach sections of these animals alternative methodologies were used to identify H. pylori and other non-H. pylori Helicobacter species. …”
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Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors
Published 2012“…Gastric tissue was analysed by histopathology and cells isolated from the stomach were analysed by molecular biological methods. …”
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Isolation of a Campylobacter lanienae-like Bacterium from Laboratory Chinchillas (Chinchilla laniger)
Published 2015“…There was no correlation between colonization status and lesion severity in the stomach, liver, duodenum, or colon. Possible routes of C. lanienae infection in chinchillas could include waterborne transmission and faecal–oral transmission from wild mice and rats or livestock. …”
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Epigenetic regulation of Delta-Like1 controls Notch1 activation in gastric cancer
Published 2012“…Aberrant activation of Notch signaling has been described in several tumours and in gastric cancer (GC), activated Notch1 has been associated with de-differentiation of lineage-committed stomach cells into stem progenitors and GC progression. …”
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Mutagenic potency of Helicobacter pylori in the gastric mucosa of mice determined by sex and duration of infection
Published 2011“…Earlier onset of severe gastric lesions and proinflammatory, Th1-biased responses in female C57BL/6 mice may have promoted mutagenesis by exposing the stomach to prolonged oxidative stress.…”
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Lack of Commensal Flora in H. pylori–Infected INS-GAS Mice Reduces Gastritis and Delays Intraepithelial Neoplasia
Published 2015“…Changes in gastric microbiota composition might promote GIN in achlorhydric stomachs of SPF mice.…”
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Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression
Published 2012“…Objectives: Spasmolytic polypeptide-expressing metaplasia (SPEM) develops as a preneoplastic lesion in the stomachs of mice and humans after parietal cell loss. …”
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Attenuation of H-Pylori-Induced Gastric Pathology in C57bl/6 Mice by Co-Infection with Enterohepatic Helicobacters Is Helicobacter Species-Dependent
Published 2013“…Hm-mediated attenuated pathology was associated with significant downregulation of proinflammatory Th1 (IL1, IFN[[Unsupported Character - ]] and TNF) and Th17 (IL-17A) cytokine mRNA levels in stomachs when compared to the Hp-infected mice. Although co-infection with Hh suppressed Hp-induced elevation of gastric Th1 cytokines, Th17 cytokine mRNA levels were increased. …”
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