The Interleukin 33–T Helper 2 Cell Axis Promotes Human Liver Fibrosis by Isabella Lurje, Frank Tacke

Get full text

Single-cell landscape of immune cells in human livers affected by HBV-related cirrhosis by Qingquan Bai, Xiaoting Hong, Han Lin, Xiao He, Runyang Li, Mohsin Hassan, Hilmar Berger, Frank Tacke, Cornelius Engelmann, Tianhui Hu

Get full text

Cyclin E1 in Murine and Human Liver Cancer: A Promising Target for Therapeutic Intervention during Tumour Progression by Roland Sonntag, Christian Penners, Marlene Kohlhepp, Ute Haas, Daniela Lambertz, Andreas Kroh, Thorsten Cramer, Fabio Ticconi, Ivan G. Costa, Frank Tacke, Nikolaus Gassler, Christian Trautwein, Christian Liedtke

Get full text

In Vitro Models for the Study of Liver Biology and Diseases: Advances and LimitationsSummary by Savneet Kaur, Srivatsan Kidambi, Martí Ortega-Ribera, Le Thi Thanh Thuy, Natalia Nieto, Victoria C. Cogger, Wei-Fen Xie, Frank Tacke, Jordi Gracia-Sancho

“…Based on cell lines, induced pluripotent stem cells or primary cells derived from mouse or human liver as well as whole tissue (slices), such in vitro single- and multicellular models, including complex microfluidic organ-on-a-chip systems, provide tools to functionally understand mechanisms of liver health and disease. …”
Get full text

Single-cell landscape of immune cells during the progression from HBV infection to HBV cirrhosis and HBV-associated hepatocellular carcinoma by Qingquan Bai, Qingquan Bai, Runyang Li, Xiao He, Xiaoting Hong, Ying Yan, Zhengyang Zhao, Han Lin, Frank Tacke, Cornelius Engelmann, Cornelius Engelmann, Cornelius Engelmann, Tianhui Hu, Tianhui Hu

“…However, their functions at different disease stages are not fully understood.MethodsIn this study, we used single-cell RNA sequencing (scRNA-seq) to characterize the human liver immune microenvironment at different disease stages. …”
Get full text

Prevention and Management of CMV Infections after Liver Transplantation: Current Practice in German Transplant Centers by Cornelius Engelmann, Martina Sterneck, Karl Heinz Weiss, Silke Templin, Steffen Zopf, Gerald Denk, Dennis Eurich, Johann Pratschke, Johannes Weiss, Felix Braun, Martin-Walter Welker, Tim Zimmermann, Petra Knipper, Dirk Nierhoff, Thomas Lorf, Elmar Jäckel, Hans-Michael Hau, Tung Yu Tsui, Aristoteles Perrakis, Hans-Jürgen Schlitt, Kerstin Herzer, Frank Tacke

“…Human cytomegalovirus (CMV) remains a major cause of mortality and morbidity in human liver transplant recipients. Anti-CMV therapeutics can be used to prevent or treat CMV in liver transplant recipients, but their toxicity needs to be balanced against the benefits. …”
Get full text