Mechanisms underlying the efficacy of normothermic machine perfusion in human liver transplantation by Nasralla, D

“…Herein is reported the first randomised controlled trial (RCT) comparing continuous NMP with SCS in human liver transplantation. Additional work exploring the mechanisms behind the effects of NMP is also described.…”

A study of hepatocyte ischaemia-reperfusion injury and steatosis in a human liver stem cell model by Sivathondan, P, Hodson, L, Dragovic, R, Silva, M, Friend, P, Morten, K

Immuno-molecular profiling and modulation of donor livers during normothermic machine perfusion by Dengu, F

“…Through an evaluation of samples from clinical trials of human liver perfusion, I have demonstrated that ex situ reperfusion injury/inflammation (ERI) is an immunologically and molecularly distinct entity observed consistently across livers preserved with NMP. …”

Ex-vivo normothermic liver perfusion: an update. by Vogel, T, Brockmann, J, Friend, P

“…The current challenges are, first to confirm the feasibility of the normothermic machine perfusion methodology in human livers and, second, to develop and introduce a functional device into the clinical arena.…”

Defatting of donor transplant livers during normothermic perfusion - a randomised clinical trial: study protocol for the DeFat study by Abbas, SH, Ceresa, CDL, Hodson, L, Coussios, C, Kounali, D, Knight, S, Friend, P

“…We have recently tested defatting interventions during normothermic machine perfusion (NMP) in discarded steatotic human livers that were not transplanted. A combination of therapies including forskolin (NKH477) and L-carnitine to defat liver cells and lipoprotein apheresis filtration were investigated. …”