The Cell Adhesion Molecule L1 Interacts with Methyl CpG Binding Protein 2 via Its Intracellular Domain by Gabriele Loers, Ralf Kleene, Maria Girbes Minguez, Melitta Schachner

Subjects: “…cell adhesion molecule L1…”
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The KDET Motif in the Intracellular Domain of the Cell Adhesion Molecule L1 Interacts with Several Nuclear, Cytoplasmic, and Mitochondrial Proteins Essential for Neuronal Functions by Ralf Kleene, Gabriele Loers, Melitta Schachner

Subjects: “…cell adhesion molecule L1…”
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Antibody fragments directed against different portions of the human neural cell adhesion molecule L1 act as inhibitors or activators of L1 function. by Yan Wang, Gabriele Loers, Hong-Chao Pan, Ricardo Gouveia, Wei-Jiang Zhao, Yan-Qin Shen, Ralf Kleene, Julia Costa, Melitta Schachner

“…The neural cell adhesion molecule L1 plays important roles in neuronal migration and survival, neuritogenesis and synaptogenesis. …”
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The Interactions of the 70 kDa Fragment of Cell Adhesion Molecule L1 with Topoisomerase 1, Peroxisome Proliferator-Activated Receptor γ and NADH Dehydrogenase (Ubiquinone) Flavoprotein 2 Are Involved in Gene Expression and Neuronal L1-Dependent Functions by Gabriele Loers, Ralf Kleene, Ute Bork, Melitta Schachner

Subjects: “…cell adhesion molecule L1…”
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Interaction of L1CAM with LC3 Is Required for L1-Dependent Neurite Outgrowth and Neuronal Survival by Gabriele Loers, Ralf Kleene, Viviana Granato, Ute Bork, Melitta Schachner

Subjects: “…neural cell adhesion molecule L1…”
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Mitochondrial and Neuronal Dysfunctions in L1 Mutant Mice by Ludovica Congiu, Viviana Granato, Gabriele Loers, Ralf Kleene, Melitta Schachner

Subjects: “…cell adhesion molecule L1…”
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Mice Mutated in the Third Fibronectin Domain of L1 Show Enhanced Hippocampal Neuronal Cell Death, Astrogliosis and Alterations in Behavior by Ludovica Congiu, Viviana Granato, Igor Jakovcevski, Ralf Kleene, Luciana Fernandes, Sandra Freitag, Matthias Kneussel, Melitta Schachner, Gabriele Loers

“…Adhesion molecules play major roles in cell proliferation, migration, survival, neurite outgrowth and synapse formation during nervous system development and in adulthood. The neural cell adhesion molecule L1 contributes to these functions during development and in synapse formation and synaptic plasticity after trauma in adulthood. …”
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CHL1 depletion affects dopamine receptor D2-dependent modulation of mouse behavior by Luciana Fernandes, Ralf Kleene, Ludovica Congiu, Sandra Freitag, Matthias Kneussel, Gabriele Loers, Melitta Schachner

“…IntroductionThe dopaminergic system plays a key role in the appropriate functioning of the central nervous system, where it is essential for emotional balance, arousal, reward, and motor control. The cell adhesion molecule close homolog of L1 (CHL1) contributes to dopaminergic system development, and CHL1 and the dopamine receptor D2 (D2R) are associated with mental disorders like schizophrenia, addiction, autism spectrum disorder and depression.MethodsHere, we investigated how the interplay between CHL1 and D2R affects the behavior of young adult male and female wild-type (CHL+/+) and CHL1-deficient (CHL1−/−) mice, when D2R agonist quinpirole and antagonist sulpiride are applied.ResultsLow doses of quinpirole (0.02 mg/kg body weight) induced hypolocomotion of CHL1+/+ and CHL1−/− males and females, but led to a delayed response in CHL1−/− mice. …”
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