Collagen-specific cytotoxic T lymphocyte responses in patients with ankylosing spondylitis and reactive arthritis. by Gao, X, Wordsworth, P, McMichael, A

“…Both ankylosing spondylitis (AS) and reactive arthritis (ReA) are strongly associated with HLA-B27 although the mechanism for this association is still unknown. …”

A study on homocysteine-specific CTL from patients with ankylosing spondylitis and reactive arthritis by Gao, X, Chilvers, M, Wordsworth, P

Homocysteine modification of HLA antigens and its immunological consequences. by Gao, X, Wordsworth, P, Mcmichael, A, Kyaw, M, Seifert, M, Rees, D, Dougan, G

“…Homocysteine-treated cells can be specifically lysed by cytotoxic T lymphocytes (CTL) identifiable in patients with ankylosing spondylitis and reactive arthritis. Sensitization of target cells involves disulfide bonding and the interaction between homocysteine and HLA antigens occurs in a pre-Golgi compartment in the cells. …”

TCR usage by homocysteine-specific human CTL. by Chilvers, M, Wordsworth, P, Stubbs, A, Gao, X

“…Here, we have investigated TCR usage by Hom-CTL from five patients with ankylosing spondylitis or reactive arthritis. TCR of HLA-A68-restricted Hom-CTL from two unrelated donors share the same TCR Valpha, Vbeta, and Jbeta gene segments (AV4, BV23, and BJ2S1, respectively) with similar third complementarity determining regions (CDR3) of the beta-chains. …”