Antidepressant controlled trial for negative symptoms in schizophrenia (ACTIONS): a double-blind, placebo-controlled, randomised clinical trial. by Barnes, T, Leeson, V, Paton, C, Costelloe, C, Simon, J, Kiss, N, Osborn, D, Killaspy, H, Craig, T, Lewis, S, Keown, P, Ismail, S, Crawford, M, Baldwin, D, Lewis, G, Geddes, J, Kumar, M, Pathak, R, Taylor, S

“…</p> <h4>Design</h4> <p>A multicentre, double-blind, individually randomised, placebo-controlled trial with 12-month follow-up</p> <h4>Setting</h4> <p>Adult psychiatric services, treating people with schizophrenia.…”

An investigation of levetiracetam in Alzheimer's disease (ILiAD): a double-blind, placebo-controlled, randomised crossover proof of concept study by Sen, A, Akinola, M, Tai, XY, Symmonds, M, Davis Jones, G, Mura, S, Galloway, J, Hallam, A, Chan, JYC, Koychev, I, Butler, C, Geddes, J, Van Der Putt, R, Thompson, S, Manohar, SG, Frangou, E, Love, S, McShane, R, Husain, M

“…Participants will be allocated to a double-blind placebo-controlled crossover trial that tests levetiracetam against placebo. …”

Folic acid supplementation for prevention of mood disorders in young people at familial risk: a randomised, double blind, placebo controlled trial. by Sharpley, A, Hockney, R, McPeake, L, Geddes, J, Cowen, P

“…METHOD: A randomised, double blind, parallel group, placebo-controlled trial in which participants, aged 14-24 years, at increased familial risk of mood disorder, were randomised to folic acid (2.5 mg daily) or identical placebo liquid for a maximum of 36 months. …”

Efficacy of cognitive behavioural therapy for sleep improvement in patients with persistent delusions and hallucinations (BEST): a prospective, assessor-blind, randomised controlled pilot trial by Freeman, D, Waite, F, Startup, H, Startup, H, Myers, E, Lister, R, McInerney, J, Harvey, A, Geddes, J, Zaiwalla, Z, Luengo-Fernandez, R, Foster, R, Clifton, L, Yu, L

“…Methods We did this prospective, assessor-blind, randomised controlled pilot trial (Better Sleep Trial [BEST]) at two mental health centres in the UK. …”

Fluvoxamine and graded psychotherapy in the treatment of bulimia nervosa: a randomized, double-blind, placebo-controlled, multicenter study of short-term and long-term pharmacotherapy combined with a stepped care approach to psychotherapy. by Schmidt, U, Cooper, P, Essers, H, Freeman, C, Holland, R, Palmer, R, Shur, E, Russell, G, Bowler, C, Coker, S, Geddes, J, Mackenzie, F, Munro, J, Newton, R, Tiller, J, Tattersall, M, Vize, C, Webster, J

Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: systematic review, meta-analysis, and rationale by Hong, J, Atkinson, L, Al-Juffali, N, Awad, A, Geddes, J, Tunbridge, E, Harrison, P, Cipriani, A

“…For bipolar disorder, four double-blind RCTs investigating gabapentin, and no double-blind RCTs investigating pregabalin, were identified. …”

Are all antidepressants really the same? The case of fluoxetine: a systematic review. by Cipriani, A, Barbui, C, Brambilla, P, Furukawa, T, Hotopf, M, Geddes, J

“…STUDY SELECTION: Only randomized controlled trials (either blind or nonblind) were included. DATA SYNTHESIS: 131 randomized controlled trials were eligible. …”

Biological rationale and potential clinical use of gabapentin and pregabalin in bipolar disorder, insomnia and anxiety. Protocol for a systematic review by Houghton, K, Forrest, A, Awad, A, Cipriani, A, Atkinson, L, Stockton, S, Harrison, P, Geddes, J

“…For consideration of adverse effects (tolerability), single blind or open label RCTs and non-randomised evidence will also be summarised. …”

Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: A multiple-treatments meta-analysis by Leucht, S, Örey, D, Richter, F, Samara, M, Kissling, W, Stapf, M, Lässig, B, Cipriani, A, Barbui, C, Spineli, L, Mavridis, D, Salanti, G, Engel, R, Geddes, J, Davis, J

“…Search results were supplemented by reports from the US Food and Drug Administration website and by data requested from pharmaceutical companies. Blinded, randomised controlled trials of patients with schizophrenia or related disorders were eligible. …”

Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. by Leucht, S, Cipriani, A, Spineli, L, Mavridis, D, Orey, D, Richter, F, Samara, M, Barbui, C, Engel, R, Geddes, J, Kissling, W, Stapf, M, Lässig, B, Salanti, G, Davis, J

“…Search results were supplemented by reports from the US Food and Drug Administration website and by data requested from pharmaceutical companies. Blinded, randomised controlled trials of patients with schizophrenia or related disorders were eligible. …”

Oxford Lithium Trial (OxLith) of the early affective, cognitive, neural and biochemical effects of lithium carbonate in bipolar disorder: study protocol for a randomised controlled... by Saunders, K, Cipriani, A, Rendell, J, Attenburrow, M, Nelissen, N, Bilderbeck, A, Vasudevan, S, Churchill, G, Goodwin, G, Nobre, A, Harmer, C, Harrison, P, Geddes, J

“…Despite lithium's being the most effective drug for bipolar disorder and in clinical use for decades, we still know very little about its early effects relevant to its mode of action.The Oxford Lithium Trial is a double-blind, randomised, placebo-controlled study of 6-week lithium treatment in participants with bipolar disorder and mood instability. …”

Clinical and regulatory implications of active run-in phases in long-term studies for bipolar disorder by Cipriani, A, Barbui, C, Rendell, J, Geddes, J

“…Method: Systematic review of double-blind RCTs comparing SGAs with placebo or active drugs in adults. …”

Oxford Lithium Trial (OxLith) of the early affective, cognitive, neural and biochemical effects of lithium carbonate in bipolar disorder: study protocol for a randomized controlled... by Saunders, K, Cipriani, A, Rendell, J, Attenburrow, M, Nelissen, N, Bilderbeck, A, Vasudevan, S, Churchill, G, Goodwin, G, Nobre, A, Harmer, C, Harrison, P, Geddes, J

“…<strong>Methods / design:</strong> OxLith is a double blind, randomised, placebo controlled study of 6 weeks’ lithium treatment in participants with bipolar disorder and mood instability which aims to identify early clinical, neurocognitive and biological effects. …”

Clinical and regulatory implications of active run-in phases in long-term studies for bipolar disorder. by Cipriani, A, Barbui, C, Rendell, J, Geddes, J

“…METHOD: Systematic review of double-blind RCTs comparing SGAs with placebo or active drugs in adults. …”

A systematic review of calcium channel antagonists in bipolar disorder and some considerations for their future development by Cipriani, A, Saunders, K, Attenburrow, M, Panchal, P, Lane, Tunbridge, E, Geddes, J, Harrison, P, Lane, T, Stockton, S, Stefaniak, J

“…We identified 23 eligible studies, with six randomised, double-blind, controlled clinical trials, all of which investigated verapamil in acute mania, and finding no evidence that it is effective. …”

Inositol for depressive disorders. by Taylor, M, Wilder, H, Bhagwagar, Z, Geddes, J

“…These were short term trials of double-blind design. The trials did not show clear evidence of a therapeutic benefit, nor any evidence of poor acceptability. …”

The Oxford study of calcium channel antagonism, cognition, mood instability and sleep (OxCaMS): Study protocol for a randomised controlled, experimental medicine study by Atkinson, L, Colbourne, L, Smith, A, Harmer, C, Nobre, A, Rendell, J, Jones, H, Hinds, C, Mould, A, Tunbridge, E, Cipriani, A, Geddes, J, Saunders, K, Harrison, P

“…</p><br/> <p><strong>Methods</strong><br/> The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS) is a high-intensity randomised, double-blind, placebo-controlled experimental medicine study on the effect of the LTCC antagonist nicardipine in healthy young adults with mood instability. …”

Comparative efficacy and acceptability of pharmacological treatments for post-traumatic stress disorder in adults: a network meta-analysis by Cipriani, A, Williams, T, Nikolakopoulou, A, Salanti, G, Chaimani, A, Ipser, J, Cowen, P, Geddes, J, Stein, D

“…</p> <h4>Methods</h4> <p>Cochrane Central Register of Controlled Trials register, MEDLINE, PsycINFO, National PTSD Center Pilots database, PubMed, trial registries and databases of pharmaceutical companies were searched until February 2016 for double-blind randomised trials comparing any pharmacological intervention or placebo as oral therapy in adults with PTSD. …”

Comparative efficacy and acceptability of first-generation and second-generation antidepressants in the acute treatment of major depression: protocol for a network meta-analysis. by Furukawa, T, Salanti, G, Atkinson, L, Leucht, S, Ruhe, H, Turner, E, Chaimani, A, Ogawa, Y, Takeshima, N, Hayasaka, Y, Imai, H, Shinohara, K, Suganuma, A, Watanabe, N, Stockton, S, Geddes, J, Cipriani, A

“…Here, we present a protocol for a systematic review and network meta-analysis aimed at updating the evidence base and comparing all second-generation as well as selected first-generation antidepressants in terms of efficacy and acceptability in the acute treatment of major depression.We will include all randomised controlled trials reported as double-blind and comparing one active drug with another or with placebo in the acute phase treatment of major depression in adults. …”

Topiramate for acute affective episodes in bipolar disorder in adults by Pigott, K, Galizia, I, Vasudev, K, Watson, S, Geddes, J, Young, A

“…As we graded the quality of the evidence for the other findings as low and very low, it was not possible to draw any conclusions from the results.To best address this research question, if investigators see the indication in so doing, more double-blind randomised controlled trials could be conducted that are more explicit with regard to methodological issues. …”