Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation. by Anthis, N, Haling, JR, Oxley, C, Memo, M, Wegener, K, Lim, C, Ginsberg, M, Campbell, I

“…Integrins are large membrane-spanning receptors fundamental to cell adhesion and migration. …”

A membrane-distal segment of the integrin alpha IIb cytoplasmic domain regulates integrin activation. by Ginsberg, M, Yaspan, B, Forsyth, J, Ulmer, T, Campbell, I, Slepak, M

“…Previous evidence suggests that interactions between integrin cytoplasmic domains regulate integrin activation. …”

Structural basis of integrin activation by talin. by Wegener, K, Partridge, A, Han, J, Pickford, A, Liddington, R, Ginsberg, M, Campbell, I

“…Regulation of integrin affinity (activation) is essential for metazoan development and for many pathological processes. …”

Structural determinants of integrin recognition by talin. by García-Alvarez, B, de Pereda, J, Calderwood, D, Ulmer, T, Critchley, D, Campbell, I, Ginsberg, M, Liddington, R

“…Here we report the crystal structure of the principal integrin binding and activating fragment of talin, alone and in complex with fragments of the beta 3 integrin tail. …”

The talin-tail interaction places integrin activation on FERM ground. by Campbell, I, Ginsberg, M

“…Cellular regulation of the affinity of integrins for ligands - so-called 'integrin activation' - is a central property of these receptors. …”

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. by Anthis, N, Wegener, K, Ye, F, Kim, C, Goult, B, Lowe, E, Vakonakis, I, Bate, N, Critchley, DR, Ginsberg, M, Campbell, I

“…Fundamental to cell adhesion and migration, integrins are large heterodimeric membrane proteins that uniquely mediate inside-out signal transduction, whereby adhesion to the extracellular matrix is activated from within the cell by direct binding of talin to the cytoplasmic tail of the beta integrin subunit. …”

Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit. by Ulmer, T, Calderwood, D, Ginsberg, M, Campbell, I

“…Talin connects integrins with actin filaments and influences integrin affinity by binding to the integrins' short cytoplasmic beta-tail. …”

NMR analysis of structure and dynamics of the cytosolic tails of integrin alpha IIb beta 3 in aqueous solution. by Ulmer, T, Yaspan, B, Ginsberg, M, Campbell, I

“…The structural and dynamic properties of the cytosolic tails of the adhesion receptor integrin alphaIIbbeta3, fused to a coiled-coil construct via (Gly)(3) linkers, were studied in aqueous solution by nuclear magnetic resonance (NMR) spectroscopy. …”

Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions. by de Pereda, J, Wegener, K, Santelli, E, Bate, N, Ginsberg, M, Critchley, DR, Campbell, I, Liddington, R

“…Our data are consistent with the proposal that Src activity promotes a switch from integrin binding to PIPKIgamma binding that regulates focal adhesion turnover.…”