Scavenger receptor B1 involvement in chronic obstructive pulmonary disease pathogenesis by Carlo Cervellati, Paolo Casolari, Alessandra Pecorelli, Claudia Sticozzi, Francesco Nucera, Alberto Papi, Gaetano Caramori, Giuseppe Valacchi

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Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid by Maddalena Sguizzato, Paolo Mariani, Francesca Ferrara, Markus Drechsler, Supandeep Singh Hallan, Nicolas Huang, Fanny Simelière, Nikul Khunti, Rita Cortesi, Nicola Marchetti, Giuseppe Valacchi, Elisabetta Esposito

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Ultraviolet Light Protection: Is It Really Enough? by Patricia K. Farris, Giuseppe Valacchi

“…Our current understanding of the pathogenesis of skin aging includes the role of ultraviolet light, visible light, infrared, pollution, cigarette smoke and other environmental exposures. The mechanism of action common to these exposures is the disruption of the cellular redox balance by the directly or indirectly increased formation of reactive oxygen species that overwhelm the intrinsic antioxidant defense system, resulting in an oxidative stress condition. …”
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Comparison of Pollutant Effects on Cutaneous Inflammasomes Activation by John Ivarsson, Francesca Ferrara, Andrea Vallese, Anna Guiotto, Sante Colella, Alessandra Pecorelli, Giuseppe Valacchi

“…In this study, human skin explants were exposed to the best-recognized air pollutants, such as microplastics (MP), cigarette smoke (CS), diesel engine exhaust (DEE), ozone (O₃), and UV, for 1 or 4 days, to explore how each pollutant can differently modulate markers of cutaneous oxinflammation. …”
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Ethosomes and Transethosomes for Mangiferin Transdermal Delivery by Maddalena Sguizzato, Francesca Ferrara, Supandeep Singh Hallan, Anna Baldisserotto, Markus Drechsler, Manuela Malatesta, Manuela Costanzo, Rita Cortesi, Carmelo Puglia, Giuseppe Valacchi, Elisabetta Esposito

“…The suitability of mangiferin-containing nanovesicles in the treatment of skin disorders related to pollutants was investigated, evaluating, in vitro, the antioxidant and anti-inflammatory effect of ethosomes and transethosomes on human keratinocytes exposed to cigarette smoke as an oxidative and inflammatory challenger. …”
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Cutaneous Redox Senescence by Mariáurea Matias Sarandy, Reggiani Vilela Gonçalves, Giuseppe Valacchi

“…Our current understanding of skin cell senescence involves the role of environmental stressors (UV, O₃, cigarette smoke, particulate matter, etc.), lifestyle (diet, exercise, etc.) as well as genetic factors (metabolic changes, hormonal, etc.). …”
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Ubiquitination as a key regulatory mechanism for O3-induced cutaneous redox inflammasome activation by Francesca Ferrara, Valeria Cordone, Alessandra Pecorelli, Mascia Benedusi, Erika Pambianchi, Anna Guiotto, Andrea Vallese, Franco Cervellati, Giuseppe Valacchi

“…In the past decades a crescent number of studies have highlighted the role of air pollutants as Particulate Matter (PM), Cigarette Smoke (CS) and Ozone (O3) as trigger stimuli for inflammasomes activation, especially via Reactive Oxygen Species (ROS) mediators. …”
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