Imaging nociceptive brain activity in the newborn infant by Goksan, S

“…<p>In this thesis electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) are used to investigate the temporal and spatial patterns of noxious-evoked brain activity in newborn infants. EEG was used to investigate responses to graded intensities of experimental noxious stimulation, and evoked brain activity was compared with behavioural and spinal cord activity constituting common surrogate measures of pain in infants. …”

Stroking modulates noxious-evoked brain activity in human infants by Gursul, D, Goksan, S, Hartley, C, Shmidt Mellado, G, Moultrie, F, Hoskin, A, Adams, E, Hathway, G, Walker, S, McGlone, F, Slater, R

The influence of the descending pain modulatory system on infant pain-related brain activity by Goksan, S, Baxter, L, Moultrie, F, Duff, E, Hathway, G, Hartley, C, Tracey, I, Slater, R

“…Greater pre-stimulus functional network connectivity across the DPMS was significantly associated with lower noxious-evoked brain activity (p=0.0004, r=-0.86, n=13), suggesting that in newborn infants the DPMS may regulate the magnitude of noxious-evoked brain activity.…”

Noxious stimulation in children receiving general anaesthesia evokes an increase in delta frequency brain activity. by Hartley, C, Poorun, R, Goksan, S, Worley, A, Boyd, S, Rogers, R, Ali, T, Slater, R

“…More than 235,000children/year in the UK receive general anaesthesia, but it is unknown whether nociceptive stimuli alter cortical brain activity in anaesthetised children. Time-locked electroencephalogram (EEG) responses to experimental tactile stimuli, experimental noxious stimuli, and clinically required cannulation were examined in 51 children (ages 1-12years) under sevoflurane monoanaesthesia. …”

Optimising neonatal fMRI data analysis: Design and validation of an extended dHCP preprocessing pipeline to characterise noxious-evoked brain activity in infants by Baxter, L, Fitzgibbon, S, Moultrie, F, Goksan, S, Jenkinson, M, Smith, S, Andersson, J, Duff, E, Slater, R

“…We describe and validate this extended dHCP fMRI preprocessing pipeline to analyse changes in brain activity evoked following an acute noxious stimulus applied to the infant's foot. …”

Birth experience in newborn infants is associated with changes in nociceptive sensitivity by Kasser, S, Hartley, C, Rickenbacher, H, Klarer, N, Depoorter, A, Datta, A, Cobo, M, Goksan, S, Hoskin, A, Magerl, W, Huhn, E, Green, G, Slater, R, Wellmann, S

“…We hypothesize that infants born by vaginal delivery will show lower noxious-evoked brain activity a few hours after birth compared to those born by elective cesarean section. …”

Inferring pain experience in infants using quantitative whole-brain functional MRI signatures: a cross-sectional, observational study by Duff, E, Moultrie, F, van der Vaart, M, Goksan, S, Abos, A, Fitzgibbon, S, Baxter, L, Wager, TD, Slater, R

“…We also assessed brain activity in pro-pain and anti-pain components of the signatures. …”

Inferring pain experience in infants using quantitative whole-brain functional MRI signatures: a cross-sectional, observational study by Duff, EP, Moultrie, F, van der Vaart, M, Goksan, S, Abos, A, Fitzgibbon, SP, Baxter, L, Wager, TD, Slater, R

“…We also assessed brain activity in pro-pain and anti-pain components of the signatures.…”

Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial by Hartley, C, Moultrie, F, Hoskin, A, Green, G, Monk, V, Bell, J, King, A, Buckle, M, van Der Vaart, M, Gursul, D, Goksan, S, Juszczak, E, Norman, J, Rogers, R, Patel, C, Adams, E, Slater, R

“…The co-primary outcome measures were the Premature Infant Pain Profile–Revised (PIPP-R) score after retinopathy of prematurity screening and the magnitude of noxious-evoked brain activity after heel lancing. Secondary outcome measures assessed physiological stability and safety. …”

Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial by Hartley, C, Moultrie, FA, Hoskin, A, Green, G, Monk, V, Bell, JL, King, AR, Buckle, M, Van Der Vaart, ML, Gursul, D, Goksan, S, Juszczak, ER, Norman, J, Rogers, R, Patel, CK, Adams, E, Slater, RLEA

“…The co-primary outcomes were the Premature Infant Pain Profile-Revised (PIPP-R) score after ROP screening and the magnitude of noxious-evoked brain activity following heel lancing. Secondary outcomes assessed physiological stability and safety. …”

fMRI reveals neural activity overlap between adult and infant pain by Goksan, S, Hartley, C, Clare, S, Jenkinson, M, Tracey, I, Slater, R, Emery, F, Cockrill, N, Poorun, R, Moultrie, F, Rogers, R, Campbell, J, Sanders, M, Adams, E

“…Significant infant brain activity was observed in 18 of the 20 active adult brain regions but not in the infant amygdala or orbitofrontal cortex. …”

Optimal echo time for functional MRI of the infant brain identified in response to noxious stimulation by Goksan, S, Hartley, C, Hurley, S, Winkler, A, Duff, E, Jenkinson, M, Rogers, R, Clare, S, Slater, R

“…<strong>Purpose:</strong> Blood oxygen level dependent (BOLD) brain activity, measured using functional MRI (fMRI), is dependent on the echo time (TE) and the reversible spin–spin relaxation time constant (T! …”