The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo. by Lucas, A, Chadwick, N, Warren, B, Jewell, D, Gordon, S, Powrie, F, Greaves, D

“…Its unique CX(3)C chemokine domain is attached to a 241-amino acid mucin stalk, a 19-amino acid transmembrane domain, and a 37-amino acid intracellular domain of unknown function. …”

Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activate... by Stacey, M, Lin, H, Hilyard, K, Gordon, S, McKnight, A

“…Two alternative splice forms have been isolated: one encoding a 652-amino acid cell surface protein consisting of two EGF-like domains, a mucin stalk, and a putative G-protein-coupled receptor domain and the other encoding a truncated soluble form containing only two EGF-like domains. …”

Adhesion-GPCRs: emerging roles for novel receptors. by Yona, S, Lin, H, Siu, W, Gordon, S, Stacey, M

“…All members of this family contain a large extracellular region, often containing common protein modules, coupled to a seven-transmembrane domain via a stalk region that seems to be crucial for functionality. …”

Expression of functionally different dectin-1 isoforms by murine macrophages. by Heinsbroek, SE, Taylor, P, Rosas, M, Willment, J, Williams, D, Gordon, S, Brown, G

“…It is a type II membrane receptor that has a C-terminal, NK-like, C-type lectin-like domain separated from the cell membrane by a short stalk region and a cytoplasmic immunoreceptor tyrosine-based activation-like motif. …”

EMR4, a novel epidermal growth factor (EGF)-TM7 molecule up-regulated in activated mouse macrophages, binds to a putative cellular ligand on B lymphoma cell line A20. by Stacey, M, Chang, G, Sanos, S, Chittenden, L, Stubbs, L, Gordon, S, Lin, H

“…Similarly, mEMR4 is over-expressed in TNF-alpha-treated resident peritoneal macrophages, whereas interleukin-4 and -10 dramatically reduce the expression. mEMR4 was found to undergo proteolytic processing within the extracellular stalk region resulting in two protein subunits associated noncovalently as a heterodimer. …”