Palladium-catalyzed allylic fluorination. by Hollingworth, C, Hazari, A, Hopkinson, M, Tredwell, M, Benedetto, E, Huiban, M, Gee, A, Brown, J, Gouverneur, V

Palladium catalyzed allylic fluorination by Hollingworth, C, Brown, J, Gouverneur, V

Palladium mediated allylic fluorination by Hollingworth, C

“…<p>In this thesis, the construction of the allylic fluorides under palladium catalysis was investigated.</p> <p>Chapter 1 provides a general introduction to organofluorine compounds and the use of palladium for the formation of both Csp²- and Csp³-F bonds. …”

Palladium-catalyzed substitution of allylic fluorides. by Hazari, A, Gouverneur, V, Brown, J

“…As unusual substrates for the Tsuji-Trost allylation reaction, allylic fluorides are responsive to palladium-catalyzed substitution. Their activity towards this reaction fits in the series OCO(2)Me&gt;OBz&gt;&gt;F&gt;&gt;OAc. …”

Palladium-catalyzed substitution and cross-coupling of benzylic fluorides. by Blessley, G, Holden, P, Walker, M, Brown, J, Gouverneur, V

Palladium-catalyzed oxidative cyclizations: synthesis of dihydropyranones and furanones. by Reiter, M, Turner, H, Mills-Webb, R, Gouverneur, V

cis-Specific hydrofluorination of alkenylarenes under palladium catalysis through an ionic pathway. by Emer, E, Pfeifer, L, Brown, J, Gouverneur, V

“…This paper describes the hydrofluorination of alkenes through sequential H(-) and F(+) addition under palladium catalysis. The reaction is cis specific, thus providing access to benzylic fluorides. …”

Synthesis of fluorinated alkyl aryl ethers by palladium-catalyzed C–O cross-coupling by Szpera, R, Isenegger, PG, Ghosez, M, Straathof, NJW, Cookson, R, Blakemore, DC, Richardson, P, Gouverneur, V

Oxidative cyclization of beta-hydroxyenones with palladium(II): a novel entry to 2,3-dihydro-4H-pyran-4-ones. by Reiter, M, Ropp, S, Gouverneur, V

“…[reaction: see text] A palladium(II)-mediated oxidative cyclization was found to be effective for the preparation of structurally diverse 2,3-dihydro-4H-pyran-4-ones from the corresponding beta-hydroxyenones. …”

Highly diastereoselective synthesis of trifluoromethyl indolines by interceptive benzylic decarboxylative cycloaddition of nonvinyl, trifluoromethyl benzoxazinanones with sulfur ylides under palladium catalysis by Punna, N, Das, P, Gouverneur, V, Shibata, N

“…The palladium-π-benzyl zwitterionic intermediates are suggested for this transformation, and this would be the first example of an IDBC reaction.…”

I. Ligand-accelerated catalysis in palladium(II)-mediated carbon–hydrogen bond functionalisation, II.... by Engle, K

“…<p>Part I: "Ligand-Accelerated Catalysis in Palladium(II)-Mediated C–H Funtionalisation."</p><p>A lingering problem in the area of Pd(II)-catalysed C–H functionalisation is the dearth of suitable ligands capable of lowering the activation energy for C–H cleavage. …”

A catalytic asymmetric bioorganic route to enantioenriched tetrahydro- and dihydropyranones. by Baker-Glenn, C, Hodnett, N, Reiter, M, Ropp, S, Ancliff, R, Gouverneur, V

“…An attractive feature of this methodology is the possibility to convert these acyclic-enantioenriched beta-hydroxyenones into tetrahydropyranones by a conventional Michael-type addition procedure or into the corresponding dihydropyranones using an alternative palladium-catalyzed oxidative ring closure. For the palladium-mediated cyclization, a biphasic system has been implemented that allows the direct preparation of enantiopure dihydropyranones from the corresponding racemic aldol precursors using a sequential antibody-resolution/palladium-cyclization strategy, without isolation of the intermediate enantioenriched hydroxyenones. …”

Synthesis and reactivity of allylic fluorides under transition metal catalysis by Benedetto, E

“…</p><p>In Chapter 2, an investigation on the reactivity of allylic fluorides, under platinum and palladium catalysed alkylation conditions, is presented. …”

Intramolecular hetero-Michael addition of beta-hydroxyenones for the preparation of highly substituted tetrahydropyranones. by Reiter, M, Turner, H, Gouverneur, V

“…The use of [Pd(MeCN)(4)](BF(4))(2) is particularly effective, as this palladium-mediated reaction is under kinetic control and generates tri- and tetrasubstituted tetrahydropyranones with high levels of diastereocontrol. …”

Transition metal catalysis in the presence of fluorinating reagents by Hopkinson, M

“…</p><p>In Chapter 5, the feasibility of palladium-catalysed allylic [¹⁸F]radiofluorination was investigated using high-specific-activity [¹⁸F]fluoride. …”

Catalytic activation of hydrogen, silicon, and fluorine by transition-metal complexes by Rauf, W, Hazari, A, Gouverneur, V, Brown, J

“…The remarkable versatility of palladium catalysis is exemplified by recent work in two distinct areas. …”

Pd(II)-catalyzed cascade Wacker-Heck reaction: chemoselective coupling of two electron-deficient reactants. by Silva, F, Reiter, M, Mills-Webb, R, Sawicki, M, Klär, D, Bensel, N, Wagner, A, Gouverneur, V

“…A novel palladium(II)-catalyzed oxy-carbopalladation process was developed allowing for the orchestrated union of hydroxy ynones with ethyl acrylate, two electron-deficient reactants. …”

Synthesis of a novel diarylphosphinic acid: a distorted ground state mimic and transition state analogue for amide hydrolysis by Schuman, M, Lopez, X, Karplus, M, Gouverneur, V

“…This hapten along with a series of new sterically hindered unsymmetrical phosphinic acid derivatives was prepared by a key palladium-catalysed step. © 2001 Elsevier Science Ltd. …”

Catalytic enantioselective synthesis of P-stereogenic compounds. by Harvey, J, Gouverneur, V

“…The dynamic kinetic resolution of racemic P-templates relying on a P-C bond-forming event has been the object of extensive investigations, which have culminated with the arylation and alkylation (benzylation) of equilibrating diastereomeric palladium, platinum or ruthenium phosphido complexes. …”

The fluorination of C–H bonds: developments and perspectives by Gouverneur, V, Szpera, R, Moseley, D, Smith, L, Sterling, A

“…Transition metal catalyzed approaches championed by palladium have allowed the installation of a fluorine substituent at C(sp2) and C(sp3) sites exploiting the reactivity of high oxidation transition metal fluoride complexes combined with the use of directing group (some transient) to control regio‐ and stereoselectivity. …”