A single sleeping midnight cortisol has 100% sensitivity for the diagnosis of Cushing's syndrome. by Newell-Price, J, Trainer, P, Perry, L, Wass, J, Grossman, A, Besser, M

“…RESULTS: In all the control subjects the sleeping midnight cortisol was < 50 nmol/l, below the lowest standard of the routine in-house RIA. …”

The investigation of Cushing syndrome: essentials in optimizing appropriate diagnosis and management. by Juszczak, A, Grossman, A

“…The recommended first-line tests include midnight salivary cortisol and/or the 1 mg overnight or low-dose dexamethasone suppression tests. …”

Diurnal variation in the effect of melatonin on neurohypophysial hormone release from the rat hypothalamus. by Yasin, SA, Grossman, A, Forsling, M

“…Basal release of hormone was not influenced by the time of day when the animals were taken, although stimulated release was elevated at midnight. In groups A and B both doses of melatonin significantly reduced basal and stimulated release of vasopressin and basal release of oxytocin (p < 0.01), although no effect was seen in group C animals. …”

The management of Cushing's disease - from investigation to treatment. by Juszczak, A, Grossman, A

“…If the initial test is positive on two occasions, the patient should be referred to a specialist endocrinologist for in-patient assessment, while elevated midnight serum cortisol and a low dose dexamethasone suppression test will confirm endogenous hypercortisolaemia. …”

Continuous administration of human corticotropin-releasing hormone in the absence of glucocorticoid feedback in man. by Ur, E, Capstick, C, McLoughlin, L, Checkley, S, Besser, G, Grossman, A

“…Circadian rhythm of ACTH was maintained, with a fall in the evening to 14.5 +/- 4 pg/ml (mean +/- SE) at midnight and an exaggerated rise overnight, reaching a peak level of 90 +/- 33 pg/ml at 07:00 h. …”