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    Fungal gut microbiota dysbiosis in systemic lupus erythematosus by Ping Yang, Rui Xu, Fei Chen, Shanshan Chen, Adeel Khan, Liang Li, Xiaoshan Zhang, Yanbo Wang, Zhipeng Xu, Han Shen

    Published 2023-04-01
    “…The mycobiome: which is a small but crucial part of the gut microbiota and is involved in hosts’ homeostasis and physiological processes, remained unexplored in SLE.MethodsWe profiled the gut fungal mycobiota based on internal transcribed spacer region 1 (ITS1) sequencing for the gut microbial DNA from the SLE individuals with lupus nephritis (LN) (n = 23), SLE without LN (n = 26) and healthy controls (n = 14) enrolled in Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School.ResultsThe ITS sequencing generated a total of 4.63 million valid tags which were stratified into 4,488 operational taxonomic units (OTUs) and identified about 13 phyla and 262 genera. …”
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