Elective Freezing of embryos versus Fresh embryo transfer in In-vitro fertilisation – a multicentre randomised controlled trial in the UK (E-Freeze) by Maheshwari, A, Bell, JL, Bhide, P, Cole, C, Hardy, P, Juszczak, E, Kurinczuk, J, Linsell, L, Stanbury, K

“…R.M. reports consulting fees from Gedeon Richter, honorarium from Merck, support fees for attendance at educational events and conferences for Merck, Ferring, Bessins and Gedeon Richter, payments for participation on a Merck Safety or Advisory Board, Chair of the British Fertility Society and payments for an advisory role to the Human Fertilisation and Embryology Authority. G.S. reports travel and accommodation fees for attendance at a health economic advisory board from Merck KGaA, Darmstadt, Germany. …”

E-Freeze - a randomised controlled trial evaluating the clinical and cost effectiveness of a policy of freezing embryos followed by thawed frozen embryo transfer compared with a policy of fresh embryo transfer, in women undergoing in vitro fertilisation: a statistical analysis plan by Bell, JL, Hardy, P, Greenland, M, Juszczak, E, Cole, C, Maheshwari, A, Bhattacharya, S, Linsell, L

“…BACKGROUND:The E-Freeze trial is a multi-centre randomised controlled trial of fresh versus frozen embryo transfer for women undergoing in vitro fertilisation. This paper describes the statistical analysis plan for the E-Freeze trial. …”

Study protocol: E-freeze - freezing of embryos in assisted conception: a randomised controlled trial evaluating the clinical and cost effectiveness of a policy of freezing embryos followed by thawed frozen embryo transfer compared with a policy of fresh embryo transfer, in women undergoing in vitro fertilisation by Maheshwari, A, Bhattacharya, S, Bowler, U, Brison, D, Child, T, Cole, C, Coomarasamy, A, Cutting, R, Harbottle, S, Hardy, P, Juszczak, E, Khalaf, Y, Kurinczuk, J, Lavery, S, Lewis-Jones, C, Macklon, N, Raine-Fenning, N, Rajkohwa, M, Scotland, G, Troup, S

“…BACKGROUND:Infertility affects one in seven couples; many of these need in vitro fertilisation (IVF). IVF involves external hormones to stimulate a woman's ovaries to produce eggs which are harvested surgically. …”

Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF: the E-Freeze RCT by Maheshwari, A, Bari, V, Bell, JL, Bhattacharya, S, Bhide, P, Bowler, U, Brison, D, Child, T, Chong, HY, Cheong, Y, Cole, C, Coomarasamy, A, Cutting, R, Goodgame, F, Hardy, P, Hamoda, H, Juszczak, E, Khalaf, Y, King, A, Kurinczuk, JJ, Lavery, S, Lewis-Jones, C, Linsell, L, Macklon, N, Mathur, R, Murray, D, Pundir, J, Raine-Fenning, N, Rajkohwa, M, Robinson, L, Scotland, G, Stanbury, K, Troup, S

“…<br><strong> Setting<br></strong> Eighteen in vitro fertilisation clinics across the UK participated from February 2016 to April 2019. …”

Individual participant data meta-analysis of trials comparing frozen versus fresh embryo transfer strategy (INFORM) - a protocol by Wang, R, McLernon, DJ, Lai, S, Hardy, P

“…A freeze-all or a fresh transfer policy may be preferable for some couples undergoing in-vitro fertilisation (IVF), but it is unclear which couples would benefit most from each policy, how and under which protocols. …”