Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo by Nikolaou, N, Arvaniti, A, Appanna, N, Sharp, A, Hughes, B, Digweed, D, Whitaker, M, Ross, RJ, Arlt, W, Penning, T, Morris, K, George, S, Keevil, B, Hodson, L, Gathercole, L, Tomlinson, JW

“…Steroid 5β-reductase (AKR1D1) is highly expressed in human liver where it inactivates endogenous glucocorticoids and catalyses an important step in bile acid synthesis. …”

Saturated fat is more metabolically harmful for the human liver than unsaturated fat or simple sugars by Luukkonen, P, Sädevirta, S, Zhou, Y, Kayser, B, Ali, A, Ahonen, L, Lallukka, S, Pelloux, V, Gaggini, M, Jian, C, Hakkarainen, A, Lundbom, N, Gylling, H, Salonen, A, Orešič, M, Hyötyläinen, T, Orho-Melander, M, Rissanen, A, Gastaldelli, A, Clément, K, Hodson, L, Yki-Järvinen, H

A study of hepatocyte ischaemia-reperfusion injury and steatosis in a human liver stem cell model by Sivathondan, P, Hodson, L, Dragovic, R, Silva, M, Friend, P, Morten, K

Detection and alterations of acetylcarnitine (AC) in human liver by 1H MRS at 3T after supplementation with L-carnitine by Savic, D, Mózes, FE, Green, PG, Burrage, MK, Kjaer, MS, Hodson, L, Neubauer, S, Pavlides, M, Valkovič, L

AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease. by Nikolaou, N, Gathercole, L, Marchand, L, Althari, S, Dempster, N, Green, C, Van De Bunt, M, McNeil, C, Arvaniti, A, Hughes, B, Sgromo, B, Gillies, R, Marschall, H, Penning, T, Ryan, J, Arlt, W, Hodson, L, Tomlinson, J

“…Steroid 5β-reductase (AKR1D1) is highly expressed in human liver where it inactivates steroid hormones and catalyzes a fundamental step in bile acid synthesis.…”

The isolation of primary hepatocytes from human tissue: optimising the use of small non-encapsulated liver resection surplus by Green, C, Charlton, C, Wang, L, Silva, M, Morten, K, Hodson, L

“…Therefore, the aim of this work was to develop an alternative method to isolate hepatocytes from non-encapsulated and small samples of human liver tissue. Healthy tissue from 44 human liver resections were graded for steatosis and tissue weights between 7.8 and 600 g were used for hepatocyte isolations. …”

Unravelling the role of AKR1D1 in human hepatocytes by Nikolaou, N

“…Steroid 5β-reductase (AKR1D1) is highly expressed in human liver where it inactivates steroid hormones and catalyses a fundamental step in bile acid synthesis. …”

Hepatic fatty acid partitioning. by Hodson, L, Frayn, K

“…These studies highlight our lack of understanding of the regulation of metabolic partitioning of fatty acids within the human liver. SUMMARY: The regulation of hepatic fatty acid partitioning involves many factors; not least insulin. …”

Hepatic fatty acid partitioning by Hodson, L, Frayn, K

“…These studies highlight our lack of understanding of the regulation of metabolic partitioning of fatty acids within the human liver. Summary: The regulation of hepatic fatty acid partitioning involves many factors; not least insulin. …”

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity by Vriens, K, Christen, S, Parik, S, Broekaert, D, Yoshinaga, K, Talebi, A, Dehairs, J, Escalona-Noguero, C, Schmieder, R, Cornfield, T, Charlton, C, Romero-Pérez, L, Rossi, M, Rinaldi, G, Orth, M, Boon, R, Kerstens, A, Kwan, S, Faubert, B, Méndez-Lucas, A, Kopitz, C, Chen, T, Fernandez-Garcia, J, Duarte, J, Schmitz, A, Steigemann, P, Najimi, M, Hägebarth, A, Van Ginderachter, J, Sokal, E, Gotoh, N, Wong, K, Verfaillie, C, Derua, R, Munck, S, Yuneva, M, Beretta, L, Deberardinis, R, Swinnen, J, Hodson, L, Cassiman, D, Verslype, C, Christian, S, Grünewald, S, Grünewald, T, Fendt, S

“…We identify various cancer cell lines, mouse hepatocellular carcinomas, and primary human liver and lung carcinomas that desaturate palmitate to the unusual fatty acid sapienate to support membrane biosynthesis during proliferation. …”

Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids by Luukkonen, PK, Nick, A, Hölttä-Vuori, M, Thiele, C, Isokuortti, E, Lallukka-Brück, S, Zhou, Y, Hakkarainen, A, Lundbom, N, Peltonen, M, Orho-Melander, M, Orešič, M, Hyötyläinen, T, Hodson, L, Ikonen, E, Yki-Järvinen, H

“…Polyunsaturated TGs were increased, while phosphatidylcholines (PCs) were decreased in the human liver in 148M homozygous individuals as compared with 148I homozygotes. …”

Hepatic de novo lipogenesis is suppressed and fat oxidation is increased by omega-3 fatty acids at the expense of glucose metabolism by Green, C, Pramfalk, C, Charlton, C, Gunn, P, Cornfield, T, Pavlides, M, Karpe, F, Hodson, L

“…In vitro studies, using a human liver cell-line were undertaken to gain insight into the intra-hepatocellular effects of omega-3 FAs.…”

Defatting of donor transplant livers during normothermic perfusion - a randomised clinical trial: study protocol for the DeFat study by Abbas, SH, Ceresa, CDL, Hodson, L, Coussios, C, Kounali, D, Knight, S, Friend, P

“…We have recently tested defatting interventions during normothermic machine perfusion (NMP) in discarded steatotic human livers that were not transplanted. A combination of therapies including forskolin (NKH477) and L-carnitine to defat liver cells and lipoprotein apheresis filtration were investigated. …”