Neuroimaging of rapid eye movement sleep behavior disorder by Bourouin, P, Rahayel, S, Gaubert, M, Hu, M, Gagnon, J

“…Idiopathic rapid eye movement sleep behavior disorder (iRBD) is a parasomnia characterized by the loss of muscle atonia and the presence of undesirable motor manifestations during rapid eye movement sleep. …”

Apathy in rapid eye movement sleep behaviour disorder is common and under-recognized. by Barber, T, Muhammed, K, Drew, D, Lawton, M, Crabbe, M, Rolinski, M, Quinnell, T, Zaiwalla, Z, Ben-Shlomo, Y, Husain, M, Hu, M

“…Patients with rapid eye movement sleep behaviour disorder (RBD) have a high probability of developing Parkinson’s disease in future. …”

Clinical and neuroimaging markers of prodromal neurodegeneration in rapid eye movement sleep behaviour disorder by Barber, TR

“…<p>Patients with rapid eye movement sleep behaviour disorder (RBD) have a high long-term risk of developing Parkinson’s disease or a related synucleinopathy. …”

Full sequencing and haplotype analysis of MAPT in Parkinson's disease and rapid eye movement sleep behavior disorder by Li, J, Ruskey, J, Arnulf, I, Dauvilliers, Y, Hu, M, Högl, B, Leblond, C, Zhou, S, Ambalavanan, A, Ross, J, Bourassa, C, Spiegelman, D, Laurent, S, Stefani, A, Charley Monaca, C, Cochen De Cock, V, Boivin, M, Ferini-Strambi, L, Plazzi, G, Antelmi, E, Young, P, Heidbreder, A, Labbe, C, Ferman, T, Dion, P, Fan, D, Desautels, A, Gagnon, J, Dupré, N, Fon, E, Montplaisir, J, Boeve, B, Postuma, R, Rouleau, G, Ross, O, Gan-Or, Z

“…<p><strong>Background:</strong> MAPT haplotypes are associated with PD, but their association with rapid eye movement sleep behavior disorder is unclear.</p> <p><strong>Objective:</strong> To study the role of MAPT variants in rapid eye movement sleep behavior disorder.…”

The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder by Gan-Or, Z, Montplaisir, J, Ross, J, Poirier, J, Warby, S, Arnulf, I, Strong, S, Dauvilliers, Y, Leblond, C, Hu, M, Högl, B, Stefani, A, Monaca, C, De Cock, V, Boivin, M, Ferini-Strambi, L, Plazzi, G, Antelmi, E, Young, P, Heidbreder, A, Barber, T, Evetts, S, Rolinski, M, Dion, P, Desautels, A, Gagnon, J, Dupré, N, Postuma, R, Rouleau, G

“…The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). …”

Smartphone speech testing for symptom assessment in rapid eye movement sleep behavior disorder and Parkinson's disease by Arora, S, Lo, C, Hu, M, Tsanas, A

“…It is known that isolated Rapid Eye Movement (REM) sleep Behavior Disorder (RBD) is associated with a high risk of developing PD. …”

A data driven approach towards understanding deficits in olfactory and motor function and identifying applications of smartphone motor testing in prodromal and manifest Parkinson’s... by Lo, C

Subjects: “…Rapid eye movement sleep…”

Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson’s disease by Rolinski, M, Griffanti, L, Piccini, P, Roussakis, A, Szewczyk-Krolikowski1, K, Menke, R, Quinnell, T, Zaiwalla, Z, Klein, J, Mackay, C, Hu, M

“…Currently, it is unclear whether these changes are present in so-called idiopathic rapid eye movement sleep behaviour disorder, a condition associated with a high rate of future conversion to Parkinson’s disease. …”

Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells by Smith, A, Depp, C, Ryan, B, Johnston, G, Alegre-Abarrategui, J, Evetts, S, Rolinski, M, Baig, F, Ruffmann, C, Simon, A, Hu, M, Wade-Martins, R

“…To investigate disease processes in accessible patient cells, we studied peripheral blood mononuclear cells in recently diagnosed PD patients and rapid eye movement‐sleep behavior disorder patients who have a greatly increased risk of developing PD. …”

Reward sensitivity deficits underlie apathy in Parkinson's disease by Muhammed, K, Manohar, S, Tofaris, G, Lennox, G, Bogdanovic, M, Hu, M, Husain, M

“…The mechanisms underlying the condition are poorly understood and objective detection methods are lacking. We used eye movement and pupil modulation in response to rewards as metrics of motivation to assess the relation of reward sensitivity to apathy and influence of dopaminergic medication.…”

Detection of REM sleep behaviour disorder by automated polysomnography analysis by Cooray, N, Andreotti, F, Lo, C, Symmonds, M, Hu, M, De Vos, M

“…<p><strong>Objective</strong> Evidence suggests Rapid-Eye-Movement (REM) Sleep Behaviour Disorder (RBD) is an early predictor of Parkinson’s disease. …”

Predicting motor, cognitive and functional impairment in Parkinson's by Lo, C, Arora, S, Baig, F, Lawton, M, El Mouden, C, Barber, T, Ruffmann, C, Klein, J, Brown, P, Ben‐Shlomo, Y, Vos, M, Hu, M

“…<strong>Objective</strong> We recently demonstrated that 998 features derived from a simple 7‐minute smartphone test could distinguish between controls, people with Parkinson's and people with idiopathic Rapid Eye Movement sleep behavior disorder, with mean sensitivity/specificity values of 84.6‐91.9%. …”

LRRK2 protective haplotype and full sequencing study in REM sleep behavior disorder by Ouled Amar Bencheikh, B, Ruskey, J, Arnulf, I, Dauvilliers, Y, Monaca, C, Cock, D, Gagnon, J, Spiegelman, D, Hu, M, Högl, B, Stefani, A, Ferini-Strambi, L, Plazzi, G, Antelmi, E, Young, P, Heidbreder, A, Mollenhauer, B, Sixel-Döring, F, Trenkwalder, C, Oertel, W, Montplaisir, J, Postuma, R, Rouleau, G, Gan-Or, Z

“…<br/><strong>Background: </strong>Individuals with rapid eye movement (REM)-sleep behavior disorder (RBD) are likely to progress to synucleinopathies, mainly Parkinson's disease (PD), dementia with Lewy-bodies (DLB) and multiple system atrophy (MSA). …”

Personality and addictive behaviours in early Parkinson's disease and REM sleep behaviour disorder by Baig, F, Lawton, M, Rolinski, M, Ruffmann, C, Klein, J, Nithi, K, Okai, D, Ben-Shlomo, Y, Hu, M

“…</p> <h4>Methods</h4> <p>941 population-ascertained PD subjects within 3.5 years of diagnosis, 128 patients with rapid eye movement sleep behaviour disorder (RBD) and 292 control subjects were fully characterised for motor symptoms, non-motor symptoms and across the following 5 personality domains: 1) neuroticism 2) extraversion 3) conscientiousness 4) agreeableness 5) openness using the Big Five Inventory.…”

GBA variants in REM sleep behavior disorder: A multicenter study by Krohn, L, Ruskey, JA, Rudakou, U, Hu, M

“…<p><strong>Objective:</strong><br /> To study the role of GBA variants in the risk for isolated rapid-eye-movement (REM)-sleep behavior disorder (iRBD) and conversion to overt neurodegeneration.…”

Cohort profile: the Oxford Parkinson’s Disease Centre Discovery Cohort MRI substudy (OPDC-MRI) by Griffanti, L, Klein, JC, Szewczyk-Krolikowski, K, Menke, R, Rolinski, M, Barber, T, Lawton, M, Evetts, S, Begeti, F, Crabbe, M, Rumbold, J, Wade-Martins, R, Hu, M, Mackay, C

“…Baseline MRI data are currently available for 290 participants: 119 patients with early idiopathic Parkinson’s, 15 Parkinson’s patients with pathogenic mutations of the leucine-rich repeat kinase 2 or glucocerebrosidase (GBA) genes, 68 healthy controls and 87 individuals at risk of Parkinson’s (asymptomatic carriers of GBA mutation and patients with idiopathic rapid eye movement sleep behaviour disorder-RBD).</p> <p><strong>Findings to date:</strong> Differences in brain structure in early Parkinson’s were found to be subtle, with small changes in the shape of the globus pallidus and evidence of alterations in microstructural integrity in the prefrontal cortex that correlated with performance on executive function tests. …”

Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson’s disease by Rolinski, M, Griffanti, L, Piccini, P, Roussakis, A, Szewczyk-Krolikowski, K, Menke, R, Quinnell, T, Zaiwalla, Z, Klein, J, Mackay, C, Hu, M

“…Currently, it is unclear whether these changes are present in so-called idiopathic rapid eye movement sleep behaviour disorder (RBD), a condition associated with a high rate of future conversion to Parkinson’s. …”