A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies by Frederic Bibollet-Ruche, Ronnie M. Russell, Wenge Ding, Weimin Liu, Yingying Li, Kshitij Wagh, Daniel Wrapp, Rumi Habib, Ashwin N. Skelly, Ryan S. Roark, Scott Sherrill-Mix, Shuyi Wang, Juliette Rando, Emily Lindemuth, Kendra Cruickshank, Younghoon Park, Rachel Baum, John W. Carey, Andrew Jesse Connell, Hui Li, Elena E. Giorgi, Ge S. Song, Shilei Ding, Andrés Finzi, Amanda Newman, Giovanna E. Hernandez, Emily Machiele, Derek W. Cain, Katayoun Mansouri, Mark G. Lewis, David C. Montefiori, Kevin J. Wiehe, S. Munir Alam, I-Ting Teng, Peter D. Kwong, Raiees Andrabi, Laurent Verkoczy, Dennis R. Burton, Bette T. Korber, Kevin O. Saunders, Barton F. Haynes, Robert J. Edwards, George M. Shaw, Beatrice H. Hahn

“…Trimer immunization of knock-in mice induced V2-directed NAbs, indicating activation of V2-apex bNAb precursor-expressing mouse B cells. …”
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PtrDJ1C, an atypical member of the DJ-1 superfamily, is essential for early chloroplast development and lignin deposition in poplar by Xinwei Wang, Chunxue Shao, Libo Liu, Yue Wang, Yaqi An, Hui Li, Yunwei Ding, Yanping Jing, Xiaojuan Li, Jianwei Xiao

“…This study reports the Populus trichocarpa DJ-1C (PtrDJ1C) factor, encoded by a nuclear gene, and a member of the DJ-1 superfamily. PtrDJ1C knock-out with the CRISPR/Cas9 system resulted in different albino phenotypes. …”
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MsmR1, a global transcription factor, regulates polymyxin synthesis and carbohydrate metabolism in Paenibacillus polymyxa SC2 by Dongying Zhao, Hui Li, Yanru Cui, Shengyue Tang, Chengqiang Wang, Binghai Du, Yanqin Ding

“…However, the transcriptional regulatory mechanisms of MsmR1 in Paenibacillus polymyxa remain unclear. In this study, knocking out msmR1 was found to reduce polymyxin synthesis by the SC2-M1 strain. …”
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MACF1 overexpression in BMSCs alleviates senile osteoporosis in mice through TCF4/miR-335–5p signaling pathway by Kewen Zhang, Wuxia Qiu, Hui Li, Jun Li, Pai Wang, Zhihao Chen, Xiao Lin, Airong Qian

“…Methods: We established MSC-specific Prrx1 (Prx1) promoter-driven MACF1 conditional knock-in (MACF-KI) mice, naturally aged male mice, and ovariectomized female mice models. …”
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Nrf2 pathway regulates multidrug-resistance-associated protein 1 in small cell lung cancer. by Lili Ji, Hui Li, Pan Gao, Guoguo Shang, Donna D Zhang, Nong Zhang, Tao Jiang

“…Compared with H69 lung cancer cells, H69AR cells with MDR showed significantly higher Nrf2-ARE pathway activity and expression of Mrp1 as well. When Nrf2 was knocked down in H69AR cells, MRP1's expression decreased accordingly. …”
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MiR-1286 inhibits lung cancer growth through aerobic glycolysis by targeting PKM2 by Hui Li, Xuexia Lin, Chaopeng Li, Jungai Li, Xunxun Xu, Dongyue Meng, Shushen Zheng

“…Material and methods The mRNA levels of miR-1286 in NSCLC tissues and mouse tumor tissues were detected by q-PCR. MiR-1286 was knocked down and overexpressed separately in A549 cells. …”
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CHEK2 knockout is a therapeutic target for TP53-mutated hepatocellular carcinoma by Yuyan Chen, Zhengyi Zhu, Xingyu Wu, Hui Li, Wenxian Guan, Haozhen Ren

“…Subsequently, the results indicated that knocking out CHEK2 selectively affects the proliferation, cell cycle, senescence, and apoptosis of TP53-mutant HCC cells. …”
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Rictor maintains endothelial integrity under shear stress by Hui Li, Wen-Ying Zhou, Yi-Xian Liu, Yi-Yuan Xia, Chun-Lei Xia, Dao-Rong Pan, Zheng Li, Yi Shi, Shao-Liang Chen, Jun-Xia Zhang

“…However, the impact of conditional Rictor ablation on endothelial homeostasis, especially on endothelial-specific markers, such as vascular endothelial-cadherin (VE-cadherin) and von Willebrand factor (VWF), under blood flow stimulation is unclear.Objective: We aimed to investigate whether endothelial Rictor is involved in maintaining vascular endothelial integrity and the potential role of Rictor in atheroprone blood flow-mediated endothelial injury.Methods and results: Immunofluorescence staining showed that endothelial Rictor was successfully knocked out in a mouse model. Scanning electron microscopy (EM) detection revealed disruption of the endothelial monolayer in the thoracic aorta of Rictor-deficient mice. …”
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miR-29b-3p regulates cardiomyocytes pyroptosis in CVB3-induced myocarditis through targeting DNMT3A by Ya Wang, Zhengyang Zhang, Hui Li, Min Wang, Yuting Qiu, Lili Lu

“…To explore the function of miR-29b-3p in CVB3-induced VMC, we conducted in vivo experiments by knocking down the expression of miR-29b-3p using antagomir. …”
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Aerobic Exercise Inhibited P2X7 Purinergic Receptors to Improve Cardiac Remodeling in Mice With Type 2 Diabetes by Ting Wang, Jianmin Li, Hui Li, Xin Zhong, Luya Wang, Shujue Zhao, Xuesheng Liu, Zhouqing Huang, Yonghua Wang

“…Moreover, we indicated that P2X7R knock out significantly reduced the collagen deposition and disordered cells in the DM group. …”
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