A novel hACE2 knock-in mouse model recapitulates pulmonary and intestinal SARS-CoV-2 infection by Xiaoyang Zhou, Weiyang Sun, Yu Zhang, Hongjing Gu, Ruixuan Wang, Peng Xie, Yunkai Zhu, Minyue Qiu, Xiaoyan Ding, Hui Wang, Yuwei Gao, Jintao Li

“…In this study, a novel human ACE2 knock-in (KI) mouse model (or hACE2-KI) was systemically compared with the popular K18-hACE2 mice; it showed differences in the distribution of lung and intestinal infections and pathophysiological characteristics. …”
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PIBF1 regulates multiple gene expression via impeding long-range chromatin interaction to drive the malignant transformation of HPV16 integration epithelial cells by Xiaomin Li, Ci Ren, Anni Huang, Yue Zhao, Liming Wang, Hui Shen, Chun Gao, Bingxin Chen, Tong Zhu, Jinfeng Xiong, Da Zhu, Yafei Huang, Jianlin Ding, Zan Yuan, Wencheng Ding, Hui Wang

“…Objectives: We established a 13q22 site-specific HPV16 gene knock-in cell model to interrogate the changes in chromatin structure at the initial stages of host cell malignant transformation. …”
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Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB–P300–BRD4 axis by Xuesong Li, Ruigong Zhu, Hong Jiang, Quanwen Yin, Jiaming Gu, Jiajing Chen, Xian Ji, Xuan Wu, Haiping Fu, Hui Wang, Xin Tang, Yuanqing Gao, Bingjian Wang, Yong Ji, Hongshan Chen

“…Furthermore, the anti-atherogenesis effect of Cur was inhibited by macrophage-specific Brd4 overexpression or Tfeb knock-out in Apoe knock-out mice via bone marrow transplantation. …”
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Regulatory role of PI16 in autoimmune arthritis and intestinal inflammation: implications for Treg cell differentiation and function by Yuankai Sun, Shiyu Lin, Hui Wang, Lei Wang, Yulu Qiu, Feifei Zhang, Nannan Hao, Fang Wang, Wenfeng Tan

“…Our findings demonstrate that conditional knock-out of PI16 in Tregs significantly enhances their differentiation and suppressive functions. …”
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Long non-coding RNA DUXAP8 promotes the cell proliferation, migration, and invasion of papillary thyroid carcinoma via miR-223-3p mediated regulation of CXCR4 by Yan Liu, Hejia Zhang, Hui Wang, Jiarui Du, Peng Dong, Meihan Liu, Yuanqiang Lin

“…The expression of DUXAP8 was knocked down in two PTC cell lines and the effects of DUXAP8 on the PTC biological behavior were examined by cell counting kit-8 (CCK-8), wound healing, and transwell invasion assays. …”
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Mesenchymal Stem Cells Derived Extracellular Vesicles Alleviate Traumatic Hemorrhagic Shock Induced Hepatic Injury via IL-10/PTPN22-Mediated M2 Kupffer Cell Polarization by Yunwei Zhang, Xiaofei Zhang, Hongji Zhang, Peng Song, Wenming Pan, Peng Xu, Guoliang Wang, Ping Hu, Zixuan Wang, Kunpeng Huang, Xiaodong Zhang, Hui Wang, Hui Wang, Jinxiang Zhang

“…Notably, these beneficial effects of MSCs disappeared when IL-10 was knocked out in EVs or when recombinant IL-10 was administered to mice. …”
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CXCL2-mediated ATR/CHK1 signaling pathway and platinum resistance in epithelial ovarian cancer by Sipei Nie, Yicong Wan, Hui Wang, Jinhui Liu, Jing Yang, Rui Sun, Huangyang Meng, Xiaolin Ma, Yi Jiang, Wenjun Cheng

“…The functional assays showed overexpressing CXCL2 or co-culturing with recombinant human CXCL2 promoted cell resistance to cisplatin. Conversely, knocking down CXCL2 or co-culturing with neutralizing antibody to CXCL2 increased cell response to cisplatin. …”
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Activation of Liver X Receptor α Sensitizes Mice to T‐Cell Mediated Hepatitis by Li Gao, Bin Li, Jingyuan Wang, Danhua Shen, Min Yang, Runzi Sun, Hung‐Chun Tung, Meishu Xu, Songrong Ren, Min Zhang, Da Yang, Binfeng Lu, Hui Wang, Yulan Liu, Wen Xie

“…In the ConA model, we were surprised to find that activation of LXRα in the constitutively activated VP‐LXRα whole‐body knock‐in (LXRα‐KI) mice exacerbated ConA‐induced AIH, whereas the LXRα−/− mice showed attenuated ConA‐induced AIH. …”
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A dual Ucp1 reporter mouse model for imaging and quantitation of brown and brite fat recruitment by Hui Wang, Monja Willershäuser, Angelos Karlas, Dimitris Gorpas, Josefine Reber, Vasilis Ntziachristos, Stefanie Maurer, Tobias Fromme, Yongguo Li, Martin Klingenspor

“…Methods: We generated a knock-in mouse line expressing firefly luciferase and near-infrared red florescent protein (iRFP713) driven by the regulatory elements of the endogenous Ucp1 gene. …”
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Crosstalk between corepressor NRIP1 and cAMP signaling on adipocyte thermogenic programming by Emmanouela Tsagkaraki, Adilson Guilherme, Sarah M. Nicoloro, Mark Kelly, Lawrence M. Lifshitz, Hui Wang, Kyounghee Min, Leslie A. Rowland, Kaltinaitis B. Santos, Nicole Wetoska, Randall H. Friedline, Stacy A. Maitland, Min Chen, Lee S. Weinstein, Scot A. Wolfe, Jason K. Kim, Michael P. Czech

“…Since β-adrenergic signaling through cAMP strongly promotes adipocyte thermogenesis, we tested whether the effects of NRIP1 knock-out (NRIP1KO) require the cAMP pathway. Methods: NRIP1KO adipocytes were implanted in recipient high-fat diet (HFD) fed mice and metabolic cage studies conducted. …”
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