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How can the typhoid fever surveillance in Africa and the severe typhoid fever in Africa programs contribute to the introduction of typhoid conjugate vaccines?
Published 2019“…Data from the Severe Typhoid Fever in Africa (SETA) program were used to contribute to TCV introduction decision-making processes, exemplified for Ghana and Madagascar. …”
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The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa
Published 2018Journal article -
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Reproducible diagnostic metabolites in plasma from typhoid fever patients in Asia and Africa.
Published 2017“…Here, we performed mass spectrometry on plasma from Bangladeshi and Senegalese patients with culture confirmed typhoid fever, clinically suspected typhoid, and other febrile diseases including malaria. …”
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The monitoring and evaluation of a multicountry surveillance study, the Severe Typhoid Fever in Africa Program
Published 2019“…Here, we describe the monitoring and evaluation procedures created for the multicountry Severe Typhoid Fever in Africa (SETA) study.</p> <p><strong>Methods</strong> Elements from the US Food and Drug Administration (FDA) and European Centre for Disease Prevention and Control (ECDC) recommendations on monitoring clinical trials and data quality, respectively were applied in the development of the SETA monitoring plan. …”
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Occurrence of typhoid fever complications and associated risk factors: A systematic literature review and meta-analysis
Published 2019Conference item -
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Occurrence of typhoid fever complications and their relation to duration of illness preceding hospitalization: A systematic literature review and meta-analysis
Published 2019“…<strong>Background</strong> Complications from typhoid fever disease have been estimated to occur in 10%–15% of hospitalized patients, with evidence of a higher risk in children and when delaying the implementation of effective antimicrobial treatment. …”
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Acute febrile illness among children in Butajira, south–central Ethiopia during the Typhoid Fever Surveillance in Africa Program
Published 2019“…We investigated acute febrile illness in children aged ≤15 years enrolled at healthcare facilities in Butajira, Ethiopia, during January 2012 to January 2014 for the Typhoid Fever Surveillance in Africa Program.</p> <p><strong>Methods</strong> Blood culture, malaria microscopy, and blood analyses followed by microbiological, biochemical, and antimicrobial susceptibility testing of isolates were performed. …”
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Aspects of disease burden and risk factors for bacterial disease in low- and middle-income countries
Published 2021“…Secondly, I developed a clinical definition for typhoid fever that satisfied the criteria of being predictive of culture-confirmed typhoid fever and being protected against by an effective typhoid vaccine. …”
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Incidence of invasive salmonella disease in sub-Saharan Africa: a multicentre population-based surveillance study
Published 2017“…The AIR of iNTS and typhoid fever in individuals younger than 15 years old was typically higher than in those aged 15 years or older. …”
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Prevention of typhoid by Vi conjugate vaccine and achievable improvements in household water, sanitation, and hygiene: evidence from a cluster-randomized trial in Dhaka, Bangladesh
Published 2022“…<p><strong>Background</strong></p> Typhoid fever contributes to approximately 135 000 deaths annually. …”
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Determining the best immunization strategy for protecting African children against invasive Salmonella disease
Published 2018“…<strong>Background</strong> The World Health Organization recently prequalified a typhoid conjugate vaccine (TCV), recommending its use in persons ≥6 months to 45 years residing in typhoid fever (TF)–endemic areas. We now need to consider how TCVs can have the greatest impact in the most vulnerable populations. …”
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The global burden and epidemiology of invasive non-typhoidal Salmonella infections
Published 2018“…The accessibility of whole genome sequencing has allowed for genetic characterization of pathogens, shedding light on its evolutionary history and sounding alerts for its future progression. iNTS disease is observed to be a particular threat in sub-Saharan Africa, with a case fatality rate greatly exceeding that of typhoid fever, and commonly affecting infants, young children and immunocompromised adults. …”
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Multicountry distribution and characterization of extended-spectrum β-lactamase-associated gram-negative bacteria from bloodstream infections in sub-Saharan Africa
Published 2019“…</p> <p><strong>Methods</strong> Data were generated during the Typhoid Fever Surveillance in Africa Program (TSAP), in which standardized blood cultures were performed on febrile patients attending 12 health facilities in 9 sub-Saharan African countries between 2010 and 2014. …”
Journal article