Genetic polymorphisms and risk of oral cancer by Zaini, Z.M., Karen-Ng, L.P., Cheong, S.C., Gurdeep, S.M., Yuen, K.M., Tay, K.K., Jalil, N., Ismail, S.M., Jallaluddin, A., Zain, R.B.

“…Objectives: This study was done to investigate the role of single nucleotide polymorphisms(SNPs) within genes of phase I (CYP1A1) and phase II (GSTM1, GSTT1,GSTP1) of the xenobiotic metabolism and its association with oral cancer risk.Methods: An unmatched case-control study was conducted using 207 newly diagnosed oral cancer patients and 117 non-cancer subjects selected from the OCRCC database. …”
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MDM2 splice variants in Oral Cancer by Sam, K.K., Ng, K.L.P., Ismail, S.M., Zain, R.B., Tay, K.K., Cheong, S.C., Chong, C.E., Lim, P., Teo, S.H.

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PD.185 Oral cancer and precancer researchin Malaysia — the database and tissue resource bank by Zain, R.B., Latifah, R.J.R., Razak, I.A., Ismail, S.M., Samsuddin, A.R., Atiya, S.A., Hashim, B.Y., Jallaludin, A., Nasir, W.M., Cheong, S.C., Bustam, A.Z., Mahadzir, W.M.W., Abraham, M.T., Rahman, Z.A.A., Krishnan, G., Kipli, N.P., Norma, J., Tay, K.K., Yuen, K.M., Mocri Team, Members

“…Introduction: Uncoordinated data collection by different research groups prompted the initiation of Malaysian oral cancer Research Initiative (MOCRI) group. Objectives: To coordinate and standardize data and tissue collection and storage, develop a minimum dataset on risk factors, intervention techniques and quality of life of oral cancer patients. …”
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An oral cancer biobank initiative: a platform for multidisciplinary research in a developing country by Zain, R.B., Athirajan, V., Ghani, W.M.N., Razak, I.A., Raja Latifah, R.J., Ismail, S.M., Sallam, A.A., Bustam, A.Z., Rahman, Z.A.A., Hussien, A., Talib, N., Cheong, S.C., Jallaludin, A.

“…Therefore, the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS) were established to systematically collect large number of samples with comprehensive sociodemographic, clinicopathological, management strategies, quality of life and associated patient follow-up data to facilitate oral cancer research in Malaysia. …”
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Promoting oral cancer awareness and early detection using a mass media approach by Saleh, A., Yang, Y.H., Ghani, W.M.N.W.A., Abdullah, N., Doss, J.G., Navonil, R., Rahman, Z.A.A., Ismail, S.M., Abu Talib, N., Zain, R.B., Cheong, S.C.

“…Background and Aim: Less than 50 of oral cancer cases are diagnosed at early stages of the disease and this is in part due to poor awareness and lack of knowledge on the signs and symptoms of oral cancer. …”
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An oral cancer biobank initiative: a platform for multidisciplinary research in a developing country by Zain, R.B., Athirajan, V., Ghani, W.M.N., Razak, I.A., Latifah, R.J.R., Ismail, S.M., Sallam, A.A., Bustam, A.Z., Rahman, Z.A.A., Hussien, A., Talib, N., Cheong, S.C., Jallaludin, A.

“…Therefore, the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS) were established to systematically collect large number of samples with comprehensive sociodemographic, clinicopathological, management strategies, quality of life and associated patient follow-up data to facilitate oral cancer research in Malaysia. …”
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Establishment and characterization of Asian oral cancer cell lines as in vitro models to study a disease prevalent in Asia. by Zain, R.B., Hamid, S., Lim, K.P., Ismail, S.M., Lau, S.H., Mustafa, W.M.W., Abraham, M.T., Nam, N.A., Teo, S.H., Cheong, S.C.

“…Finally, analysis of the tissues from which these cell lines were derived indicated that the cell lines were genetically representative of the tumours, and, therefore, are useful tools in the understanding of the molecular changes associated with oral cancers. …”
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Establishment and characterization of an oral squamous carcinoma cell line from a patient with no apparent habits associated with oral cancer by Sok, C.C., Hamid, S., Peng, L.K., Ismail, S.M., Zain, R.B.

“…Conclusion: This well characterized cell line will be useful tool in the understanding of the molecular changes associated with oral cancer particularly in cases where no clear aetiological factors are present.…”
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MDM2 SNP309 does not confer an increased risk to oral squamous cell carcinoma but may modulate the age of disease onset by Zain , R.B., Hamid, S., Yang, YH, Peng, K. N. L., Ismail, S.M., Lim, K. P., Wan Mustafa, W. M., Abraham, M. T., Teo, S.H., Cheong, S.C.

“…We have previously shown that overexpression of MDM2 is a common event in oral cancers. In the present study, we determined the association between the MDM2 SNP309 polymorphism and oral cancer in 207 oral cancer patients and 116 normal subjects. …”
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MDM2 SNP309 does not confer an increased risk to oral squamous cell carcinoma but may modulate the age of disease onset by Hamid, S., Yang, Y.H., Peng, K.N.L., Ismail, S.M., Zain, R.B., Lim, K.P., Wan Mustafa, W.M., Abraham, M.T., Teo, S.H., Cheong, S.C.

“…We have previously shown that overexpression of MDM2 is a common event in oral cancers. In the present study, we determined the association between the MDM2 SNP309 polymorphism and oral cancer in 207 oral cancer patients and 116 normal subjects. …”
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CD4(+)CD25(hi)CD127(low) Regulatory T Cells Are Increased in Oral Squamous Cell Carcinoma Patients by Lim, K.P., Chun, N.A.L., Ismail, S.M., Abraham, M.T., Yusoff, M.N., Zain, R.B., Ngeow, Wei Cheong

“…However, the presence of Tregs and inhibitory cytokines in oral cancer patients is still unclear. In this study, the presence of circulating Tregs in 39 oral cancer patients and 24 healthy donors was examined by studying the presence of the CD4+CD25hiCD127low cell population in their peripheral blood mononuclear cells using flow cytometry. …”
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Cyclin d1 amplification in tongue and cheek squamous cell carcinoma by Mahdey, H.M., Ramanathan, A., Ismail, S.M., Abraham, M.T., Jamaluddin, M., Zain, R.B.

“…Sociodemographic data, histopathologic diagnoses, lymph node status and survival data were obtained from the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS)coordinated by the Oral Cancer Research and Coordinating Centre (OCRCC), University of Malaya. …”
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Genome wide profiling of tongue and cheek cancer using high resolution array based CGH by Vincent-Chong, V.K., Rahman, Z.A.A., Zakaria, Z., Tay, K.K., Ismail, S.M., Zain, R.B.

“…In order to understand these behaviors, there is a need to look into the chromosomal alterations and gene pathways that maybe associated with oral cancer at these sites. Therefore, the objective of this study is to determine the differences in chromosomal aberrations and gene pathways involved in tongue and cheek cancer using high resolution array CGH. …”
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Human telomerase reverse transcriptase expression in oral carcinogenesis - a preliminary report by Kumar, S.K.S., Zain, R.B., Ismail, S.M., Cheong, S.C.

“…There seems to be an upregulation of hTERT protein expression during the progression of oral cancer, therefore, this may indicate the feasibility of IHC detection of hTERT protein in oral carcinogenesis as a potential diagnostic or prognostic marker.…”
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Immunohistochemical localization of hTERT protein in oral carcinogenesis by Kumar, S., Ismail, S.M., Zain, R.B., Abraham, M.T., Cheong, S.C.

“…Conclusion: There seems to be an up-regulation of hTERT expression with the progression of oral cancer and therefore indicates the feasibility of IHC detection of hTERT protein as a potential prognostic marker in oral carcinogenesis.…”
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Genome wide analysis of chromosomal alterations in oral squamous cell carcinomas revealed over expression of MGAM and ADAM9 by Vincent-Chong, V.K., Anwar, A., Karen-Ng, L.P., Cheong, S.C., Yang, Y.H., Pradeep, P.J., Rahman, Z.A.A., Ismail, S.M., Zaini, Z.M., Prepageran, N., Kallarakkal, T.G., Ramanathan, A., Mohayadi, N.A.B.M, Rosli, N.S.B.M., Mustafa, W.M.W., Abraham, M.T., Tay, K.K., Zain, R.B.

“…A major drawback in diagnosis and treatment of OSCC is the lack of knowledge relating to how genetic instability in oral cancer genomes affects oral carcinogenesis. Hence, the key aim of this study was to identify copy number alterations (CNAs) that may be cancer associated in OSCC using high-resolution array comparative genomic hybridization (aCGH). …”
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